Biomedical subjects

S Waikakul

Publications and source records attributed to S Waikakul.

At least 19 recordsLinked to original sources

PubMed2001

Malignant peripheral nerve sheath tumor with neurofibromatosis type 1: a 2-case report and review of the literature.

Malignant peripheral nerve sheath tumor is a very rare soft tissue tumor in the general population but there is an increased incidence in patients with neurofibromatosis type 1. Two cases of malignant peripheral nerve sheath tumor associated with neurofibromatosis type 1 whom we were able to follow-up long term are presented. Although wide excision was performed successfully in these patients, they suffered from local recurrence of the tumors shortly after surgery and died with distant metastases. The literature concerning the natural history and the management of this specific condition was reviewed.

Adult↗

PubMed2000

Results of 1018 digital replantations in 552 patients.

To find out the influencing factors of the immediate and late outcome of replantation and revascularization of the digits the study was carried out as a prospective survey research during 1983 to 1995 with at least 2 year follow up. Traumatic total or subtotal amputation with inadequate circulation of the digits distal to the metacarpal head were included in the study. There were 552 patients with 366 males (675 digits) and 186 females (343 digits). Successful operation was found in 508 patients (92%) with 946 digits (92.9%). Type of injury was the most important factor influencing immediate and late outcome. Regular cigarette smoking resulted in poor immediate survival rate. Prolonged ischaemia had a significant influence in final functional outcome. Using composite skin and subcutaneous vein graft gave good survival rate. Injury at the no man's land area resulted in poor range of movement of the digit. Connecting the profundus tendon stump of the proximal part to the superficialis tendon of the amputated part gave a better result than 2 tendon repair and repairing only the profundus tendon. Replantation should be carried out even if only one digit is involved. At the 2 year follow up 195 patients (38%) were classified in grade I of Chen et al., functional outcome, while 153 (31%) were in grade II, 124 (24%) were in grade III and 36 (7%) were in grade IV.

Adolescent↗

PubMed2000

Brachial plexus injury and pain: incidence and the effects of surgical reconstruction.

A prospective study of pain after brachial plexus injury was carried out on 246 patients with at least 2 years follow-up. All of them had closed traction injury from motorcycle accidents. There were 16 females and 230 males aged from 16 to 44 years old. The patients' biodata, onset of pain, characteristics of pain and treatment were recorded. Changes in pain after conservative and operative treatment and the outcome of treatment were analysed. Two hundred and nineteen patients (89%) had significant pain and 182 patients (74%) had severe pain. Most of them had continuous pain with 2 to 20 peaks of severe pain per day. Crushing type of pain was the most common but mixed type of pain caused the most distress. Conservative treatment before surgery could relieve the pain in 39 patients (15.8%). Surgical reconstruction could further relieve the pain in 176 patients (80.36%). However, 21 patients (8.5%) still had severe pain. Improvement in sensory function had more effect on pain reduction than motor function.

Adolescent↗

PubMed2000

Methylcobalamin as an adjuvant medication in conservative treatment of lumbar spinal stenosis.

To find out the clinical effects of methylcobalamin on the conservative treatment of degenerative lumbar spinal stenosis, the study was carried out as a control single blind trial with 2 year follow-up in 152 patients, 68 males and 84 females, whose ages ranged from 55 to 85 years, average 67 +/- 18.1 years. They were randomly allocated into 2 groups, the control group, 82 patients, and the methylcobalamin group, 70 patients. All had classical history, and physical and radiographic findings which confirmed the diagnosis of spinal stenosis. Conventional management, including patient education, physical therapy and medication, were carried out in every patient and in addition methylcobalamin 0.5 mg was given orally three times a day in the methylcobalamin group for 6 months. All patients were followed up periodically for 2 years. Most of the patients in both groups showed improvement but there was no significant difference between the 2 groups in terms of pain improvement and neurological signs, except neurogenic claudication distance which was better in the M-group.

Aged↗

PubMed2000

The effects of patellar resurfacing in total knee arthroplasty on position sense: a prospective randomized study.

To find out the improvement of joint position sense after total knee arthroplasty with patellar resurfacing compared to total knee arthoplasty without patellar resurfacing, the study was carried out as a randomised parallel trial in patients who had stage III and IV primary osteoarthrosis of only 1 side of the knee with a 2 year follow-up. Twenty-one patients underwent patellar resurfacing and 26 patients had no patellar resurfacing. Joint position sense was evaluated by the average absolute different angle of the operated knees from the non operated knees which was the asymptomatic knee and acted as the reference knee. Position sense was improved significantly in both groups. However, the patients without patellar resurfacing had better improvement. The patients with patellar resurfacing had better results in terms of anterior knee pain and tenderness. Patellar resurfacing should be used in severe articular cartilage damage, not as a routine operation.

Aged↗

PubMed1999

Revascularization of subtotal amputation at the ankle in children following motorcycle-spoke injury.

A prospective study of subtotal amputation of the ankle following motorcycle spoke injury was carried out to define the mechanism of the injury and results of revasculization. Between 1990 to 1995, there were 42 patients with this type of injury. They were 31 boys and 11 girls. All sustained severe skin lacerations, medial, posterior, lateral and anterior to the ankle joint. All tendons and neurovascular bundles medial, lateral and anterior to the ankle were completely torn, leaving tendons of anterior tibial, extensor hallucis longus and extensor digitorum communis intact. Revascularization was performed successfully in 38 patients. All had good functional outcome although varus of the distal tibia, limitation of ankle motion, shortening of the foot and limb length discrepancy were observed. The motorcycle wheel needs to be redesigned.

Accidents, Traffic↗

PubMed1999

Restoration of elbow flexion in brachial plexus avulsion injury: comparing spinal accessory nerve transfer with intercostal nerve transfer.

This study was performed to compare the clinical outcome of 2 types of commonly used nerve transfers, the spinal accessory nerve transfer and the intercostal nerve transfer. This study was a prospective randomized parallel trial involving 205 patients presenting between 1989 and 1994. All patients were males ranging in age from 16 to 43 years. All patients underwent surgery within 6 months of injury. Spinal accessory nerve transfer was performed in 130 patients; better results were obtained in terms of less operative time, fewer blood transfusions, fewer immediate complications, and better motor function (very good and good power in 83% of patients). Intercostal nerve transfer was performed in 75 patients; better results were observed in terms of earlier electromyographic evidence of motor reinnervation, improvement in protective sensation, and reduction of pain. However, very good and good motor recovery was observed in only 64% of patients. There was no significant difference with regard to tidal volume, vital capacity, and the FEV1 to FEV ratio before and after surgery in either group. Smoking adversely affected the rate of recovery. Spinal accessory nerve transfer should be used when motor function of the elbow flexors is the major concern. Intercostal nerve transfer should be performed in patients who need both motor and sensory reconstruction and in those who have chronic pain syndrome after brachial plexus injury.

Adolescent↗

PubMed1999

The role of allopurinol in digital replantation.

The clinical effects of allopurinol on the attenuation of reperfusion injury in thumb replantations after prolonged ischaemic time were studied in a randomized control trial with a 2-year follow-up. There were 60 patients, in the trial group, and 38 patients in the control group. All were young, healthy labourers who had sharp or locally crushed amputations of the thumb at the proximal phalanx with a total ischaemic time of more than 10 hours. The standard management for thumb replantation was used in these patients, except that 300 mg allopurinol was given orally in the trial group on admission and a further 300 mg for another 5 days. After operation, the trial group had a lower infection rate, and less postoperative pain and chronic swelling than the control group. Recovery of sensation was also better in the trial group.

Adolescent↗

PubMed1999

Clinical results of contralateral C7 root neurotization to the median nerve in brachial plexus injuries with total root avulsions.

This prospective study was carried out to assess motor and sensory recovery after contralateral C7 root to median nerve neurotization in brachial plexus injuries with total root avulsions. The survey was carried out from 1993 to 1995 and the patients were followed up for at least 3 years. There were 96 male patients with ages ranging from 13 to 48 years. All had a unilateral brachial plexus injury with avulsion of all roots. This was confirmed by clinical assessment and exploration. The anterior part of the contralateral C7 root was used for neurotization via a reversed pedicular ulnar nerve graft and the proximal end of the graft was connected to the median nerve. Furthermore, phrenic nerve to suprascapular nerve and spinal accessory nerve (via a sural nerve graft) to musculocutaneous nerve neurotizations were also carried out to obtain shoulder abduction and elbow flexion. At the 3 year follow-up, most patients had encouraging recovery of sensory function in the hand but motor function of the forearm and hand muscles was rather poor. Acceptable motor function was found in only 50 to 60% of the patients who were younger than 18 years.

Adolescent↗

PubMed1999

Anterior stabilization in the pubic symphysis separation: a mechanical testing.

Four types of commonly used instruments, 1) external fixation, 2) tension wiring, 3) tension band wiring, and 4) single superior plating, for anterior stabilization of the diastasis pubic symphysis were tested for their mechanical properties under single load to failure in cadaveric pelvis by a universal testing machine. Three directions of loading, transverse tension, vertical tension and saggital compression, were used to test each type of instrumentation. Five specimens of each fixation were used for each direction of testing. The strongest instrumentation was single superior plating. Early mobilization can be advocated in the patient after fixation with this instrument. External fixation could resist transverse and saggital compression load at an acceptable level but not the vertical load. Tension band wiring could better resist vertical load than the other directions. Tensions wiring was the weakest instrumentation and early ambulation should be avoided.

Adolescent↗

PubMed1999

Immediate stabilization of unstable pelvic fractures versus delayed stabilization.

To compare the immediate and long term outcome of immediate stabilization of the unstable pelvic fractures to delayed stabilization with simple external fixation, the study was carried out as a paralell trial with 2 year follow-up. There were 112 patients with 69 males and 43 females who had unstable pelvic fractures. They were allocated randomly into 2 groups. In group 1, 40 patients, conventional management was performed while in group 2, 72 patients, reduction and anterior stabilization of pelvic fractures with a simple external fixator were carried out immediately just after the unstable fractures were detected. Blood transfusion, post operative pain, need of reconstructive surgery of the pelvic fractures and late deformities were less in the group 2. Immediate anterior reduction and stabilization of the unstable pelvic fractures gave encouraging results.

Adult↗

PubMed1999

A post marketing survey on the side-effects of loxoprofen.

A survey study of the efficacy and side-effects of loxoprofen in orthopaedic outpatient clinics was carried out from January 1995 to December 1997. There were 1206 patients (569 males and 637 females) with an average age of 56.4 +/- 14.9 years. The youngest was 43 and the oldest was 79 years. About 36 per cent of the patients had underlying diseases and 31 per cent were receiving other medications as well as loxoprofen. About 91 per cent of the patients were satisfied with loxoprofen in terms of pain control and decreased inflammation. However, 8.4 per cent had side-effects, the most common being GI and CNS disturbances. Some patients (0.24%) had GI bleeding and needed hospitalization. The high risk patients were female older than 60 years who had used loxoprofen continuously for more than 6 weeks. However, we conclude that loxoprofen is an effective NSAID with few side-effects.

Administration, Oral↗

PubMed1999

Recovery of joint position sense after total knee replacement: the effects of soft tissue dissection.

To find out the effect of sharp dissection compared to electrocautery for soft tissue release and balancing in total knee replacement on proprioceptive sense, the study was carried out as a parellel double blind trial with 2 year follow-up. There were 52 patients in the sharp dissection group and 42 patients in the electrocautery group. Position sense of the operated knees was evaluated by the ability to reproduce the same angles as the non operative knees which acted as reference knees. The absolute different angles were used to evaluate the position sense. Before the operation, the patients in both groups had similar biographic data, pathology, and absolute different angles of knee positioning. After the operation, both groups had improvement in knee position sense; however, the sharp dissection group had more rapid improvement in the 1st post operative year. There was no significant difference at the 2 year follow-up.

Aged↗

PubMed1998

An aiming device for pin fixation at the iliac crest for external fixation in unstable pelvic fracture.

To improve the accuracy of pinning at the iliac crest during external fixation of the pelvic fracture, an aiming device has been designed. The device consists of 3 parts: a sleeve which accommodates a 5.0 Shanz pin, a handle and guide points. The guide points were designed to grasp the iliac crest to allow proper pin fixation. The device has undergone trials to fix Shanz pins on the iliac crests of 10 cadavers by 10 recently graduated doctors. All pins were fixed in proper position and passed into the bone between the two tables of the iliac crest without penetrating the tables. The device has so far been used in 50 patients who had unstable pelvic fractures. All pins were in the proper positions and there had been no loosening at the time the pins were removed. The use of this aiming device for pinning the iliac crest for external fixation of pelvic fracture has given encouraging results.

Adult↗

PubMed1998

Relationship between foot length and the inter anterior superior iliac distance.

Reduction of unstable pelvic fracture by external fixator might be over or under corrected as there is no proper estimation from the surgical landmark. Radiographic evaluation after reduction must be carried out and improper reduction is found in a certain number. To find a better guide by normal surgical landmark the study was carried out as a survey research in 600 volunteers aged from 10 to 70 years. Simple caliper and tape were used to measure the height, foot length and inter anterior superior iliac spine distance. In 376/420 male volunteers (89%), the length between right heel and tip of the fourth toe was equal to the inter anterior superior iliac spine distance. In 173/180 female volunteers (96%), the length between right heel and tip of big toe was equal to the inter anterior superior iliac spine distance. The length of the right foot can be used as a reference in reducing unstable fractured pelvis by external fixation. These data were used in the management of 36 patients with unstable fractured pelvis with external fixation for reduction and stabilization. All had good results.

Adolescent↗

PubMed1998

Vascular injuries in compound fractures of the leg with initially adequate circulation.

We carried out a randomised, controlled trial in 157 patients who had isolated severe Gustilo type-IIIa and type-IIIb fractures of the metaphysis or diaphysis of the leg to determine the prevalence of vascular injuries and the role of vascular repair. All patients had stable vital signs and clinically adequate circulation in their legs before operation. In a control group of 64 patients we performed conventional surgery with systematic debridement and primary stabilisation of the fractures. In the trial group of 93 patients the major vessels and nerves adjoining the compound fracture were routinely explored and repaired when necessary after the initial procedure. Two of the 28 control patients (7.1%) with type-IIIb compound fractures had signs of inadequate circulation after the first operation. Both had major vascular injuries which were demonstrated at a second procedure. In the trial group, major vascular injuries were found in two of 54 patients (3.7%) with type-IIIa and 11 of 39 patients (28.2%) with type-IIIb compound fractures. Compared with the control group the trial group showed improved results at both the immediate and long-term follow-up. Routine exploration and early repair of injured major vessels of the leg in severe compound fractures gave encouraging results.

Adolescent↗

PubMed1998

Prognostic factors for major limb re-implantation at both immediate and long-term follow-up.

We performed a prospective study in 186 patients with a minimum follow-up of two years in order to attempt to predict successful major re-implantation of the upper limb. There were 137 men and 49 women with 24 amputations of the palm, 75 of the wrist, 50 of the forearm, 9 disarticulations through the elbow, and 28 amputations through the upper arm. The degree of injury to the amputated segment and the stump were good predictors of the rate of success and the final outcome. Adequate preservation, contraction of the muscle in the amputated part after stimulation, the level of injury and a smoking habit were fair indicators, but the serum potassium concentration in the amputated segment was the best objective predictor. When it is higher than 6.5 mmol/l 30 minutes after re-perfusion, re-implantation should be avoided. A high systemic venous serum potassium concentration was also found before clinical signs of the re-perfusion syndrome were seen.

Adult↗

PubMed1997

Revascularization of degloving injuries of the limbs.

Between 1990 and 1994 a study was carried out of 32 patients who had degloving injuries of the limbs. There were three types of injuries: type I, nine patients with severely damaged skin and subcutaneous tissue; type II, 13 patients whose skin and subcutaneous tissue were moderately damaged, but subcutaneous veins were still identifiable; and type III, 10 patients whose skin and subcutaneous tissue were moderately damaged and venous back flow was observed. The patients in type I were treated by extensive debridement and the flaps were used for free full and split thickness skin grafting. In type II, arterialization of the venous system of the flaps was performed and successful perfusion was observed in nine patients. In type III, venous anastomoses were performed and all had good results. Revascularization of the flaps in types II and III degloving injuries of the limbs gave good results. The raw surface which needed skin grafting was minimized and the course of treatment and morbidity were decreased.

Adolescent↗