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Biomedical subjects

S W Keele

Publications and source records attributed to S W Keele.

12 recordsLinked to original sources
PubMed2000

Changing internal constraints on action: the role of backward inhibition.

Flexible control of action requires the ability to disengage from previous goals or task sets. The authors tested the hypothesis that disengagement during intentional shifts between task sets is accompanied by inhibition of the previous task set ("backward inhibition"). As an expression of backward inhibition the authors predicted increased response times when shifting to a task set that had to be abandoned recently and, thus, suffers residual inhibition. The critical backward inhibition effect on the level of abstractly defined perceptual task sets was obtained across 6 different experiments. In addition, it was shown that backward inhibition can be differentiated from negative priming (Experiment 2), that it is tied to top-down sequential control (Experiment 3), that it can account at least partially for "residual shift costs" in set-shifting experiments (Experiment 4), and that it occurs even in the context of preplanned sequences of task sets (Experiment 5).

Adult↗
PubMed1998

Toward a functional analysis of the basal ganglia.

Parkinson patients were tested in two paradigms to test the hypothesis that the basal ganglia are involved in the shifting of attentional set. Set shifting means a respecification of the conditions that regulate responding, a process sometimes referred to as an executive process. In one paradigm, upon the appearance of each stimulus, subjects were instructed to respond either to its color or to its shape. In a second paradigm, subjects learned to produce short sequences of three keypresses in response to two arbitrary stimuli. Reaction times were compared for the cases where set either remained the same or changed for two successive stimuli. Parkinson patients were slow to change set compared to controls. Parkinson patients were also less able to filter the competing but irrelevant set than were control subjects. The switching deficit appears to be dopamine based; the magnitude of the shifting deficit was related to the degree to which 1-dopa-based medication ameliorated patients' motor symptoms. Moreover, temporary withholding of medication, a so-called off manipulation, increased the time to switch. Using the framework of equilibrium point theory of movement, we discuss how a set switching deficit may also underlie clinical motor disturbances seen in Parkinson's disease.

Aged↗
PubMed1988

Dissociation of the lateral and medial cerebellum in movement timing and movement execution.

In a previous study (Ivry and Keele, in press), cerebellar patients were found to be impaired on both a motor and a perceptual task which required accurate timing. This report presents case study analyses of seven patients with focal lesions in the cerebellum. The lesions were predominantly in the lateral, hemispheric regions for four of the patients. For the remaining three patients, the lesions were centered near the medial zone of the cerebellum. The clinical evaluation of the patients also was in agreement with the different lesion foci: lateral lesions primarily impaired fine motor coordination, especially apparent in movements with the distal extremities and medial lesions primarily disturbed balance and gait. All of the patients were found to have increased variability in performing rhythmic tapping when tapping with an effector (finger or foot) ipsilateral to the lesion in comparison to their performance with a contralateral effector. Separable estimates of a central timekeeper component and an implementation component were derived from the total variability scores following a model developed by Wing and Kristofferson (1973). This analysis indicated that the poor performance of patients with lateral lesions can be attributed to a deficit in the central timing process. In contrast, patients with medial lesions are able to accurately determine when to make a response, but are unable to implement the response at the desired time. A similar dissociation between the lateral and medial regions has been observed on a time perception task in patients with cerebellar atrophy. It is concluded that the lateral regions of the cerebellum are critical for the accurate functioning of an internal timing system.

Adult↗
PubMed1988

Tests of a temporal theory of attentional binding.

Different features of stimuli present in the field of view appear to be registered in different cortical maps. How, then, are the features that come from the same object bound together rather than mistakenly assembled with features coming from other simultaneously present objects? One theory supposes that an attentional mechanism intercepts input coming from particular retinal locations at a way station prior to parsing of the features from the same object. Any enhancement (or facilitation) at that stage will cause all the features from that object to be modified simultaneously in the downstream registers. The imposed temporal synchronicity serves as the essential binding cue. Five experiments provided no support for the theory. There is no tendency for synchronicity of features to cause binding unless the features come from the same location. Location, rather than temporal synchronicity, appears to be the essential cue for binding.

Attention↗
PubMed1982

Explorations of individual differences relevant to high level skill.

Past research has uncovered few broad abilities that underlie high skill. In this paper, attempts to isolate three different abilities of potential relevance to skill are described. No evidence was found for a general time-sharing ability in common to different kinds of tasks. Modest evidence was found for a trait of attentional flexibility. That trait could potentially be of use in predicting success for skills that require rapid shifts of attention because of rapidly changing task demands. Finally, the rate of repetitive activity is correlated across different muscle groups. For example, finger tapping speed is correlated with foot tapping speed, suggesting a common rate limiting factor. In turn, those rates predict handwriting speed and, according to Book (1924), championship typing.

Journal Article↗
PubMed1967

Decay of visual information from a single letter.

If the trace of a letter can be matched more rapidly with a physically identical letter (as in the pair AA) than it can be with a letter having only the same name (as in the pair Aa), then the trace must preserve the visual aspect of the letter. The visual information from a single letter decays in about 1.5 seconds if the task provides little incentive for preservation.

Humans↗