Biomedical subjects

S WOLFE

Publications and source records attributed to S WOLFE.

15 recordsLinked to original sources

PubMed1965

TRENDS IN THE SUPPLY AND DISTRIBUTION OF PHYSICIANS IN SASKATCHEWAN: JANUARY 1962 TO JUNE 1964.

Using all the readily available sources of information, a study was designed to describe the changes in supply and distribution of physicians in Saskatchewan during the inception of the Province's controversial Medical Care Insurance Act. Baselines were obtained in January 1962, and comparisons made in June 1963 and June 1964. The physician:population ratio was 1:1037 in January 1962 and 1:980 in June 1964. The average yearly physician turnover rate of 10% was exceeded in 1960 and in 1961 and then levelled off. The levelling off continued from January 1962 to June 1963. But between June 1963 and June 1964 the total number of physicians was sufficient both to re-establish the rising trend of the previous decade and to offset some of the losses of 1960-1962.

Canada↗

PubMed1965

SOME CHARACTERISTICS OF PERSONS HOSPITALIZED IN SASKATCHEWAN BECAUSE OF HEART DISEASE INVOLVING THE CORONARY ARTERIES.

A retrospective study was designed to determine the background characteristics of 9562 patients hospitalized in Saskatchewan during the calendar years 1958-1959-1960 with a discharge diagnosis of heart disease specified as involving the coronary arteries. The study illustrates the limitations of retrospective analyses, but points out that such analyses may highlight presumptive relevant variables in the search for causes of diseases with multiple possible interacting origins. Single persons, and in particular single females, were significantly much less susceptible than were persons who were married or who had been married. This is a previously unreported finding, to the authors' knowledge. Residents of farms and hamlets were hospitalized significantly less often than were village, town or city residents; it is suggested that this may corroborate the findings of Morris and others who feel that the physical activity of work may be a relevant variable in the etiology of coronary heart disease.

Adolescent↗

PubMed1964

INHIBITION OF PROTEIN SYNTHESIS IN MAMMALIAN CELL-FREE SYSTEMS BY CHLORAMPHENICOL.

Chloramphenicol can inhibit protein synthesis in mammalian cell-free systems as effectively as it inhibits protein synthesis in analogous microbial systems. Significant inhibition in mammalian systems was obtained only when protein synthesis was stimulated by the addition of template RNA to the system, there being comparatively little inhibition of protein synthesis by ribosomes in the absence of stimulatory RNA. It is postulated that chloramphenicol may inhibit the function of messenger or template RNA by successfully competing for ribosomal binding sites, thereby preventing the attachment of RNA to ribosomes. The apparent discrepancy in the sensitivity of mammalian and microbial cells to chloramphenicol may be related to differences in turnover or stability of ribosomal template RNA rather than to intrinsic differences in mechanism of protein synthesis. These observations are in accord with the suggestion that protein synthesis in intact mammalian cells may be susceptible to chloramphenicol inhibition only at the time that new messenger or template RNA is being deposited on ribosomes and that more mature cells may be resistant because informative RNA already deposited on ribosomes is not accessible to chloramphenicol inhibition. The inhibitory effect of chloramphenicol on protein synthesis in proliferating cells may be an important factor in hematologic toxicity attributable to chloramphenicol.

Animals↗

PubMed1964