PubMed Health⌕ Search

Biomedical subjects

S V Kharchenko

Publications and source records attributed to S V Kharchenko.

At least 19 recordsLinked to original sources
PubMedDate not supplied

[New approaches to the diagnosis of carbohydrate metabolic disorders].

A bioenergetic conception of insulin-independent diabetes mellitus (IIDM) is put forward. Molecular mechanisms of carbohydrate and fat metabolism are discussed which result in a vicious regulatory cycle to provoke a transition to stable pathology. Previously unknown role of human saliva in oral cavity in this regulatory cycle is revealed. New diagnostic tests are developed on the basis of the conception on IIDM pathogenesis. The results of clinical trials are presented which have been obtained during population screening.

Carbohydrate Metabolism↗
PubMedDate not supplied

[Patterns of highly glycosylated proteins from human saliva].

Mucine-like glycoproteins have been studied by structural indication. Textures of these compounds have been described. Possibility for using mucines as matrix structures in microcrystallographic method of analysis of complex multicomponent systems has been discussed.

Chromatography, Agarose↗
PubMedDate not supplied

[Regulation of the RNAse activity of the saliva in healthy subjects and in stomach cancer].

Acidic and alkaline RNase activity from healthy humans and gastric cancer patients has been studied. A decrease in daily saliva production and an increase in RNase activity was detected saliva of cancer patients. This suggests the existence of RNase inhibitors in healthy humans. This supposition is further confirmed by comparative analysis of total, joint fractional and reconstituted RNase activity. A considerable increase in acidic RNase inhibitors and disappearance of alkaline RNase inhibitor was observed in cancer patients. The specificity, mechanisms and clinical significance of this phenomena has been discussed.

Circadian Rhythm↗