Biotechnology patents in the food sectors.
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Biomedical subjects
Publications and source records attributed to S V Ramani.
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A case of Schilder's cerebral sclerosis presenting as schizophrenia-like psychosis is described. The patient exhibited only minimal neurological signs and the correct diagnosis was established by computerized cranial tomogram (CT-scan).
Bilateral stereotactic fields of Forel surgery was carried out in 6 adults with chronic intractable epilepsy associated with multifocal EEG abnormalities. During an average 40 months follow-up, a significant reduction in the frequency of generalized tonic-clonic seizures was noted in 4 patients. Complex partial seizures in 3 patients and akinetic-myoclonic seizures in 1 did not respond to surgery. Neuropsychological testing revealed a mild to moderate postoperative cognitive decline in 4 patients. Fields of Forel surgery, while partially effective in generalized tonic clonic seizures, appears justified only in patients with such severe preexisting cognitive deficits, that the benefits of seizure control definitely outweight the risk of further cognitive decline.
The coexistence of epileptic and hysterical seizures in the same patient is not rare and creates problems in diagnosis and management. The authors used simultaneous video-EEG monitoring to document the diagnosis of hysterical seizures in 9 epileptic patients; clear-cut hysterical seizures were seen in all 9. The authors used individualized re-educative psychotherapy to teach patients alternative coping techniques and discharged them on minimum dosages of anticonvulsants. None of the patients had a classical hysterical personality, which suggests that conversion reaction is a more appropriate diagnosis, The etiology of "hysterical" seizures varies; the authors emphasize individualized treatment and long-term follow-up.
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Individuals with intractable epilepsy have a murky existence, fraught with medical helplessness, social rejection and personal despair. Drugs control many, but unfortunately not all, cases of epilepsy. An attempt to elucidate on the indications, selections and rationale for the stereotaxic interruption is made. Three cases of intractable epilepsy treated by stereotaxic Fields of Forel Interruptions are reported with special emphasis on pre and postoperative evaluations. Based on the data so far available, it appears that a significant number of patients with medically intractable epilepsy who are not candidates for "standard" neurosurgical interventions, can be helped further by stereotaxic interruptions with minimal morbidity.
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