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S V Nizhniĭ

Publications and source records attributed to S V Nizhniĭ.

18 recordsLinked to original sources
PubMed1985

[Structure-activity relationship in the series of muscarinic acetylcholine receptor agonists: three types of agonist-receptor complexes].

A new procedure has been applied to analyze the data available in literature on the structure-activity relationships for agonists of the muscarinic acetylcholine receptor. The agonists were subdivided into three groups, each containing the compounds with the specific structural element. The binding constant logarithms, characterizing the agonist association with the receptor, increase linearly with the increase in the partition coefficient logarithms describing the distribution in the water-octanol system. The performed analysis suggests the existence of three different types of agonist-receptor complexes.

Animals↗
PubMed1985

[Structure-activity relationship in the series of muscarinic acetylcholine receptor antagonists: four types of antagonist-receptor binding].

The data available in literature on the structure-activity relationships in the series of muscarinic antagonists have been analyzed. Three groups of the ammonium compounds are distinguished, each containing a specific chemical structure element. For the antagonist association with the receptor, the binding constant logarithms within each group depend linearly on the partition coefficient (pi) logarithms characterizing their distribution in the water-octanol system. The linear regression coefficients for pi are practically identical. A separate group consists of antagonists that have no ammonium grouping. Four possible modes of antagonist-receptor binding are surmized.

Animals↗