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Biomedical subjects

S V Vasil'ev

Publications and source records attributed to S V Vasil'ev.

At least 19 recordsLinked to original sources
PubMed2004

[Open hemorrhoidectomy with using the apparatus controlled bipolar electrocoagulation].

Hemorrhoids are known to be a widely spread disease. The aim of this study was to compare two methods of hemorrhoidectomy. The hemorrhoidectomy was performed on 262 patients with combined III-IV degree hemorrhoids, 130 patients being operated by the conventional method--Milligan-Morgan hemorrhoidectomy, 132 patients undergoing hemorrhoidectomy using a bipolar vessel sealing system. It was noted that the operation time was significantly shorter, postoperative pain and postoperative complications less frequent due to the bipolar device-controlled electrocoagulation.

Adult↗
PubMed2003

[Survival of patients with distant metastases of colon cancer after different extent of surgery].

The results of a retrospective non-randomized pair-controlled investigation are discussed. The data on a patient of cytoreductive surgery and another one operated on for symptoms only (control) were compared. Both subjects had to have comparable most important prognostic characteristics, such as gender, age, primary tumor localization and the number and pattern of distant metastases. The study included 34 patients. The surgery group comprised 19 patients (female--13, male--6). Total cytoreductive surgery (5) used standard removal of primary tumor and marginal resection of a segment of the liver (4), or excision of the right lobe (1). Partial surgery (14) involved removal of primary tumor alone. Controls (female--10, male--5) were operated on for symptoms (proctotoreusis--12, shunt--3). No systemic antitumor therapy was given. Concomitant pathology, its absence as well as postoperative complications were excluded from consideration. Median survival in control was 5.2 mo, total or partial surgery--13.5 mo (p = 0.00083). In a longer perspective, it was 27.0 mo for total surgery and 12.6 mo--partial (p = 0.00295), while after partial surgery it was longer than for symptomatic treatment--5.2 mo (p = 0.0029). No correlation was established between survival, on the one hand, and gender, age or primary tumor localization, on the other (p(0.005). However, a relationship was found between survival and extent of excision (p = 0.01737).

Adult↗
PubMed2003

[The scientific and clinical value of molecular genetic changes in the intercellular gap junctions observed in colon cancer].

Colon cancer is one of the most widespread pathologies with high mortality due to recurrence and metastasis. The molecular methods of diagnosis, prognostication and biotherapy in colorectal cancer enjoyed a rapid progress during the recent decades. The hypothesis on the key role of impaired intercellular gap junctions in the onset and progression of malignant tumors is a promising trend in carcinogenesis research. We have recently discovered a variety of tumor-specific mutations of connexin 43 gene in advanced colorectal cancer (Oncogene. -2002.-Vol.21, No.32-pp.4992-4996), which confirms the above hypothesis in malignant tumor progression. We believe that further studies of connexins' mutation changes in tumor growth is a promising trend in research of its etiology and pathogenesis and in designing new methods of diagnostics and treatment of colonic and other gastrointestinal cancers.

Adenocarcinoma↗
PubMed2003

[Comparative assessment of the results of open carotid endarterectomy and carotid aftery stenting].

A comparative study of 48 carotid stent grafting and 23 open carotid endarterectomies was carried out. Patients of both groups were comparable by cerebrovascular insufficiency degree and concomitant diseases. General rate of complications after carotid stent grafting (CSG) was 5.1%. There was a small ischemic stroke with right-sided hemiparesis and aphasia in one patient during CSG. Complete regress of the neurological symptoms was seen on the 5th day. In the nearest postoperative period after CSG there was a big ischemic stroke in the territory of MCA in one patient. Rate of complications after open carotid endarterectomy (OCEAE) was 8.7% Transient ischemic attacks were seen in 2 patients in early postoperative period. Paresis of the IX cranial nerves was in one patient. In long-term postoperative period after CSG 2 patients died due to cardiac causes. One patient died 18 months after OCEAE due to ischemic stroke. In long-term period after OCEAE restenosis of the internal carotid artery was seen in 4.5% cases, while there were no restenosis after CSG. It is concluded that CSG is an effective method of treatment of carotid stenosis with lower lethality and postoperative complications rate compared with OCEAE. Indications for CSG are symptomatic stenosis of ICA (>60%), asymptomatic stenosis of ICA(>70%), two-sided lesions of the carotid arteries, carotid stenosis with lesions of other brachiocephalic arteries, insufficiency of Willis circle.

Adult↗
PubMed2002

[Formation of a colonic reservoir while performing a low anterior resection of the rectum].

The aim of the investigation was to determine the most functionally grounded level of the formation of colonic reservoir from the margin of the anal canal while performing a low anterior resection of the rectum. Sphincter-preserving operations were performed in 113 patient with the formation of colonic reservoir and direct stepler colorectal anastomosis. Questionnaires and apparatus "Colodynamic-3" were used to follow-up 28 patients with the reservoir (main group) and 19 patients with a direct anastomosis on whom the operations had been made more than a year ago. The rate of the development of complications was almost the same in the both groups--28.5% and 26% correspondingly. The reservoir-accumulating function became less in the group of "direct" anastomoses. The best parameters of the reservoir-accumulating and evacuatory ability of the colonic reservoir were found to be in patients with the level of anastomoses 4-6 cm from the anal canal margin. Creation of the reservoir was more difficult in patients with the carneus mesentery and a small width of the sigmoid colon.

Adult↗
PubMed2001

[Mycotic aneurysms of the thoraco-abdominal part of the aorta].

Mycotoc aneurysms (MA)--a rare and extremely dangerous lesion of the aorta. CT, MRA and aortography were used to diagnose MA of the thoracoabdominal areas in 2 men of 64 and 67 years of age. The clinical picture included: fever with shivering with the temperature 38-39 degrees C and increasing pains in the inferiothoracic and lumbar areas of the spine. Hemoculture was positive in 1 patient only. The patients were operated on. Shunting of the aorta from the inferiothoracic to infrarenal segments was performed in one patient with the exclusion of the involved portion and resection of MA. Metalloosteosynthesis of the spine due to destruction of LI-LII and compression of the spine were performed in the second patient followed by analogous shunting of the aorta and visceral arteries with the resection of the aneurysm. To prevent infection of the prostheses the shunts were wrapped up with a piece of the greater omentum. One patient died two months later from recurrent sepsis. The other one is alive, within 28 months the shunts are patent, there are no signs of a reinfection.

Aged↗
PubMed1998

[Damage to the transforming growth factor TGF-beta type II receptor gene and microsatellite instability in carcinoma cells of the gastrointestinal tract].

In order to compare the frequency of damage to the transforming growth factor TGF-beta receptor type II gene (RII gene) and microsatellite instability (MIN) in oncogenesis of sporadic and hereditary cancer of gastrointestinal tract (GIT), 4 groups of carcinomas were analyzed. They included sporadic gastric (GC), family gastric (FGC), sporadic colorectal (CC) and hereditary nonpolyposis colorectal (HNPCC) carcinomas having appropriate clinical and pathological characteristics. Each group consisted of two types of carcinomas, one of them showing MIN. The RII gene damage occurred in 89% of GC (8 cases out of 9), 86% of CC (6 out of 7), 71% of FGC (5 out of 7), 50% of HNPCC (3 out of 6) for carcinomas coupled with MIN, whereas only in 6% (1 out of 18) of GC and 5% (1 out of 22) of CC for carcinomas without MIN. No damage to RII gene was found in the cases of hereditary carcinomas which did not show MIN though the number of cases analyzed was not sufficient for final conclusions (3 cases of FGC and 3 HNPCC). The data revealed a correlation between the MIN phenotype and mutations in RII gene both for sporadic (p < 0.001) and for hereditary (p < 0.02) cases. For all 4 groups the frequency of RII gene damage was found for early and advanced carcinomas. This suggests that the deficiency of TGF-beta receptor complex in both sporadic and hereditary carcinomas of GIT is revealed at early stages of tumor development and consequently may be responsible for tumor progression. The correlation between RII gene damages and MIN in GIT carcinoma cells suggests that genetic change predetermined the neoplasia of colorectal and gastric epithelium and partially overlapped for both sporadic and hereditary cases.

Colorectal Neoplasms↗
PubMed1998

[Microsatellite instability of genome in cells of sporadic and hereditary carcinoma of the gastrointestinal tract].

Microsatellite instability (MIN) of human genome, i.e. instability of very short (1-5 nt) DNA tandem repeats, points to a deficiency in the mismatch repair system (MMR). To investigate the role of MMR in sporadic and hereditary carcinogenesis in the gastrointestinal tract, four types of carcinomas were compared: sporadic (GC), familial (FGC) gastric carcinoma, sporadic colorectal (CC) and hereditary nonpolyposis colorectal (HNPCC) carcinoma. No significant difference in MIN frequency was found between GC (9 out of 27) (33%) and CC (7 out of 29) (24%). In hereditary carcinoma group, MIN occurrence appeared 2-3 times as high: FGC in 7 out of 10 (70%) and HNPCC in 6 out of 8 patients (75%). No significant differences were recorded in MIN occurrence at early and later stages of the disease in all groups. Therefore, it can be suggested that disorders in the MMR develop at earlier stages of carcinogenesis and may be responsible for tumor progression.

Base Sequence↗
PubMed1992

[The use of extraperitoneal colorectal anastomoses in complicated cancer of the rectum and sigmoid].

The paper deals with the issue of primary restoration of intestinal continuity in complicated colorectal cancer using extraperitoneal colorectal anastomoses. The study is based on the experience of treatment of 35 cases of complicated colorectal cancer. It was concluded that, to assure primary restoration of intestinal continuity, the risk of surgery must be weighed with respect to extent of disease, and adequate anesthesiologic and postoperative intensive care is required. The procedure should be performed at a specialized surgical institution.

Aged↗
PubMed1992

[An ethological approach in the study of nonverbal communication in man and chimpanzee].

The nonverbal communication of man and chimpanzee has been studied. Sexual dimorphism of nonverbal communication patterns, which is connected with the definite contexts of behavior are revealed. Possible ways of evolution in communication systems i shown. This analysis will permit to apply the data of ethological investigation of nonverbal behavior as sexual marker in diagnosis of different groups of mentally ill patients.

Animal Communication↗
PubMed1992

[The possibilities for the primary recovery of intestinal continuity in complicated cancer of the left half of the colon].

In 80 patients with complicated clinical course of carcinoma of the left half of the colon the primary restoration of the intestinal continuity was fulfilled (in 47 patients left-side hemicolectomy, in 15 patients subtotal colectomy, in 15 patients-Hartman operations). Postoperative complications were observed in 18 patients (22.5%), 7 patients died (8.8%). Functional long-term results were favorable in most patients. The clinical experience obtained suggests that primary restoration of the intestinal continuity deserves special attention in a number of cases.

Adult↗
PubMed1991

[Lymphocytapheresis and lymphosorption as the methods of pathogenetic therapy of nonspecific ulcerative colitis].

The article presents an analysis of results of treatment of 41 patients with different forms of nonspecific ulcer colitis, in 18 of them drainage of thoracic lymphatic duct was used with the following lymphocytapheresis with the help of a home blood fractionator RK-0.5, SKN activated charcoal sorbents and carbohydrate fiber absorbent, lymphosorption and lymph reinfusion. The method of treatment is highly effective for critical and mild forms of ulcer colitis in patients with total and subtotal injury of the large intestine. The results were followed up during 12-30 months and demonstrated stable remission of the disease.

Adolescent↗
PubMed1991

[Current possibilities of the treatment of severe forms of nonspecific ulcerative colitis].

Treatment of patients with a severe form of nonspecific ulcer colitis with subtotal alteration of the colon is described. The disease was complicated by intestinal bleeding which could not be arrested by conservative therapy, so the Hartman operation was performed. Not traditional methods of treatment of ulcer colitis were used such as drainage of the thoracic lymph duct, lymphocytapheresis, lymphosorption, plasmapheresis which allowed to stabilize the patient's state and to perform radical proctectomy, subtotal colectomy with blind gut descended to the anal canal.

Acute Disease↗