[An example to be followed].
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Alcoholic Intoxication↗
Biomedical subjects
S Tufik
Publications and source records attributed to S Tufik.
Modifications on dopaminergic and cholinergic systems induced by the water tank technique: analysis through yawning behavior.
Animals deprived of REM sleep by the water tank technique show an important decrease in frequency of yawning, induced by dopaminergic (apomorphine in low doses) and cholinergic (physostigmine and pilocarpine) agonists, if they are tested immediately after the 96 hr of deprivation. In order to understand the mechanisms underlying the effects of REM sleep deprivation on dopaminergic and cholinergic systems, we decided to test the animals after a recovery period of 24 hr. It was observed that apomorphine-induced yawning was still significantly reduced, whereas pilocarpine-induced yawning had returned to normal. The findings suggest that REM sleep deprivation alters dopaminergic and cholinergic systems in different ways: it seems that the interference on the dopaminergic system is prior and stronger than on the cholinergic system, thus its recovery demands more time.
Animals↗
[Hypnotic effect of homeopathic medication and placebo. Evaluation by double-blind and crossing technics].
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Clinical Trials as Topic↗