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S V Fernandes

Publications and source records attributed to S V Fernandes.

2 recordsLinked to original sources

Postoperative care in functional endoscopic sinus surgery?

OBJECTIVE: To assess the value of nonintervention after FESS. STUDY DESIGN: Prospective study. METHODS: Fifty-five patients with diagnosed chronic rhinosinusitis who failed adequate medical therapy were subjected to FESS. No postoperative care, apart from nasal douching with hypertonic saline after the tenth postoperative day, was done. No antibiotics or steroids were administered routinely. Because 10 patients were not available for follow-up, only 45 patients were included in the study. RESULTS: Success rate judged by at least 50% subjective improvement of symptoms was 95.5%. However, all patients derived some benefit. The occurrence of postoperative synechiae is discussed. CONCLUSIONS: The usefulness of postoperative care of the FESS cavity needs reappraisal.

Adult↗

[Molecular pathobiology in heart failure].

Heart failure is a pathophysiological state resulting from disturbed cardiac function. It is based on complex molecular processes, many of which are not fully understood. During heart failure adaptive mechanisms, that reinstall altered cardiac function, are activated. The main mechanisms are: a) Alteration of the structure and composition of myocytes by myocardial hypertrophy, reexpression of fetal and neo-natal proteins and the expression of certain proto-oncogenes; b) Activation of the neuroendocrinal system, specifically the sympathetic nervous system, renin-angiotensin-aldosterone system and vasopressin release; c) Activation of autocrine and paracrine systems. However, when these systems are activated beyond a certain limit they contribute to heart failure aggravation. This can also be promoted by alteration of the calcium metabolism inherent in heart failure. The synthesis of the counterregulator atrial natriuretic factor is also increased.

Atrial Natriuretic Factor↗