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S V Magaeva

Publications and source records attributed to S V Magaeva.

10 recordsLinked to original sources
PubMed1991

[Dopamine antibodies in the pathogenesis of parkinsonism].

L-DOPA and dopamine (DA) binding antibodies were found in the blood serum of Parkinsonian patients and middle-aged and elderly normal persons. DA-binding serum gamma-globulins of parkinsonian patients injected into rat caudate nuclei induced the pathogenetic mechanism of Parkinson's syndrome (generator of pathologically enhanced excitation) in these brain part and evoked main parkinsonian symptoms (oligokinesia, rigidity, tremor). The serum gamma-globulins of Parkinsonian patients without Da-antibodies caused less pronounced EEG disturbances. Parkinsonian symptoms developed rarely and were shorter and less pronounced compared with the DA-antibody effect. The DA binding antibodies role in Parkinson's syndrome pathogenesis and is L-DOPA therapeutic tolerance formation was discussed.

Adult↗
PubMed1989

[EEG changes and symptomatic parkinsonism after intracaudate administration of dopamine antibodies].

Intracaudate bilateral injection of the dopamine antibodies caused the formation of the generator of pathologically enhanced excitation in caudate nuclei. All the rats exhibited the oligokinesia, rigidity and head tremor were observed in most animals. These abnormalities could be observed during 24 hours. The possible role of dopamine antibodies in parkinsonism pathogenesis is discussed.

Animals↗
PubMed1988

[Structural bases of the induction of immune reactions in emotional stress].

Immobilization stress in rats can provoke damages of the brain parenchymal vessels, which are most pronounced in the reticular formation of the midbrain. In this case the blood plasma and cells enter the brain and the blood elements of brain tissue enter the circulation. Some experimental animals exhibit the serum complement-fixing brain antibodies and specific reactions of basophils to brain antigens 14 days after exposure to stress. Most of the rats reveal immune reactions and neurosensitivity a month later. Some of them exhibit the autoantibodies to norepinephrine and serotonin. It is suggested that stress-induced brain vascular damages may play an important role in the mechanisms of immune reaction induction.

Animals↗
PubMed1978

[Data on a study of the nature of secondary immunodeficient states. I. An immunophysiological analysis of the mechanisms of allergic reaction suppression in experimental lesion of the structures of the dorsal hippocampus].

Experiments on rabbits demonstrated that local electrocoagulation of the dorsal hyppocampus portions by means of the implanted electrodes caused reduction of the complementary and lysozyme activity of the blood serum, inhibited the development of Arthus' skin allergic-reaction, decreased the intensity of systemic anaphylaxis to the blood serum antigens, this being accompanied by a relative fall of the precipitating antibodies titres and a reduction of the vagus response of the heart to adrenaline.

Animals↗
PubMedDate not supplied

[Detection of latent spontaneous pathology of the central nervous system and visceral organs in rabbits by determining antibodies to tissue antigens and by a test for delayed hypersensitivity].

Complex immunological, pathologicoanatomic and histopathological examination of intact rabbits revealed a correlation between the appearance of complement fixation antibodies and delayed hypersensitivity to tissue antigens on the one hand and the development of spontaneous pathology of the corresponding organs on the other. Meningoencephalitis was diagnosed in all sick animals by means of immunological tests. Tests for antibodies and delayed hypersensitivity to tissue antigens revealed intracapillary glomerulonephritis, coccidiosis of the liver, and pneumonia. The authors recommend conduction of immunological tests for detecting latent spontaneous pathology in laboratory animals.

Animals↗