Biomedical subjects
S V Hoover
Publications and source records attributed to S V Hoover.
Role of radiation therapy in the management of carcinoma in situ of the larynx.
Twenty-one patients with carcinoma in situ of the larynx were treated with definitive irradiation from 1959 to 1987. The in situ changes were limited to 1 vocal cord in 19 patients, and to both vocal cords in 1 patient. One patient demonstrated extensive in situ changes involving the vocal cords bilaterally, as well as the anterior commissure, with both supraglottic and infraglottic extension. The mean follow-up from completion of treatment was 6.2 years, with a median of 50 months. Definitive irradiation resulted in a local control rate of 95%. The patient with extraglottic spread of in situ changes experienced a local failure 7 months after completion of treatment and, despite surgical salvage, died of local recurrence. This patient represents the only recurrence in our series. Our data suggest that radiation therapy can provide excellent control in carcinoma in situ limited to the true vocal cord.
Results of radiation therapy in early glottic carcinoma: multivariate analysis of prognostic and radiation therapy variables.
A detailed retrospective analysis was performed with 103 patients who had T1 carcinoma of the glottic larynx and underwent radiation therapy between 1960 and 1987. Prognostic and radiation therapy variables were analyzed including sex; age; staging procedures; mucosal extent; histologic grading of tumor; field size; use of wedges; treatment of alternate fields versus both fields every day; nominal standard dose; time, dose, and fraction; dose per fraction; total radiation dose per fraction; total radiation doses; and the impact of cord stripping. Initial local control was 89%, and ultimate control after surgical salvage was 97%, with a 5- and 10-year adjusted survival of 98%. Univariate analysis indicated that larger field size (P = .04), histologic grade (P = .02), and treatment strategy (P = .08) were of some value in predicting recurrence. Multivariate analysis indicated that field size (P = .03) was the only significant variable in predicting local recurrence. These data confirm that radiation is highly effective in the treatment of early laryngeal cancer.
Classical and anaplastic seminoma: difference in survival.
Classical and anaplastic seminoma are traditionally treated with radiation therapy and are said to have the same prognosis. A retrospective study was undertaken of 90 seminoma patients treated with radiation therapy between 1961 and 1985. The classical group consisted of 71 patients of whom 50 had stage I and 21 had stage II disease. The anaplastic group consisted of 19 patients of whom ten had stage I and nine had stage II disease. The median follow-up time was 64 months for the entire group. The 10-year relapse-free survival rate for the classical group was 94% and for the anaplastic group was 70% (P less than .05). For patients with classical stage I disease, the relapse-free actuarial survival rate was 98%; for patients with anaplastic stage I disease, it was 64% (P less than .02). For the classical stage II disease group, the relapse-free actuarial survival rate was 84% and for the anaplastic stage II disease group, 75% (P less than .70). Four patients in the classical group (6%) had relapses; of these, one patient had local recurrence of tumor, and three had distant metastases. In the anaplastic group, four patients (21%) had relapses; two patients had local recurrence of tumor, and two had distant metastases. Therefore the data suggest a difference in survival and relapse rates between classical and anaplastic seminoma.
Optic glioma in children. Review of 16 cases given megavoltage radiation therapy.
From 1967 to 1975, 16 consecutive children with optic-tract glioma were treated with postoperative irradiation. Clinical, surgical and pathologic findings have been summarized. Doses ranged from 4,000 to 6,000 rad. As of 1976, follow-up had been obtained in 13 of 16 children. 9 of 13 survived and 3 were lost to follow-up. We have been unable to relate survival to age, sex, pathologic grade, radiation dose of field size. Although all patients in our series were irradiated, it appears that survival is excellent for those with gliomas that are confined to the optic nerve or chiasm without hydrocephalus even if postoperative irradiation is not given. In patients with extension beyond the chiasm or with hydrocephalus, survival may be improved by the addition of irradiation. A staging system is proposed.
Plasma cell granuloma of the lung, response to radiation therapy: report of a single case.
A benign, inflammatory lung mass was discovered in a healthy 15-year-old boy who had no chest symptoms. A biopsy was performed, but total removal was not attempted. The histologic diagnosis was plasma cell granuloma of the lung. Because of progressive enlargement of the lung mass, radiation therapy was given and the mass has slowly regressed. Although surgery of these lung lesions is the preferred treatment, radiation therapy should be considered if there is no regression or if the mass continues to enlarge.
Radiotherapy for postoperative persistent cancer of the head and neck.
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