[Use of ribonucleic acid in the insulin therapy of alloxan diabetes in rabbits].
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Animals↗
Biomedical subjects
S V Varga
Publications and source records attributed to S V Varga.
[Nucleic acid and protein biosynthesis in the androgen-sensitive organs of intact male rats given the nonsteroid antiandrogen niftolide].
In experiments on adult male rats it was found that the oral injection of non-steroid antiandrogen 4-nitro-3-trifluoromethylisobutyranilide (niftolide) in a dose of 25 mg/kg during 8 or 30 days induces atrophy of the accessory genital glands and the levator ani muscle and a decrease in the nucleic acid and protein content. Niftolide "castration" effect is realized through its ability to inhibit biosynthesis of these compounds in androgen-sensitive organs. The antiandrogen dose used exerted a potent prolonged antiandrogenic action, despite its stimulating effect upon the hypothalamic-hypophyseal-gonadal system.
Anal Canal↗
[Estradiol-binding and estradiol-inhibiting capacity of the target organs in female rats with brain-disturbed sexual differentiation].
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Animals↗
[Nucleic acid and protein biosynthesis in the accessory sex organs of rats during blockade of testosterone effect by androgen antagonist 4-nitro-3-trifluoromethylisobutyranilide].
The influence of testosterone and antiandrogen 4-nitro-3-trifluoromethylisobutyranilide (4N3TFMIBA) on the content and biosynthesis of nucleic acids and the protein in the ventral prostate and the seminal vesicles of Wistar rats was studied under experimental conditions. As revealed, with the simultaneous administration of the androgen and its antagonist there was a fall in the organs under study of the RNA and protein content and a reduction of incorporation of labeled precursors into the DNA, RNA, and protein. Similar changes were seen after castration. A conclusion was drawn that the capacity to block the stimulating influence of testosterone on the nucleic acid and protein biosynthesis underlay "castration" effects of antiandrogen 4N3TFMIBA, this causing atrophy of the accessory genital apparatus.
Anilides↗
[Estradiol-binding and estradiol-retaining capacity of target organs of female rats with disorders in the sex differentiation of the brain].
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Animals↗
[Anti-androgenic activity of various substituted carboxyanilides].
The synthesis of 10 substituted carboxy anilides was performed and their antiandrogenic activity was investigated. It was shown, that 4-nitro-3-trifluoro-methyl-alpha-hydroxy-isobutyranilide, 4-nitro-3-trifluoro-methyl-isobutyranilide and 4-nitro-3-trifluoro-methyl-ethyl-methyl acetanilide exert the most pronounced antiandrogenic effects in experimental immature castrated male rats, given substituted doses of testosterone propionate. The antiandrogenic activity is mainly caused by the presence of trifluoro-methyl- and nitro-groups in meta- and para-positions of anilide benzene ring, as well as by hydroxyl group and hydrogen atom presence in alpha-carbon atom of the molecule alkyl moiety. A possible use of non-steroid antiandrogens for studying androgen mechanism of action and treating androgen-dependent diseases is discussed.
Androgen Antagonists↗
[Effect of 131I incorporation on the status of the reproductive system in male rats and the dose-dependent effect].
Radioactive 131I was injected in single doses 9.25, 37, and 92.5 kBq to prepubertal (30-day-old) male rats. Iodine incorporation in doses 37 and 92.5 kBq resulted in some functional changes in the reproductive system of mature rats: blood testosterone level increased, its hypothalamic aromatization intensified, and biologically active LH level in the blood dropped. Incorporation of 9.25 kBq of 131I had no effect on male reproductive system. A possibility of direct injury to rat testicles by 131I incorporation is suggested.
Animals↗
[Evaluation of the gonadoliberin and niftolid tests in the diagnosis of male hypogonadism].
Comparative analysis with an antiandrogen niftolid and synthetic GnRH was carried out in 22 normal subjects, 14 patients with primary and 20 ones with secondary hypogonadism, and in 5 patients with clinical signs of gonadal insufficiency and obscure diagnosis in order to elucidate the pituitary gonadotropin reserves. Blood plasma and daily urine gonadotropin levels were measured. Changed gonadotropin excretion under the effect of niftolid in health and hypogonadism was in line with changed gonadotropin level in the blood after RF administration, this indicating a similar informative value of both tests for the differential diagnosis of various hypogonadism forms. In the first case measurements of blood gonadotropin were more informative, in the second daily urine analysis. Niftolid test, noninvasive and readily available, is recommended as an alternative test with RF administration.
Adolescent↗
[The reproductive function of male rats in the late periods after x-ray irradiation].
Reproductive function in male rats was studied in 1, 3 and 6 months after X-ray irradiation of doses of 2 and 3 Gy. It has been established that long-term effects of irradiation at a dose of 3 Gy are manifested through decrease in spermatozoa content in the epididymis and reduction of nucleic acid and protein content in the testes. Fertility of male rats under study significantly lowered shortly after irradiation and full recovery of fecundating ability was observed 6 months later. The effect of irradiation with a dose of 2 Gy was less pronounced.
Animals↗
[The functional activity of the hypothalamo-hypophyseal-gonadal system in male rats in the late periods after x-ray irradiation].
The hypothalamo-hypophysis-gonad system was studied in male rats 1, 3 and 6 months after external irradiation with doses of 2 and 3 Gy. Irradiation with a dose of 3 Gy was shown to cause a decrease in the level of LH and testosterone in blood plasma, impairment of steroidogenesis in the testes and diminution of their mass. All this was most pronounced 6 months after X irradiation. The morphofunctional status of prostate, inhibited by X radiation, was restored by that time.
3-Hydroxysteroid Dehydrogenases↗
[Recovery of various parameters of the functional state of the reproductive system in thymectomized rats as affected by thymic membrane factor].
Ten-month-old male rats thymectomized in early post-puberty were ascertained to have lower plasma luteinizing and testicular hormones and higher testicular steroid dehydrogenase activity. Following 24 hours of administration of a thymocyte membrane structural agent, pituitary gonadotropic and gonadal androgenic functions became normal. There was no agreement between the hormonal parameters and the levels of nucleic acids in the testes and prostate.
Animals↗
[The correlation of the hormonal and clinical effects in patients with prostatic cancer undergoing niftolid treatment in combination with low doses of synestrol].
Effects were studied of niftolide in tablets, 0.25 g on a three-times daily basis in combination with low doses of sinestrol, 5 mg intramuscularly within 24 h, on tumor growth, blood plasma content of luteinizing hormone (LH), testosterone (T) and testosterone-estradiol-binding globulin (TEBG) in 46 patients with prostate gland carcinoma, including seven patients with metastases. After treatment for three months, plasma T level decreased by 63%, that of LH by 53% whereas TEBG increased twice as much. The treatments were administered for as long as 10 months, with estrogen therapy being tapered to a dose of 3 mg daily. The above treatment schedule resulted in stabilization or partial regression of tumor growth in as many as 94.9% cases; also deserving to be noticed was improvement in the outflow of urine and alleviation of the pain syndrome. The clinical effect is believed to be due to pharmacological blockade of androgenic receptors in the tumor and its metastases as well as to antigonadotropic activity of estrogen and striking lowering of blood plasma free T.
Aged↗
[Experimental anti-androgenic activity of 4-nitro-3-trifluoromethylisobutyranilide (niftholide) in rats and guinea pigs].
In experiments on rats and guinea pigs is shown the capability of the synthetized nesteroid antiandrogen--4-nitro-3-trifluormethylisobutyranilide (niftholide) to block the stimulating effect of exogenous and endogenous testosteon on the prostate, seminal vesicles and levator ani muscle. The results of histological and morphometric investigations bear proof to inhibition of the hypertrophic reaction of theprostatic epithelium in response to introduction of the androgen. It is inferred that antiandrogenic effect of niftholide with respect to testerone manifests itself on the level of the target-organs.
Anilides↗
[Radioimmunological and biochemical study of the reaction of the adenohypophysis, testes and adrenals in rats and guinea pigs to the administration of the antiandrogen, 4-nitro-3-trifluoromethylisobutyranilide].
A study was made of the influence of antiandrogen 4'-nitro-3'-trifluorome-thylisobutyranilide (niftolide) on the content of the luteinizing hormone, testosterone and corticosterone in the rat blood plasma, the content of testosterone in the blood plasma and on the 17-OCS and 17-KS urinary excretion in guinea pigs. The data obtained pointed to a marked intensification of lutropin and testosterone secretion. The observed changes are explained by the capacity of niftolide to block the inhibitory influence of the androgens of the feed-back mechanism of the gonadotropin secretion control. It is suggested that niftolide can be used for the investigation of the functional condition of the hypothalamo-hypophysio-testicular system. Niftolide had no effect on the indices of the glucocorticoid activity of the adrenal glands in rats and guinea pigs.
17-Hydroxycorticosteroids↗