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Biomedical subjects

S V Pillay

Publications and source records attributed to S V Pillay.

7 recordsLinked to original sources

Right pulmonary artery sarcoma.

A 57-year-old man presented with cough, chest pain and dyspnea. Peripheral lung opacities detected radiologically on admission were surgically resected and histologically confirmed as pulmonary infarcts. Subsequent radiological examinations revealed a stricture of the right pulmonary artery with evidence of pulmonary hypertension. The patient was commenced on anticoagulant therapy, which resulted in some clinical improvement. A hilar mass detected later was resected together with the right lung. Pathological examination of the hilar mass revealed a tumour within the lumen of the pulmonary artery causing almost total occlusion of the artery. Histology showed angiosarcomatous and osteosarcomatous areas. The patient is well and disease-free 9 months following resection.

Disease-Free Survival↗

Coexistent gastric MALT lymphoma and Kaposi sarcoma in an HIV positive patient.

A 47 year old HIV positive male presented with haematemesis and epigastric pain. A gastrectomy was performed for intractable bleeding. The cause of the haematemesis proved to be a Kaposi sarcoma of the stomach which had resulted in mucosal ulceration. Several other smaller foci of Kaposi sarcoma were also present. Coexistent with the Kaposi sarcoma was a dense lymphoid infiltrate with lymphoid follicles and reactive germinal centres. Centrocyte-like cells caused marked effacement and destruction of gastric glands with the formation of lymphoepithelial lesions, typical of a MALT lymphoma. These cells were of B cell lineage and some expressed the HIV antigen, p24. Follicular dendritic cells and macrophages within germinal centres were also p24 positive. Immunohistochemistry and in situ hybridisation did not detect Epstein-Barr virus. Although Helicobacter pylori was not identified by light microscopy in the sections sampled, this does not preclude its possible role, with other cofactors such as HIV, in the causation of the MALT lymphoma.

Gastrectomy↗

Intrapericardial teratoma: A case report.

Successful removal of an intrapericardial teratoma in an adult, with the adjunct of cardiopulmonary bypass, is described. Unusual features are the rarity of the tumour, the recognition of the tumour in adult life (most are recognized during infancy), and the use of cardiopulmonary bypass as a technical aid because of firm adhesion of the tumour to vital structures.

Adult↗

Hyperinfection with Strongyloides stercoralis. A report of 3 cases.

Three patients with chronic diarrhoea, paralytic ileus and malabsorption are reported. At postmortem examination Strongyloides stercoralis was shown to be the aetiological agent in each case. Factors involved in hyperinfection with Strongyloides are discussed and the means of clinical recognition of this syndrome are emphasized.

Adolescent↗