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Biomedical subjects

S Vesterhauge

Publications and source records attributed to S Vesterhauge.

9 recordsLinked to original sources
PubMed1979

Oral decongestant in acute otitis media. Results of a double-blind trial.

In order to investigate the influence of an orally administered decongestant, norephedrine, upon the clinical course of acute otitis media and tubal function, a double-blind trial was performed in Copenhagen in December, 1976-February, 1977, in which 93 patients, aged 6 months to 10 years, with 135 ears with acute otitis media, were treated either with norephedrine or placebo in a randomized order. Most other treatment was avoided except for pain-relieving baby aspirins. The effect of norephedrine seemed to be no other than that of placebo. Because of this inefficacy of norephedrine the authors have, therefore, a material of patients with acute otitis media where the main treatment was pain-relieving aspirin. The use and abuse of antibiotics in the treatment of this disease are discussed, and the authors stress the necessity of performing controlled studies of the efficacy of antibiotics in acute otitis media, since such studies do not exist.

Acute Disease↗
PubMed1979

A critical evaluation of the glycerol test in Meniere's disease.

From the literature it is apparent that the glycerol test is being used frequently to evaluate Meniere patients, with regard to the choice of treatment, and in particular to find those who are suitable for surgery with different decompressive procedures. In our previous investigations on such patients we found that they often are extremely good placebo responders and it was natural to evaluate how important such psychological factors would be for the outcome of the glycerol test. In a group of patients with typical objective and subjective symptoms of Meniere's disease, the glycerol test was applied twice to each patient. In one of the tests, the patient was told that we would expect hearing to improve. In the other test, where the actual amount of glycerol was the same, we had the solution prepared with a different taste, and the patient was informed that we now would expect the hearing to deteriorate. The sequence of the two tests was randomly chosen for each patient. Most frequently the patient would follow our instructions, i.e. obtained a poorer hearing threshold when instructed to, and vice versa. The results are discussed with a special view to the risk of selection of suggestion-sensitive patients by this test.

Adult↗
PubMed1979

The effects of some drugs on the caloric induced nystagmus.

A striking difference between the two anticholinergic drugs was observed. Atropine only modified the eye speed of the slow phase (mes), whereas scopolamine modified both parameters measured, mes and duration. Amphetamine and caffeine prolonged the duration, leaving the mes unchanged. All antiemetic drugs inhibited both parameters. It is concluded that the effect of a drug on the caloric reaction gives insufficient information in the preclinical evaluation of vestibulo-suppressive drugs.

Amphetamine↗
PubMed1979

A critical evaluation of the glycerol test in Ménière's disease.

The glycerol test is currently widely used to evaluate Menière's disease, particularly in regard to its suitability for decompressive surgical therapy. Our previous findings have shown that patients with Menière's syndrome respond extremely well to placebo treatment. We have investigated the effect of psychological factors in the outcome of the glycerol test. It was administered twice to each of a group of patients with a typical Menière's syndrome. On one occasion the patient was told the hearing would improve, and on the other that the hearing would worsen. The same dose of glycerol was provided for each test, but with a different flavor. The sequence of test was randomly applied. The audiologist was unaware of instructions given to the patient. The patients usually responded as instructed. These results are discussed with particular regard to the risk of patient selection for surgery.

Adult↗
PubMed1978

Aerosol distribution in the nose.

Using a cast of the human nose the intranasal distribution of drugs, delivered from pressurized aerosols and nebulizers was studied. The results indicate that a pressurized aerosol should be used twice in each nostril to give an acceptable drug distribution, and also that an automized pump is preferable for a plastic-bottle nebulizer with regard to drug distribution.

Administration, Intranasal↗
PubMedDate not supplied

Normal values in a routine ENG test.

A total of 50 normal subjects were examined by electronystagmography for spontaneous and positional nystagmus. In this way the normal limit of the speed of the slow phase was determined to be 6.5 degrees/sec. By examining 15 of the subjects twice, the normal limit of the mean value of the two results was determined to be 4.5 degrees/sec. Forty-nine of the subjects were calorically tested, using 30 degrees and 44 degrees C stimulation. The results were calculated as indices expressing the degree of unilateral hypofunction and directional preponderance relative to the total caloric excitability. The results were evaluated for the duration of and for the maximum eye speed of the slow phase. The normal limits were determined as the mean value +/- twice the standard deviation. Our results indicate that a left-side hypofunction is a normal phenomenon and that duration and maximum eye speed of the slow phase reflect different aspects of the vestibular function.

Adolescent↗
PubMedDate not supplied

Oral norephedrine in the treatment of acute otitis media. Results of a double-blind, placebo-controlled trial.

One hundred patients with acute otitis media were treated with oral norephedrine or with placebo for one to two weeks. Symptom cards, otoscopy and tympanometry were used for evaluation of the results. There were no differences between the two groups with regard to acute symptoms or healing of the disease. It is concluded that oral decongestants are of no value in the management of acute otitis media.

Acoustic Impedance Tests↗