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S W Shen

Publications and source records attributed to S W Shen.

8 recordsLinked to original sources
PubMed1987

Iodine-131 MIBG scintigraphy of the extremities in metastatic pheochromocytoma and neuroblastoma.

Iodine-131 MIBG scintigraphy may be used to determine the presence or absence of metastases to the appendicular skeleton in malignant pheochromocytoma and neuroblastoma. Normal bones show no uptake of [131I]MIBG and the joints are seen as photon-deficient areas surrounded by background muscle activity. Discrete concentrations of radioactivity in bone are often seen in patients with malignant pheochromocytoma and neuroblastoma. Bone marrow involvement in neuroblastoma may be indicated by diffuse uptake of [131I]MIBG or focal accumulation at the metaphyses. Uncommonly, bone involvement may not be displayed by the [131I]MIBG images. Since conventional bone scanning agents may also fail to detect these tumors, skeletal scintigraphy with both [131I]MIBG and [99mTc]MDP is necessary to reliably stage malignant pheochromocytoma and neuroblastoma.

3-Iodobenzylguanidine↗
PubMed1977

Hypoglycemia.

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Humans↗
PubMed1975

Serum dopamine-beta-hydroxylase activity in parents and children.

Dopamine-beta-hydroxylase (DBH), an enxyme catalyzing the final step in the synthesis of norepinephrine, is released with norepinephrine on stimulation of the sympathetic nervous system. In this study an enzymatic colorimetric method was used to assay serum DBH activity in 196 individuals of whom 169 were either the parents or children in 29 families. We examined the association of DBH with age and with hypertension and the faamilial pattern of distribution of serum DBH activity. Serum DBH activity was highest in te groups 10 to 14, 40 to 49, and over 60 years. There was no significant difference in serum DBH activity between normal subjects and individuals with hypertension in any age group. tfurthermore, there was no significant correlation of mean blood pressure with serum DBH activity with or without correction of DBH for age differences; Highly significant correlations of serum DBH activity were found in sibling-sibling pairs and in mean parent-child pairs. No significant correlations were found for father-mother pairs. These observations suggest that the contribution of heredity is more important that shared environment in determining the familial pattern of distribution of serum DBH activity. Serum DBH activity did not have a bimodal distribution in the population. Noevidence was found for a maternal influence or for sex linkage in the transmission of this trait. Our data, derived from this study restricted to families with only two generations, are not adequate to specify with confidence the mode of inheritance of DBH activity in the general population.

Adolescent↗
PubMed1975

Disordered glucose and insulin metabolism in patients with insulinoma.

The response of plasma glucose and insulin to infusion of glucose and of epinephrine plus propranolol were examined in normal subjects and in two patients with surgically proven insulin-secreting islet cell tumors. The plasma immunoreactive insulin concentration in the two patients was both inappropriate and independent of the plasma glucose concentration. Their insulin secretion was neither increased by physiologic stimulants nor decreased by pharmacologic inhibitors of insulin secretion. There are diagnostic uses for these data as well as theoretical implications. We propose a physiological approach to establish the diagnosis of insulin-secreting islet cell tumors.

Adenoma, Islet Cell↗