Biomedical subjects

S Varga

Publications and source records attributed to S Varga.

At least 73 records · Page 4Linked to original sources

PubMed1975

Effect of triiodothyronine treatment, thyroparathyroidectomy and mercaptoiminazole treatment on enchondral bone growth. Changes in the histological structure of the growth organ.

Histological changes caused by triiodothyronine (T3) and mercaptoiminazole treatment as well as by thyroidectomy have been studied in the proximal growth organ of the tibia of growing rats. On triiodothyronine treatment morphometric examinations revealed an increased proliferation and resorption of cartilage associated with a transitory acceleration of linear bone growth. Administration of mercaptoiminazole and thyroidectomy inhibited cartilage proliferation and resorption resulting in a slowing down of bone growth.

Animals↗

PubMed1975

The effect of glucose-1 phosphate calcium on the epiphyseal cartilage of the rat.

Electron microscopic investigations were carried out on the proximal tibial epiphyseal cartilage of albino rats treated with 2 mg G-1-P-Ca daily for one and three weeks. The treatment--enhanced the secretory activity of the upper cells of the zone of maturing cartilage with a consequential enlargement of the Golgi region, depletion of secretory products, and an increase in the number of microtubuli. --In addition, the treatment increased the number of matrix vesicles in the extracellular space showing incipient calcification. This findings confirm the earlier light micriscopic observation of the calcification stimulating effect of G-1-P-Ca.

Animals↗

PubMed1975

Examination of sterilization parameters with a view to improving the quality of infusion solutions.

A determining time factor in the course of sterilization in autoclaves is the time required for killing microorganisms. Damaging of microorganisms takes its course as an exponential function of time. Taking into account this fact, the parameters of sterilization are determined by the technical standards of the equipment used for autoclaving. The authors present the sterilization problems of infusion solutions, with special regard to the sterilization conditions of heat labile preparations. The results of experiments carried out with autoclaves of different technical standards are discussed.

Infusions, Parenteral↗

PubMed1975

Effect of triiodothyronine (T3) thyroparathyroidectomy and mercaptoimidazole treatment on enchondral bone growth. II. Growth dynamics in the proximal growth organ of the tibia in young rats.

The 24 hour growth rate of the tibial proximal growth organ was investigated in triiodothyronine or mercaptoimidazole-treated, and in thyroidectomized male rats. Longitudinal growth of the tibia of the same period was also studied. After one week treatment, the 24 hour rate of growth in the triiodothyronine-treated rats was retarded as compared with the controls, whereas at the end of the 3rd and 5th weeks the growth rate of the treated animals exceeded that of the controls. The tibia was somewhat longer in the treated rats than in the untreated controls, though the difference was not significant. The growth rate in the growth organ of mercaptoimidazole-treated and thyroidectomized animals was generally higher than that measured in the controls. The length of the tibia was less than in the controls, but the difference was not significant. The phenomenon is attributed to the altered hormonal conditions.

Animals↗

PubMed1974