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Biomedical subjects

S Vinther

Publications and source records attributed to S Vinther.

13 recordsLinked to original sources
PubMed1991

Vitamin K to neonates. Peroral versus intramuscular administration.

In a randomized study of 300 infants, the effect of 1 mg of peroral vitamin K given at birth was compared to the same dose given as an intramuscular injection. The combined activity of coagulation factor II + VII + X taken after 48 and before 72 hours after delivery served as the primary endpoint. Prothrombin (antigen) and PIVKA II (acarboxyprothrombin) were also measured. All infants were observed for events of bleeding until discharge from the hospital, normally on the fifth day. No significant differences between the groups in any of the biochemical markers were observed. The 95% confidence limits of the differences were very narrow for all factors. No cases of bleeding were observed. We conclude that administration of 1 mg peroral vitamin K is as efficient as intramuscular administration of the same dose in the prevention of classical hemorrhagic disease of the newborn.

Administration, Oral↗
PubMed1988

Random blood glucose sampling as an early antenatal screening test for diabetes mellitus.

Random blood glucose was measured on 1,992 pregnant women during the initial attendance at our antenatal clinic. The visit usually took place during the first part of the second trimester. Women with a random blood glucose concentration in excess of 6.1 mmol/l within 2 hours of the last meal and 5.6 mmol/l more than 2 hours after the last meal were referred for a fasting blood glucose measurement. A 75 g oral glucose tolerance test was performed in those cases where the fasting blood glucose exceeded 4.0 mmol/l. The cut-off levels were exceeded in 22 cases, but only one of these women was found to be suffering from previously unsuspected diabetes mellitus, based on the criteria of WHO (1). Five other cases of gestational diabetes were not detected by the random blood glucose method. It is concluded that random blood glucose measurements cannot be recommended as a safe and reliable screening procedure during the early part of the second trimester.

Adult↗