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Biomedical subjects

S Torp-Pedersen

Publications and source records attributed to S Torp-Pedersen.

At least 73 records · Page 4Linked to original sources

Bladder tumor staging by transurethral ultrasonic scanning.

To determine tumor stage, 115 bladder cancer patients with cystoscopic suspicion of invasion underwent transurethral ultrasonic scanning. Seventeen patients who had received radiotherapy were excluded because it proved impossible to differentiate between tumor and irradiation sequelae. Of the remaining 98 examinations, 4 (4.1%) were inconclusive, 73 tumors (74.5%) were correctly staged, 16 tumors (16.3%) were overstaged and 5 tumors (5.1%) understaged. Transurethral ultrasound is regarded a useful supplement to cytoscopy and biopsy in staging of bladder tumors suspected of invasion.

Biopsy↗

Transrectal prostatic ultrasonography. Equipment, normal findings, benign hyperplasia and cancer.

The principles of transrectal ultrasound scanning of the prostate and current imaging facilities are reviewed. The ultrasonic anatomy of the normal prostate is described and illustrated. Exact volumetric determination of the gland is discussed, and the ultrasonic presentation of benign hyperplasia is surveyed. Ultrasonography is useful in the diagnosis of prostatic cancer and in T-staging the tumours. Ultrasonically guided needle biopsy of the prostate is an important component in cancer diagnosis. An aim for ongoing technical developments should be detection of prostatic cancer before it becomes palpable.

Humans↗

Ultrasonic evaluation of age-related human prostatic growth and development of benign prostatic hyperplasia.

In 175 normal men aged 27-70 (median 40) years, the prostate was ultrasonically scanned by the transrectal route. Ultrasonic signs of adenoma were found in 26%. The earliest age at which signs of benign prostatic hyperplasia appeared was 27 years, and the incidence increased with age. Adenomatous prostates were significantly larger than nonadenomatous, with median volume 28.0 (14.5-62.1) ml versus 23.0 (11.3-39.1) ml (p less than 0.0005). The adenomatous prostates also had a larger median volume of the periurethral gland (4.1 ml vs. 3.0 ml; p less than 0.0005) and a larger peripheral zone (23.3 ml vs. 20.2 ml; p less than 0.005). The total prostatic volume increased statistically significantly with age and the growth rate was calculated to be 0.81 %/year +/- 0.25 (S.E.) corresponding to 0.2 ml/year. The growth rate of the periurethral zone was 1.5 %/year +/- 0.5 (S.E.). Volumetric correlation between periurethral gland and total prostatic volume depended on whether or not adenoma had developed. Prostatic volumes measured in vivo by ultrasound are slightly greater than values obtained at autopsy.

Adult↗

Remodeling of angulated distal forearm fractures in children.

Seventy children treated for distal forearm fractures were clinically and roentgenologically reexamined with a median follow-up time of 3.5 years (range, 1.5-6.0 years). The angulation of the fractures and of the epiphyseal plates was measured at the time of healing and at the follow-up examination. The patients were divided into three age groups of 0-5 years, 6-10 years, and 11-15 years at the time of fracture. In children younger than 11 years of age with residual angulation after distal forearm fractures, the change of orientation of the epiphyseal plate toward normal seemed to account for nearly all the actual correction at the site of fracture, up to 28 degrees. In children older than 11 years of age the capacity of correction of the orientation of the epiphyseal plate was preserved, but its influence upon the correction of distal forearm fractures decreased. This did not prevent correction of possible residual angulation at the fracture site--up to 18 degrees. This may be because, in this age group, appositional bone formation and resorption are the most important remodeling factors. The importance of the orientation of the epiphyseal plate is related to the distance between the fracture site and the epiphyseal plate and by the age of the patient.

Adolescent↗

Electron microscopy of ultrasound-guided fine-needle biopsy specimens.

A prospective 3-year study was undertaken in order to assess the value of electron microscopy (EM) as a supplement to routine light microscopy (LM) in ultrasound-guided fine-needle biopsy of suspected abdominal and retroperitoneal tumours. Eight-six of the 899 ultrasound-guided fine-needle biopsies performed during this period were supplemented with EM using the following indications: metastatic lesions with unknown primary tumour, primary retroperitoneal tumours, tumours with atypical clinical histories and where the primary LM evaluation was unable to determine tumour cell type. Two methods of obtaining material for EM were tested, namely, fine-needle aspiration and fine-needle histological biopsy (Surecut). Both methods yielded suitable material for EM evaluation in approximately 80% of the 76 cases where tumour cells were identified by LM. However, it was technically easier to process material for EM when obtained by fine-needle histological biopsy. The results of the 62 cases where suitable material for EM was obtained were grouped according to the histopathological and clinical value of the diagnosis. In 23 cases (37%) EM was without additional diagnostic value. In 12 cases (19%), EM supplied a more precise histopathological diagnosis, but the diagnostic gain was without clinical significance. In 27 cases (44%) EM was of significant clinical value, as the diagnosis by itself was enough to change the investigative procedure and/or the treatment of the patient.

Abdomen↗

Ultrasonically guided percutaneous inactivation of parathyroid tumours.

Four patients with hyperparathyroidism and one parathyroid tumour detected ultrasonically were treated by ultrasonically guided percutaneous injection of ethanol (96%) into the tumour. Normocalcaemia was achieved for a follow-up of 10 months in one patient and of 3 months in another. One patient had a lowered serum calcium level for a follow-up of 5 months. One patient showed no clinical response to treatment but was subsequently shown to have multiglandular involvement at surgical exploration. Ultrasonically guided percutaneous inactivation of solitary parathyroid tumours as an alternative to surgery is discussed.

Adult↗

Ultrasonic visualisation of the inflamed appendix.

A prospective ultrasonic study of the right lower abdominal quadrant was performed in 46 patients prior to appendicectomy. Ultrasonography revealed an inflamed appendix in 24 out of 29 patients with appendicitis and excluded its presence in 16 out of 17 patients without appendicitis. The ultrasonic pattern of the inflamed appendices appeared as echo-poor/echo-free lesions with lack of movement. In six of seven patients with perforated appendices, ultrasonography revealed free intra-abdominal fluid in addition to bowel disease. The possible value of abdominal ultrasound in patients with suspected acute appendicitis is discussed.

Adolescent↗

Bladder tumour control by abdominal ultrasound and urine cytology.

A blind study comparing abdominal ultrasound and cystoscopy was carried out in 186 patients. 20 bladder tumours sized from 2 to 5 mm were overlooked. Combination with urine cytology increased the diagnostic sensitivity. In order to reduce costs and patient inconvenience in the bladder tumour control population abdominal ultrasound and urine cytology is advocated as an alternative to cystoscopy. This control modality seems safe in patients with "low-risk" bladder tumour disease.

Cystoscopy↗

Transperineal fine needle biopsy of gynecological tumors guided by transrectal ultrasound: a new method.

Six patients had transperineal fine needle biopsy of a pelvic mass performed guided by transrectal ultrasound. Five patients following treatment for gynecological cancer with inconclusive gynecological palpation had a transrectal ultrasound examination performed because abdominal ultrasound did not disclose abnormality. One patient with low back pain had a pelvic mass disclosed with abdominal ultrasound and was referred to transrectal ultrasound for biopsy. In all cases a pelvic lesion was visualized with transrectal ultrasound and transperineal fine needle biopsy was performed. In five cases sufficient material for cytological as well as histological evaluation was obtained showing malignant disease. In one case only necrotic tissue was obtained and subsequent operation disclosed inflammatory changes. It is concluded that transrectal ultrasound combined with transperineal biopsy is a valuable diagnostic tool in the follow-up of patients treated for gynecological cancer.

Adenocarcinoma↗

Ultrasonically guided fine needle aspiration biopsy of renal masses.

A consecutive series of 301 ultrasonically guided fine needle aspiration biopsies of renal masses was reviewed. The retrieval rate was 95 per cent and a correct cytological diagnosis was established in 82 per cent of the cases. There were 14 false positive aspirates, for a predictive value of a malignant aspirate of only 93 per cent. All false positive results were misinterpreted as relatively well differentiated adenocarcinoma. We conclude that renal fine needle aspiration biopsy may add information but the risk of a false positive finding must always be considered.

Biopsy, Needle↗

Prostatic biopsy with the 21 gauge Surecut needle. A preliminary report of a new technique.

The 21 gauge Surecut needle is a fine needle system providing regular tissue cores for histological evaluation. Using the Franzén needle sheath, transrectal biopsies were performed on 13 patients and a tissue core obtained in 12 cases. Ultrasonically guided transperineal biopsies were performed on 14 patients and a tissue core was obtained in 13 cases. It is concluded that the 21 gauge Surecut needle is able to yield histological material for prostatic diagnosis.

Biopsy, Needle↗

Ultrasound diagnosis of carcinoma of the urachus.

In a 48-year-old man with dysuria and microscopic haematuria, pyelography, cystoscopy and bimanual bladder palpation showed no definite abnormality. Because of continued symptoms, ultrasound scanning of the abdomen was done three months later. The examination revealed a tumour in close relation to the top of the bladder. Malignant cells were aspirated at ultrasonically guided puncture, and a urachus tumour was suspected. For early diagnosis of urachus tumours, ultrasound investigation of vague bladder symptoms is required.

Adenocarcinoma, Mucinous↗

Percutaneous balloon catheter nephrostomy guided by ultrasound. Results of a new technique.

A new method for percutaneous nephrostomy is described. The renal pelvis is punctured guided by ultrasound and after dilatation of the tract a 10F silicone balloon catheter is inserted. The procedure was successful in 51 of 52 attempts (98%). The catheters were maintained from two to 150 days. Eight catheters slipped out unintended (16%) 27 to 86 days after the insertion. No serious complications were seen.

Catheterization↗