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Biomedical subjects

S Toth

Publications and source records attributed to S Toth.

At least 37 records · Page 2Linked to original sources

The identification and management of drug-seeking behavior in a medical center.

We describe the development of a quality assurance program that monitors prescription medication misuse in a medical setting. The program focuses on patient activities that influence physician prescribing of abusable medications. Seven defining criteria have been developed to judge the presence of drug seeking by patients. When appropriate, a drug-seeking label is attached to the patient's chart and the hospital computer information system. The warning informs the physician and protects the patient from excessive medications.

Academic Medical Centers↗

The rhythmic properties of the motor system.

The resonance properties of the motor control circuits are basic features of the motor system. From our results, it can be concluded that, when the normally existing suppression mechanism weakens, external stimuli or internal impulses may elicit oscillations in the circuits according to the resonant frequency, and tremor will appear. It seems that the resonant frequency is between 5 and 8 Hz, as demonstrated by rhythmic voluntary movement, rhythmic elicited reflex movement and rhythmic modulated voluntary movement modulated by the stimulation of the central motor system.

Action Potentials↗

Separation of the tumor and brain surface by "water jet" in cases of meningiomas.

In the surgery of meningiomas one of the most delicate problems is the separation of the tumor from the brain surface. The authors generally recommend microsurgery to preserve the brain surface anatomically and functionally. For this purpose we have developed a new surgical technique according to our concepts of tissue care. After excavating the tumor from inside the tumor brain surface was separated by repeated "water jets" into the tumor arachnoideal space. The "water jet" was produced by an ordinary bulb syringe. The front pressure of the jets was 300-1000 mm of water and the side pressure 100-300 mm of water. In the tumor-arachnoideal space the spreading water (phys. NaCl) separates the brain from the tumor with utmost care. We operated on 55 meningiomas of different types with the "water jet" technique. The immediate results were anatomically excellent. Intraoperative and postoperative acute and late edemas appeared only in a few cases. The functions of the nearby brain were generally preserved. The surgery was uneventful when the tumor surface was smooth and the tumor was spherical. When the tumor surface was uneven, one part of the tumor extended under the dura as a thin layer or the tumor was multilobulated with expanded vessels between the lobules, more microseparation was necessary. We compared the results of the "water jet" technique with the results of the "pre-water jet" series. The surgery with the "water jet" technique was much shorter and its results were better than those of microsurgery alone.

Brain↗

Therapist's management of tendon transfers.

Rehabilitation of the tendon transfer patient is a challenge to the hand therapist, given the variety of transfers performed and the level of skill, knowledge, and creativity needed to treat them adequately. Careful preoperative evaluation and treatment increase the prospects for a successful result. The postoperative care of the tendon transfer is a team effort by the surgeon, therapist, and patient; each must have a clear understanding of the goals and precautions of each stage of treatment. Restrictions are initially placed upon the patient's mobility to allow healing; these are then reduced as he activates the transfer and then begins to incorporate the new motion into daily activity. Resistance is added gradually to the patient's tolerance, and care is taken throughout the rehabilitation process not to overwork the muscle in its new function. Tendon transfer is never completely restorative, but often makes a striking difference in the patient's functional abilities. The outcome can be very gratifying for the patient and for those who collaborate in his treatment.

Hand Injuries↗

Prevalence of positive epicutaneous tests among infants, children, and adolescents.

We studied 314 otherwise healthy children younger than 18 years of age with epicutaneous testing, and found that 20% of those tested had at least one positive epicutaneous test result. Neomycin, nickel, and potassium dichromate were the most prevalent allergens detected in our study group. We found that sensitization occurred at less than 5 years of age for all but fragrance allergens. Aluminum chambers and the American Academy of Dermatology Patch Test Kit were found to be safe for use in infants, children, and adolescents.

Adolescent↗

Interaction between feline leukaemia virus subgroups in the pathogenesis of erythroid hypoplasia.

The interaction of feline leukaemia virus (FeLV) of subgroups A and C in the pathogenesis of erythroid hypoplasia in cats was studied. Weanling kittens infected with FeLV-A became permanently viraemic but remained haematologically normal over a period of 36 weeks. Similar kittens inoculated with FeLV-C, which produces erythroid hypoplasia when administered to newborn kittens, neither became viraemic nor developed the disease. However, weanling kittens inoculated with a mixture of FeLV-A and C became viraemic, first with FeLV-A and then additionally with FeLV-C, and the emergence of FeLV-C into the blood coincided with the advent of erythroid hypoplasia. When FeLV-C was inoculated into five older cats which had been viraemic with FeLV-A for several months previously, it appeared in the plasma of three of the cats and erythroid hypoplasia was diagnosed in two of these, 16-20 weeks after infection with FeLV-C. These results show that FeLV-A enhances the growth of FeLV-C in cats and overcomes their age-related resistance to FeLV-C. Also, the appearance of FeLV-C in the plasma of cats viraemic with FeLV-A indicates that erythroid hypoplasia will subsequently occur rapidly. These findings are relevant to the origin of FeLV-C isolates and their occurrence in nature.

Anemia, Aplastic↗

A subcortical approach to swallow pattern therapy.

The neuromuscular facilitation technique was experimentally used with tongue-thrust patients in order to examine the results of application of this technique to such a population. Four boys and seven girls with a mean age of 116 months were referred by orthodontists in the greater Detroit area to Children's Hospital of Michigan. Each had previously been diagnosed as manifesting tongue thrust. Brushing, icing, and pressure were applied in a home training program for 6 months. Serial dental models were made at 0,3,6 and 12 months, the latter being used to detect regression 6 months after termination of the therapy regimen. Results are presented to support the contention that neuromuscular facilitation is a useful technique in swallow pattern therapy. Ancillary findings are presented which support the contention that mouth breathing and thumb and finger-sucking precede the onset of tongue thrust.

Adolescent↗