Biomedical subjects

S Varsano

Publications and source records attributed to S Varsano.

22 records · Page 2Linked to original sources

PubMed1984

Kaposi's sarcoma and angioimmunoblastic lymphadenopathy.

Kaposi's sarcoma (KS) and angioimmunoblastic lymphadenopathy (AILD) are exceptionally rare neoplastic diseases, although the former has recently been more frequently reported among certain populations, and is lately a topic for extensive medical and investigational interest. This case is unique in that it describes an association between KS and AILD. Such an association raises the question of a common pathogenic mechanism. The authors believe that predisposition to each of both diseases may be related to acquired immune deficiency which in turn may be induced by specific viral infections.

Aged↗

PubMed1983

Hypophosphatemia as a reversible cause of refractory ventilatory failure.

An 81-yr-old male with pulmonary emphysema was hospitalized because of malnutrition and hypoglycemia. This patient developed ventilatory failure requiring mechanical assistance 12 h after initiation of iv hyperalimentation. Severe hypophosphatemia (0.1 mg/dl), mild hypocalcemia, hypomagnesemia, and hypokalemia were subsequently and concomitantly documented. Repeated attempts to wean him from the respirator failed until hypophosphatemia was corrected. When difficulties are encountered in weaning patients from mechanical ventilation, attention should be directed toward detection of hypophosphatemia. This may be crucial in the presence of chronic lung disease.

Aged↗

PubMed1982

Correlation of T-wave changes occurring during exercise ECG with the hemodynamic changes that govern myocardial O2 balance.

Over 200 healthy males 16 to 60 yr of age were examined with the submaximal exercise test (SMET). ECG, heart rate and blood pressure were measured during rest, immediately after exercise and after 5 min of recovery. Relationships were examined between the percentage change of T-wave amplitude (delta T%) on transition from one phase of the test to the other and the percentage changes of five hemodynamic indices which are known to determine myocardial O2 balance. These indices were heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), myocardial tension index (MTI) and cardiovascular effort index (CVEI). Two new indices of myocardial O2 balance, namely, coronary perfusion index (Formula: see text) and demand supply index (Formula: see text) are also presented. All of these correlations were examined in the group as a whole and in various subgroups, according to age an physical fitness. In the highly fit group, there was a negative correlation between delta T% and delta HR% (P less than 0.001), delta MTI% (P less than 0.007) and delta DSI% (P less than 0.003), and a positive correlation between delta T% and delta CPI% (P less than 0.004). In the young, highly fit subgroup, there was a negative correlation between delta T% and delta HR% (P less than 0.001), delta MTI% (P less than 0.01), delta CVEI% (P less than 0.05) and delta DSI% (P less than 0.004), and a positive correlation between delta T% and delta CPI% (P less than 0.01). These correlations were mainly found during the transition from rest to effort. The results indicate that during the SMET, T-wave depression might be a manifestation of negative O2 balance in the subendocardial layer, even in subjects who most probably do not suffer from organic coronary disease.

Adolescent↗

PubMed1980

Minimal-change nephropathy and malignant thymoma.

A 56-year-old man had fever, precordial pain, and a mediastinal mass. The mass disappeared two months later and the patient remained asymptomatic for 2 1/2 years. At that time a full-blown nephrotic syndrome developed, with minimal-change glomerulopathy. The chest x-ray film showed the reappearance of a giant mediastinal mass. On biopsy of the mass, malignant thymoma was diagnosed. Association between minimal-change disease and Hodgkin's disease is well known, while the association with malignant thymoma has not been previously reported. The relationship between malignant thymoma and minimal-change disease is discussed, and a possible pathogenic mechanism involving cell-mediated immunity is proposed.

Humans↗