Biomedical subjects
S W Sandler
Publications and source records attributed to S W Sandler.
The use of human chorionic gonadotropin in recurrent abortion.
Important unresolved problems associated with recurrent abortion are aetiology, prognosis and management. This communication describes hormonal monitoring in pregnancy of groups of patients treated with human chorionic gonadotropin (HCG). The outcome is compared with that in an untreated normal group and an untreated group with recurrent abortions.
Spontaneous abortion in perspective. A 7-year study.
Ten per cent of all pregnancies end in spontaneous abortion. Only by thorough history taking, physical examination and selected biochemical and biological investigations can potential causes of abortion be recognized and treated. The lesser known factors concerned with abortion are emphasized, and the role played by human chorionic gonadotrophin therapy in selected cases is considered.
Plasma hormone levels, cervical mucus, and vaginal cytology in normal pregnancy.
Plasma oestradiol (E2), oestriol (E3), progesterone (P), human chorionic gonadotrophin (HCG) and human placental lactogen (HPL) levels, karyopyknotic index (KPI) and cervical mucus pattern were studied serially throughout pregnancy in 17 normal women. Hormonal patterns were similar to those reported by previous investigators. The P/E2 and P/E3 ratios were high in the first trimester but remained constant thereafter until term. There was no consistent change in E2, E3, and P levels and in P/E2 and P/E3 ratios in relation to onset of labour. With 2 exceptions, the cervical mucus and vaginal cytology were normal for pregnancy. The study provides a basis for a subsequent investigation into hormonal changes in threatened and recurrent abortions and the effect of treatment with HCG.
Effect of detergents on 2',3'-cyclic nucleotide 3'-phosphohydrolase activity in myelin and erythrocyte ghosts.
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Human chorionic gonadotropin (HCG) in threatened abortion.
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A preliminary report on the management of high risk patients.
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