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S Trauzettel-Klosinski

Publications and source records attributed to S Trauzettel-Klosinski.

23 records · Page 2Linked to original sources
PubMed1986

[Significance of the flicker test for follow-up and prognosis in optic nerve neuritis].

In 105 eyes with florid optic neuritis (ON) the sensation of brightness lessened when the frequency of flickering light was reduced to between 5 and 10 Hz, but remained stable or increased in 239 healthy eyes, 106 eyes after an ON had subsided, and 117 eyes with other diagnoses. This Aulhorn Flicker Test is highly accurate (98%) and specific. It gives pathologic results only for florid ON, and yields normal results again after the inflammation has subsided, even though other visual functions may remain reduced. The Flicker Test therefore makes it possible to distinguish between acute, recidivous, chronic and subsided ON, a distinction which is clinically often ambiguous and cannot be made on the basis of visually evoked potentials. The fact that the Flicker Test reveals pathologic conditions even in abortive cases or when an Uhthoff phenomenon is present is of great diagnostic value. Five representative cases from the group of patients with ON are described in some detail to show how the test can be used to judge the course of the disease, course, to predict its prognosis and to distinguish various patterns of development.

Evoked Potentials, Visual↗
PubMed1980

[The effects of topical steroids in epidemic kerato-conjunctivitis (author's transl)].

Fifty-three patients with proven adenovirus type 8 infection were treated at random, in a prospective study, with either artificial tears or topical steroids over six weeks. Severe cases of nummular keratitis, as well as deep keratitis and slight iritis, were significantly less frequent under steroids. No difference existed with respect to the course of the conjunctivitis and the frequency of a superficial punctate keratitis. Furthermore, the overall frequency of nummular keratitis was equal in both groups, its manifestation merely being somewhat delayed in the steroid group. This may even be disadvantageous, as the natural course of the disease could be prolonged. A significant disadvantage of topical steroids, however, was the high incidence of permanent "dry eye" in the post-infection period. Therefore, as long as no effective antiviral treatment for adenovirus infection is available, steroids should only be administered to relieve symptoms in severe cases for a limited time.

Adenoviridae Infections↗
PubMedDate not supplied

The effect of oral prednisolone on visual evoked potential latencies in acute optic neuritis monitored in a prospective, randomized, controlled study.

The Tübingen study of optic neuritis treatment was started in 1980 to apply new and sensitive tests for monitoring a potential therapeutical steroid effect on the course of acute optic neuritis. Visual evoked potentials were used to assess an effect of oral methylprednisolone in a randomized, controlled trial. Forty-eight patients with acute optic neuritis were treated orally either with methylprednisolone (100 mg per day initially, dosage reduction every 3 days; n = 15) or with thiamine (100 mg per day; n = 33) in the control group, 36 of them in a double-blind procedure. A comparison of the two treatment groups indicated that oral methylprednisolone resulted in a faster improvement in visual evoked potential latency in the initial phase (p = 0.015, 4 weeks after onset), but had no benefit after 12 weeks and 12 months. Follow-up showed different types of courses in the visual evoked potential latencies. The visual evoked potential latencies were correlated to other outcome variables, such as visual evoked potential amplitudes, visual acuity, Aulhorn flicker test and perimetry. We were able to handle nonmeasurable latencies in highly pathologic cases by means of ranks (taking into account censored observations).

Acute Disease↗