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Biomedical subjects

S V Lebedev

Publications and source records attributed to S V Lebedev.

53 records · Page 3Linked to original sources
PubMed1986

[Baroreflex regulation of circulation in essential hypertension patients treated with anaprilin].

The effect of propranolol on the baroreceptor reflex and the main indices of the central hemodynamics in single (i. v.) and prolonged (per os) administration of the drug were studied in patients with essential hypertension. The hemodynamic effect of propranolol depended, to a large extent, on the initial value of the baroreflex and its time course during treatment. Possible mechanisms of the effect of propranolol on the baroreflex were discussed.

Administration, Oral↗
PubMed1981

[Role of age in the dynamics of the syndromologic structure of borderline mental disorders in children (according to data from epidemiologic studies)].

Borderline psychic diseases were studied (on the basis of the results of epidemiological examinations) in 11,000 urban children aged 0 to 14 years. The studies have revealed a relationship between the clinical manifestations of a disease and the age factor. Prevalent psychopathological syndromes, as well as symptoms characteristic for this or that age period were disclosed. A mathematical correlation analysis of the inter-connections between the environmental factors and individual reactivity on the one hand, and the neurotic and neurosis-like disorders on the other showed that the above factors were of no equal importance for children of different age groups. The data obtained are necessary for solving problems concerning the differential diagnosis, prognosis, therapy, and prophylaxis of psychic diseases in children.

Adolescent↗
PubMed1977

[Structures of the morbidity in a group of neuroses and neurosis-like disorders in children and adolescents].

The authors conducted a comparative study of the prevalence and structure of neuroses and neurotic-like nonprocessual disorders in children according to the results of a frontal epidemiological study of 15000 rural and urban population from 0-14 years of age. The obtained data of the prevalence and structure of neurotic and neurotic-like disturbances may serve as a basis for solving some practical problems and particularly for a scientifically grounded programme of mental health services.

Adolescent↗
PubMedDate not supplied

PEGylated immunoliposomes directed against brain astrocytes.

Polyethylene glycol (PEG)ylated (stealth) immunoliposomes directed against human gliofibrillary acidic protein (GFAP) were prepared by coupling the thiolated monoclonal anti-GFAP antibodies with a maleimide derivative of phosphatidyl ethanolamine of the liposomal membrane. Experiments with cell cultures demonstrated specific and competitive binding of these immunoliposomes to embryonic rat brain astrocytes. Administered intravenously into rats, the immunoliposomes displayed typical kinetics with elimination half-lives of 8-15 hr. Being incapable of penetrating the unimpaired blood-brain barrier (BBB), these immunoliposomes, nevertheless, may be useful in delivering drugs to glial brain tumors (which continue to express GFAP) or to other pathological loci in the brain with a partially disintegrated BBB.

Animals↗
PubMedDate not supplied

[Current tasks of hygienic provisions of metro design and construction].

A new part of the existing document on sanitary norms and metro design is proposed to present as a separate section "Hygienic and Ecological Requirements". Its structure should be determined by current views on the regulated environmental factors (physical, chemical, biological, ergonomic). Requirements should be systematized by hygienic criteria of the duration and rate of the human influence of these factors by taking into account of the functional purpose of premises and erections.

Ecology↗
PubMedDate not supplied

[Criteria of efficiency of transplantation of embryonic nervous tissue preparations in rats with 6-OHDA-impaired dopaminergic nigrostriatal system].

Effectiveness of transplantation of cells from embryonal nervous tissue of the ventral mesencephalon (VM ENT) and striatum (STR ENT) by apomorphin-induced motor asymmetry (APO-test), consolidation of the transplant (the degree of glyal reaction and amount of dopaminergic neurons) and blood serum levels of GFAP was studied for 3 months in Wistar rats with 6-OHDA-impaired dopaminergic nigrostriatal system. Marked therapeutic effectiveness was registered in VM ENT transplantation in the denervated striatum and in combined transplantation of VM ENT into the lateral cerebral ventricle simultaneously with STR ENT transplantation in the striatum. Separate transplantation of VM ENT in the lateral ventricle and STR ENT in the striatum had no positive effect on recovery of the dopaminergic nigrostriatal system. A correlation was found between the degree of glial reaction of ENT transplants, severity of rotation asymmetry and serum levels of gliofibrillary protein (GFAP). GFAP in the serum for lifetime assessment of transplant consolidation and prognosis of neurotransplantation efficiency was assayed.

Animals↗
PubMedDate not supplied

[Production and characteristics of PEGylated immunoliposome transport vectors specific for neural tissue astrocytes].

PEGylated (stealth) immunoliposomes covalently linked to antibodies against human gliofibrillary acidic protein (GFAP) were prepared by coupling the thiolated monoclonal anti-GFAP antibodies, D4, with a maleimide derivative of the phosphatidyl ethanolamine of the liposomal membrane. Depending on the initial protein-to-lipid ratios, the immunoliposomes prepared (with a diameter of about 70 nm) were coupled with 60 to 240 molecules of the antibodies. In vitro experiments with cultures of the embryonic rat brain astrocytes demonstrated a specific binding of these immunoliposomes, which could be inhibited by the preincubation of the cells with free non-coupled D4 but not with non-specific antibodies. Administered intravenously into rats, the immunoliposomes exhibited a kinetic behaviour typical for the PEGylated liposomes: after 24 h, approximately 20% of the doses injected were still present in the blood; the elimination rate constants were 0.05-0.09 h(-1), the elimination half-lives were 8-15 h. With such a systemic longevity, as well as with such a specificity, these immunoliposomes, non-penetrating through intact blood-brain barrier (BBB), should be useful in delivering pharmacological agents to glial brain tumours (which continue to express GFAP) or to other pathological loci in the brain with a partially disintegrated BBB.

Animals↗