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S Uga

Publications and source records attributed to S Uga.

At least 91 records · Page 5Linked to original sources
PubMed1983

Studies on the phenotyping system of hyperlipoproteinemias. Evaluation of a new method by enzymic staining of lipids in serum lipoproteins separated by electrophoresis on agarose.

A new electrophoresis of lipoproteins was examined as a means of defining hyperlipoproteinemia phenotypes. The serum lipoproteins of 119 patients with hyperlipoproteinemia whose serum total cholesterol (TC) concentration was more than 250 mg and/or whose triglyceride (TG) concentration exceeded 180 mg per 100 ml were determined by using a method of electrophoretic separation of lipoproteins on agarose and enzymic staining of each lipid component separately. Based on the lipoprotein-lipid profile with the acid of various parameters for distinction, i.e., Type II A, LDL-C greater than or equal to 180 mg/dl: Type IV, VLDL-TG greater than or equal to 130 mg/dl: type II B, LDL-C greater than or equal to 130 mg/dl, 119 patients were classified into Fredrickson's phenotypes of hyperlipoproteinemia. The percentages of phenotypes with those hyperlipoproteinemias were: type II A, 31.1%; II B, 33.6; IV, 29.4%; and V, 5.9% respectively. But types I and III were not observed in this survey. The characteristics of the lipoprotein profiles of each phenotype were clearly identified, and they were: type II A, high peak LDL-C and decrease of HDL-C fraction; II B, high peak of LDL-C and VLDL-TG; IV, high peak of VLDL-TG; V, prominence of chylomicrons and high VLDL-TG peak. The serial observations of the lipoprotein-lipid profiles were very useful for detecting the progressive changes in lipoproteins which occurred during the course of diseases, particularly in cases of secondary hyperlipoproteinemia. In conclusion, the new lipoprotein-lipid profile based on the agarose electrophoresis-enzymic staining method not only offers great help in classification of hyperlipoproteinemia but has contributed to therapeutic management.

Adolescent↗
PubMed1983

Cataract in gyrate atrophy: clinical and morphologic studies.

The clinical appearance of the cataract in nine phakic patients with gyrate atrophy of the choroid and retina is described. The gross and microscopic examination of three cataractous lenses removed from patients 31 years to 47 years of age is reported. Clinically, the lens opacities appeared primarily along the confluence of the sutures posteriorly, interfering with vision because of their location in the visual axis. Histologically the region of the posterior sutures was filled with liquified and degenerated lens material typical of senile cataractous changes. By the second decade, cataract is a uniform finding in patients with gyrate atrophy and appears to be unique as compared with cataracts associated with other forms of retinal degeneration.

Adult↗
PubMed1983

Morphological study of age-related changes in mouse lens.

Age-related changes in the lenses of ddy strain mice, ranging from 4 to 24 months old, were studied histologically. The early change of aging lens was noted as a slight extension of fiber cells into the posterior capsule in the area behind the nuclear bow around 6 months of age. Those cell extensions formed villous projections reaching up to one half of the total capsule by 18 months of age. Another notable change was a decreasing cell population of the lens epithelium and the appearance of their nuclear inclusions. The latter contained rough endoplasmic reticulum, free ribosomes and filamentous matrix at the early stage and a mass of filamentous material at the later stage. This change was initiated by 12 months of age, and became profound with the increase of age. Moreover, the bow nuclei became markedly displaced posteriorly after 14 months of age. At about 18 months of age, when the pathological changes in both epithelial and bow regions became severe, the superficial cells in the posterior cortex showed swelling and atrophy, which soon led to the lens opacity due to accumulation of cell debris and fluid. These histopathological changes associated with aging appear to correspond to the incipient form of posterior subcapsular cataract which is detectable by clinical examinations.

Aging↗
PubMed1980

Membrane alterations during cataract development in the Nakano mouse lens.

The anterior cortical fiber cells of the 12-day-old Nakano mouse lens revealed an extremely large number of gap junctions, the appearance of which was identical to those of the normal lens. Although the number of gap junctions of the cells in the same area at 29 days was comparable to that seen at 12 days, the size of each junction became smaller with cataract formation. The junctions were almost absent in the anterior cortical cells in 7-month-old Nakano mice. Biochemical analysis revealed that the 26,000 MW polypeptide closely associated with the cell membrane was lower in amount in the membrane preparation of the 29-day Nakano mouse lens than in the 12-day lenses. With the membrane fractions of lenses from 90-day Nakano mice, the absence of a major 26,000 NW polypeptide component correlates with the decrease in gap junction structures. The alternations in the gap junctions and membrane associated polypeptides of the Nakano lens may be linked with the steps leading to cataract development.

Aging↗
PubMed1978

A study on electrocardiographic changes during long-term cardiac pacing.

This report describes the clinical evaluation of chest wall stimulation (CWS) follow-up studies in patients implanted with pacemakers and the value of this method for the observation of intrinsic rhythm. The CWS method was used to periodically check the intrinsic rhythm in 25 long-term pacemaker cases with atrioventricular block. After an average of 26.6 months, an improvement of conduction disturbance was seen in four cases (16 per cent), aggravation was noted in 11 cases (44 per cent), and no change was found in 10 cases (40 per cent). In five patients exhibiting aggravation, no intrinsic rhythm could be detected. Improvement was noted only in atrioventricular and not in intraventricular conduction. Six generators with demand failures were also detected during the course of this study.

Aged↗
PubMed1977

Ultrastructure of iris muscles in diabetes mellitus.

Fine structure of iris muscles from 16 iris specimens in patients with diabetes mellitus were investigated by electron microscopy, and the results were compared with those of 10 specimens of senile cataract eye without diabetes of the corresponding age groups. Significant ultrastructural changes were extensively found at the regions of the dilator, sphincter muscles and of the nerves endings adjacent to them. To cytoplasm of the muscle cells was partly occupied by membraneous structures with concentric lamellar appearance. Cytoplasmic vacuolations were noted in the muscle cells. An increased number of the lipid droplets associated with pigment granules in the cells was found in all diabetic iris specimens. These three kinds of pathological changes (lamellar structure, vacuole, and lipid droplet) increased depending on the duration as well as the control of the disease. Althought these findings were noted both in the sphincter and dilator muscles, the latter seemed to be more severely affected. Degenerative nerve endings containing lamellar membraneous structures were observed in a few moderate cases. Nerve fibers frequently diminished in diabetic patients, especially in severe cases with longer duration together with poorly controlled cases. These findings suggest that diabetes involves the iris muscle cells as well as the nerves, and these changes might be a reason to produce a pupillary abnormality.

Adult↗
PubMed1977

Histopathological study of canine optic nerve retina treated by organophosphate pesticide.

The fine structure of pathological changes was examined in the optic nerve and retina of beagle dogs after oral administration by capsule of the organophosphate pesticide ethylthiometon for 2 years. The optic nerve was invariably affected, and the number of myelinated axons markedly reduced. These were substituted for by delicate processes of astrocytes. Changes in the retina were mild and mainly seen in the peripapillary pigment epithelial cells and in the Müller cells of the peripheral retina. These histopathologic findings indicate that long-term administration of ethylthiometon involved both the optic nerce and selected portions of the retina.

Animals↗