Hadley protests.
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National Institutes of Health (U.S.)↗
Biomedical subjects
S W Hadley
Publications and source records attributed to S W Hadley.
Specific vs nonspecific factors in psychotherapy. A controlled study of outcome.
This study explored the relative contribution of the therapist's technical skills and the qualities inherent in any good human relationship to outcome in time-limited individual psychotherapy. Highly experienced psychotherapists treated 15 patients drawn from a relatively homogeneous patient population (male college students, selected primarily on the basis of elevations on the depression, anxiety, and social introversion scales of the Minnesota Multiphasic Personality Inventory). By traditional diagnostic categories, they would be classified as neurotic depression or anxiety reactions. Obsessional trends and borderline personalities were common. A comparable patient group was treated by college professors chosen for their ability to form understanding relationships. Patients treated by professors showed, on the average, as much improvement as patients treated by professional therapists. Treated groups slightly exceeded the controls. Group means, however, obscured considerable individual variability.
Adjustment Disorders↗
Individual psychotherapy and behavior therapy.
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Age Factors↗
A tripartite model of mental health and therapeutic outcomes. With special reference to negative effects in psychotherapy.
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Affect↗
Contemporary views of negative effects in psychotherapy. An integrated account.
As part of a larger investigation into negative effects in psychotherapy, we conducted a survey of researchers and practitioners in psychotherapy. We now present an integrated account of the consensus of these experts on the following issues: (1) Is there a problem of negative effects? (2) What constitutes a negative effect? (3) What factors are prominently associated with negative effects? There was an overwhelming affirmation of the reality of negative effects among the respondents. Furthermore, they urged that negative effects be subjected to systematic research scrutiny, a strategy made more feasible by the identifying criteria and possible causative factors cited by these experts. It is suggested that there is need for research into therapeutic actions and psychotherapy outcomes in general, with special reference to negative effects.
Attitude of Health Personnel↗
Some effects of a model's performance on an observer's electromyographic activity.
It is suggested that motor reactions may be elicited in an observer as a consequence of his exposure to a model and that such reactions may become conditioned to environmental events. An experiment is reported in which observers showed greater EMG activity in the arm while watching models arm wrestle than while watching a model stutter, and greater lip EMG activity while watching a model stutter than while watching arm wrestling. Some evidence for conditioning was found in the arm activity of males watching wrestling.
Adolescent↗
Radioiodinated iodobenzoyl conjugates of a monoclonal antibody Fab fragment. In vivo comparisons with chloramine-T-labeled Fab.
A comparative investigation of the biodistributions of radioiodinated p- and m-iodobenzoyl conjugates of a monoclonal antibody Fab fragment, NR-LU-10 Fab, and the same antibody Fab fragment radioiodinated by the chloramine-T (ChT) method has been carried out in mice. Coinjected, dual-isotope studies in athymic mice with tumor xenografts have demonstrated that there are only minor differences in the in vivo distributions of the iodobenzoyl-labeled Fabs, except in the excretory organs, kidneys, and intestines, where major differences were observed. Similarly, coinjection of either the p-iodobenzoyl or m-iodobenzoyl conjugate of NR-LU-10 Fab with the Fab radioiodinated with ChT/radioiodide into BALB/c mice provided additional data that indicated that the two iodobenzoyl conjugates distributed similar in a number of selected tissues. The tissue-distribution differences of the regioisomeric iodobenzoyl conjugates in relation to the ChT-radioiodinated Fab were large for the stomach and neck, consistent with previous studies. The most notable difference between the two iodobenzoyl conjugates was the kidney activity, where the m-iodobenzoyl conjugate was similar to the directly labeled Fab, but the p-iodobenzoyl-conjugated Fab was higher by nearly a factor of 2.
Animals↗
Preparation and in vivo evaluation of an N-(p-[125I]iodophenethyl)maleimide-antibody conjugate.
Protein sulfhydryl reactive N-(4-[125I]iodophenethyl)maleimide (IPEM, 5) was obtained from N-[4-(tri-n-butylstannyl)phenethyl]maleimide in 59-100% radiochemical yield. Conjugation of 5 to NR-ML-05 Fab, a murine anti-melanoma antibody Fab fragment that had been previously reduced with dithiothreitol (DTT), was effected in an average of 85% yield. Results from in vitro chemical challenges and serum stability studies on the IPEM conjugate of NR-ML-05 Fab (6) indicated a stable covalent attachment of the radioiodine. A biodistribution study of the IPEM conjugate in tumor-bearing athymic nude mice showed lack of significant accumulation of radioiodine in the thyroid and stomach which was an indication of in vivo stability. The observed uptake in tumor was consistent with that obtained for Chloramine-T- or p-iodobenzoate-labeled NR-ML-05 Fab conjugates.
Animals↗