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Biomedical subjects

S W Wassilew

Publications and source records attributed to S W Wassilew.

At least 19 recordsLinked to original sources
PubMed1991

[Treatment of recurrent herpes labialis using a herpes simplex Type-I subunit vaccine. A prospective randomized double-blind multicenter study].

A herpes simplex type I subunit vaccine developed by Behring-Werke (Marburg/Lahn, FRG) was compared with placebo for therapeutic effectiveness in the treatment of recurrent orolabial herpes simplex in a multicentre study involving the major hospitals in Frankfurt/Main (n = 34), Hamburg (n = 18), Giessen (n = 17) und Kassel (n = 14). The effectiveness of the vaccine was judged on the reduction in the frequency of recurrences. Within the period of the 8-month study there was no statistically significant difference in the frequency of recurrences with vaccine or placebo. Both placebo and verum led to a significant decrease in the number of recurrences of orolabial herpes simplex, but the effect of placebo was slightly more pronounced.

Adult↗
PubMed1990

[Ixodes ricinus bites].

Ticks (Ixodes ricinus) are found all over the world, with special preference of a few epidemic areas. They do not only invade their hosts one by one, but often in large groups.

Animals↗
PubMed1989

[Current topics in mycology].

There is an urgent need of in vitro test methods with a good in vivo predictability both for the search of new antimycotics moderate in price and for the susceptibility testing of yeasts in antimycotic therapy. We discuss the problems of agar dilution test methods. Usually, the minimal inhibitory concentration (MIC) is measured. This parameter does not only depend on the susceptibility of the test fungus, but is greatly influenced by other factors such as inoculum size, incubation time, and culture medium. Thus the MIC of azoles can vary considerably. Moreover, the current test methods are not adjusted to the different ways of fungus growing in vitro and in vivo.

Antifungal Agents↗
PubMed1989

[Infections of the skin caused by gram-negative pathogens. Foot infections--wound infections--folliculitis].

Gram-negative bacilli are ubiquitous. They are found in 10-15% of the intertriginous bacterial flora and the most important one is Pseudomonas aeruginosa. Heat, moisture, mazeration, and reduction of the normal Gram-positive flora favor a rapid establishment of Gram-negative bacilli and the ensuing development of clinical infections. The diagnosis depends of the characteristic clinical features and localization, the patient's history, as well as the result of bacteriological investigation. The significance of the isolation of Gram-negative bacilli from non-specific lesions must be carefully evaluated. Cutaneous lesions respond well to therapy if they can be dried. Systemic antibiotics acting against Gram-negative bacilli have been found helpful. In patients with acne and Gram-negative folliculitis, isotretinoin has a good effect.

Bacterial Infections↗
PubMed1988

[Skin changes in syringomyelia].

Asymmetric anonychia, skin edema, and painless ulceration of the fingers may be the first symptoms of syringomyelia. Neurologic examination of the patient leads to the diagnosis, which can be proved by the demonstration of the cavity in the central spinal cord. Prophylactic dermatologic treatment may prevent the progression of the skin lesions.

Biopsy↗
PubMed1988

[Experimental study of the effect of raw materials of the neem tree and neem extracts on dermatophytes, yeasts and molds].

In traditional Indian medicine, various parts of the neem tree have been used for centuries, especially with skin diseases. These products are often applied in human mycoses. We tested some dried neem materials, neem oils as well as simple neem preparations and extracts with regard to their effect on 14 of the most common pathogenic fungi. Neither the dried neem materials nor the medical preparations and oils had any effect on fungal growth; most of them were even contaminated with molds. Some of the extracts, however, showed antimycotic properties, which decreased with rising solvent polarity. Petrolether leaf extract proved most effective. One of the possible explanations might be the fact that it contains quercetin, a flavonoid.

Dermatomycoses↗
PubMed1988

[Injuries caused by stingrays].

We report on an injury caused by the bite of a South American freshwater stingray. Although wide excision is the therapy of choice, prolonged healing must be expected. We give some information on the mode of injury and biological data regarding the genus protamotrygon. This stingray may also be bred in aquariums.

Animals↗
PubMed1987

Oral acyclovir for herpes zoster: a double-blind controlled trial in normal subjects.

Sixty immunocompetent patients with herpes zoster of various dermatomes were treated 5 times a day for 5 days with either acyclovir at a dose of 400 mg or placebo. Acyclovir was shown to reduce significantly the time to full crusting (P = 0.02). There were also trends in favour of acyclovir for time to first dry vesicle and time to first day without macules or papules, but these were not statistically significant. There were no differences between the groups in the occurrence of adverse events or postherpetic neuralgia.

Acyclovir↗
PubMed1986

[Value of glucocorticoid treatment in herpes zoster].

48 patients suffering from severe acute zoster pain were treated with methylprednisolone 1 mg/kg body weight daily, if bed rest and analgetics had not been effective. The pain completely vanished in 33.3% of the patients; only 20.9% still suffered from unaltered pain. This therapy proved only to be effective if it was applied during the first 5 to 10 days after the appearance of the first lesions. There was no exacerbation observed in any patient. 66.6% of the patients developed postherpetic neuralgia accompanied by rather low pains, as 61.8% of the patients did not need analgetics.

Aged↗
PubMed1986

[Virostatics in dermatology].

Many antiviral substances are known, but only a few are clinically effective in certain disease resulting from herpes virus infections. Early diagnosis is essential. Antiviral chemotherapy is discussed in respect to herpes infections in immunocompetent patients, and in patients with primary genital herpes, eczema herpeticum, genital and gluteal recurrent herpes and herpes zoster.

Acyclovir↗
PubMed1980

[Clinical aspects and importance of human herpex simplex infections. Results of herpes antigen therapy].

Herpes simplex diseases are among the most frequent sociomedical problems of our age. For the patients the recurrent diseases are particularly distressing depending on the frequency of relapse, their localization and clinical course. Immunological factors, especially cellular immune mechanisms seem to affect the frequency of relapse and particularly the clinical course of the relapse. Clinical experience so far with immunotherapy of relapsing herpes diseases with heat-inactivated herpes simplex virus antigen type 1 and type 2 are optimistic. Local painful swellings or more rarely the appearance of an urticaria have been described as side-effects within 10 years in 1 to 2% of patients.

Antigens, Viral↗
PubMed1979

[Combined chemotherapy of herpes simplex infections of the skin].

It was possible to prolong the herpes free intervals with combined chemotherapy with 0,3% Ethyl-desoxyuridine (EDU)-Gel during the acute phase and continued application of 0,2% Jodo-desoxyuridine (IDU)-ointment with 1,8% DMSO. The combined chemotherapy did not improve the effect of the treatment with EDU alone in respect of the duration of skin lesions. In 5 out of 8 patients with recurrent cold sores and in 3 out of 10 patients with genital herpes further immunotherapeutical measures were not necessary. The results indicate that beside the chemotherapy of the recurrences with monotherapy a continuous chemoprophylaxis can be successful in patients with recurrent herpes simplex.

Adult↗
PubMed1979

[New possibilities of drug therapy for herpes simplex infections of the skin].

Jodo-desoxyuridine (IDU) of different concentrations in different vehicles can shorten the duration of primary infections and recurrences of herpes simplex virus (HSV) infections to about one third. Therapeutical failures can be due to the development of IDU resistence. Ethyl-desoxyuridine (EDU) in a gel base was found to reduce the mean duration of acute herpetic lesions to about 50%. 42 recurrences of 16 patients with herpes labialis and 36 recurrences of 10 patients with herpes genitalis were observed and statistically evaluated. In cold sores 0,3% EDU-gel had similar effects as the 2,0% EDU-gel, what shortened significantly (0,001 less than p less than 0,01) the duration of skin lesions. In herpes genitalis both concentrations had good effects. 0,3% EDU-gel reduced the healing time significantly (p less than or equal to 0,05). Remarkable was the quick disappearence of subjective complaints in all treated patients. Side effects were not observed.

Adult↗