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Biomedical subjects

S Wahlgren

Publications and source records attributed to S Wahlgren.

10 recordsLinked to original sources
PubMed1984

Liquid crystals as a potential ointment vehicle.

A lecithin-water lyotropic liquid crystal was used as an ointment vehicle for a hydrocortisone formulation. The hydrocortisone was soluble in the liquid crystalline phase up to 5% by weight. The diffusion coefficient determined for the hydrocortisone in the liquid crystalline phase was 5.5 X 10(-9) cm X s-1, which is four magnitudes higher than the corresponding value for skin.

Chemistry, Pharmaceutical↗
PubMed1979

[Studies on suspension ointments. Part 2: The Diffusion of salicylic acid as influenced by the colloid chemical properties of the vehicle (author's transl)].

A comparative study of the solubility and the diffusion of salicylic acid in two hydrocarbon gels (Plastibase, vaseline) has been made. It was found that there was no difference in solubility, whereas the diffusion rate was greater in Plastibase. The solubilities and the diffusion rates were identical in the liquid components of the gels. The difference in diffusion rate between the two gels is attributable to the different properties of the solids in the gels. The greater in vitro diffusion rate in Plastibase results in a more rapid drug release in vivo. Suspension ointments may be regarded as saturated solutions with an excess of the drug in suspension. For this reason, the studies were undertaken mainly on saturated solutions.

Chemistry, Pharmaceutical↗