Cardiac rehabilitation in different geographic areas.
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Biomedical subjects
Publications and source records attributed to S V Guzman.
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Cardiovascular disease mortality in the Philippines was studied from the existing vital statistics for 1963-76. Death rates from rheumatic fever and rheumatic heart disease remained unchanged, those for cerebrovascular diseases decreased, whereas mortality rates of ischaemic heart disease (IHD) and hypertensive disease (HPN) increased enormously both in men and women. This increase in IHD and HPN mortality was seen in all age groups. The age-standardized IHD mortality rate in men rose from 33.3 in 1964 to 78.0 in 1976, and that of women from 15.4 to 34.5. The age-standardized HPN mortality rate in men rose from 21.0 in 1964 to 45.6 in 1976, and that of women from 15.6 to 25.5. The male to female ratios in the age-standardized death rates for IHD, HPN and also for all causes increased during this 12-year period. Age-standardized all causes mortality increased clearly in the male population but decreased in the female population of the Philippines. This excess mortality in males is mostly due to the increased cardiovascular disease death rate. This is a clear example of how chronic non-communicable diseases are becoming major health problems in countries where they previously have not been prevalent. Immediate preventive measures are needed in order to control cardiovascular diseases in these countries where disease rates are rapidly increasing.
The pathogenesis of rheumatic fever has been linked to various immune mechanisms involving streptococcal antibodies and heart tissue antigens. Latent myocarditis due to group B coxsackievirus has also been considered as a possible conditioning factor. The validity of the role of infection with group B coxsackievirus in rheumatic fever was tested by determining the incidence of type-specific neutralizing antibodies in sera of Filipino children. Analysis of the results by means of a normal Z-test showed that the incidence in rheumatic children was not statistically significant in comparison to the incidence in asymptomatic children.
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