[Macroglobulin proteins in sepsis].
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Humans↗
Biomedical subjects
S V Arkhipova
Publications and source records attributed to S V Arkhipova.
[A complex evaluation of the efficacy of aldecin in treating bronchial asthma patients].
AIM: Study of efficiency of inhalation glucocorticosteroid Aldecine. MATERIALS AND METHODS: A 4-week trial of 30 patients with bronchial asthma. Treatment results were evaluated by clinical symptoms, demand of inhalation sympathomimetics, external respiration, viscosity and elasticity of bronchial secretion, concentrations of hydrocortisone and thyroid hormones. RESULTS: Aldecine produced a good clinical effect, improved external respiration, allowed to reduce doses of inhalation beta-adrenomimetics. No deterioration of either bronchial secretion rheology or inhibition of adrenal and thyroid function was seen. Candidiasis was clinically negligible. CONCLUSION: Aldecine proved highly effective and tolerable in patients with bronchial asthma.
Administration, Inhalation↗
[The effect of salben on the rheological properties of the bronchial secretion].
AIM: Assessment of the effect of a new Russian selective sympathomimetic salben (powder for inhalations) on bronchial secretion viscosity and adhesion. MATERIALS AND METHODS: Salben or placebo (sodium bensoate) were given to 82 and 30 patients (control) with bronchial asthma, respectively. The response was assessed by clinical, laboratory and instrumental findings. RESULTS: A statistically significant (p < 0.05) reduction of the viscosity and adhesion (by 15 and 20%, respectively) was noted in the salben group which also demonstrated improved external respiration. CONCLUSION: Salben induced positive effect on bronchial secretion viscosity and adhesion.
Administration, Inhalation↗
Effect of human alpha2-macroglobulin on proliferative activity of rat tumor cells.
The Walker carcinosarcoma cells were cultured in the medium with low concentration (0.25%) of fetal calf serum, in the presence of native or methylamine-treated (modified) human alpha 2-macroglobulin (alpha 2-MG) in vitro. The proliferative activity (3H-thymidine incorporation) of these cells increased in the presence of one or the other alpha 2-MG preparation. It allows to suppose that the human alpha 2-MG may serve as a growth-stimulating factor of tumour cells.
Animals↗
[Immunoenzyme method of lactoferrin analysis].
The authors propose a highly effective method for isolation of lactoferrin from female colostrum. Lactoferrin is measured by the sandwich enzyme immunoassay. Its concentrations in the serum, urine, amniotic and cerebrospinal fluid in health are measured. The advantages of the method for lactoferrin purification and the practical significance of this protein are discussed.
Colostrum↗
[Complex assessment of inhacort effectiveness in bronchial asthma].
AIM: To investigate efficiency of inhacort in long-term (6 months to 2 years) treatment of bronchial asthma (BA). MATERIALS AND METHODS: 67 inpatients and 65 outpatients with moderate BA were divided into two groups. 96 patients of group 1 had received standard combined treatment without glucocorticosteroids (GCS), 36 patients of group 2 had received GCS. Inpatients were given inhacort in a dose 1000 micrograms/day, outpatients took inhacort in a daily dose 500 micrograms/day. The examination scheme included assessment of external respiration function (ERF), blood hydrocortisone, sputum rheology and diagnosis of candidosis. RESULTS: Inhacort treatment has reduced frequency of asphyxia attacks 2.5-fold 30 and 25% of the patients stopped taking sympathomimetics and GCS, respectively. None of the patients had asphyxia as a status. ERF, sputum viscosity improved, hydrocortisone secretion was unchanged. Only 3.8% of the patients developed oral candidosis. CONCLUSION: Inhacort in a dose 1 mg controls BA. 73% of the patients treated outpatiently had no need in hospitalization.
Administration, Inhalation↗
[Evaluation of the function of the hematoencephalic barrier in victims with craniocerebral trauma in critical state].
Estimates of the relative-entry coefficient, molecular profile of the cerebrospinal fluid and of the molecular blood profile based on the comparison of concentrations of proteins with different physical-and-chemical properties enable an evaluation of the function of the hematoencephalic barrier in victims with craniocerebral trauma in critical state. It was possible to state, with such approach in use, that the regulatory and protective functions of the hematoencephalic barrier were changing differently in favorable and unfavorable trauma outcomes, which must be duly considered in choosing a treatment tactics for the above category of victims.
Blood Proteins↗
[A comparative study of alpha2-macroglobulin and pregnancy-associated alpha2-glycoprotein and protein A as possible analogs].
Pregnancy-dependent protein A, alpha 2-glycoprotein as well as alpha 2-macroglobulin were isolated from retroplacental blood serum by means of affinity chromatography. These proteins proved to be similar in their structure, amino acid and carbohydrate compositions as well as in their properties to bind proteinases and to inhibit the enzymatic activity. The hypothesis on possible integration of these proteins into a group of high molecular inhibitors of proteinases is discussed.
Amino Acids↗