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Biomedical subjects

S Wallin

Publications and source records attributed to S Wallin.

10 recordsLinked to original sources

Three-helix-bundle protein in a Ramachandran model.

We study the thermodynamic behavior of a model protein with 54 amino acids that forms a three-helix bundle in its native state. The model contains three types of amino acids and five to six atoms per amino acid and has the Ramachandran torsional angles phi(i), psi(i) as its degrees of freedom. The force field is based on hydrogen bonds and effective hydrophobicity forces. For a suitable choice of the relative strength of these interactions, we find that the three-helix-bundle protein undergoes an abrupt folding transition from an expanded state to the native state. Also shown is that the corresponding one- and two-helix segments are less stable than the three-helix sequence.

Models, Molecular↗

A conflict of strategies: Medicaid managed care and Medicaid maximization.

OBJECTIVE: To examine the influence of state strategies aimed at increasing federal Medicaid matching dollars on the design of states' Medicaid managed care programs. STUDY DESIGN: Data obtained from the 1996-1997 case studies of 13 states to examine how states have adapted the design of their Medicaid managed care programs in part because of maximization strategies, to accommodate the many roles and responsibilities that Medicaid has assumed over the years. PRINCIPAL FINDINGS: Our study showed that as states made the shift to managed care, some found that the responsibilities undertaken in part through maximization strategies proved to be in conflict with their Medicaid managed care initiatives. Among other things, the study revealed that most states included provisions that preserved the health care safety net, such as adapting the managed care benefit package and promoting the participation of safety net providers in managed care programs. In addition, most of the study states continued to pay special subsidies to safety net providers, including hospitals and clinics. CONCLUSIONS: States have made real progress in moving a large number of Medicaid beneficiaries into managed care. At the same time, many states have specially crafted their managed care programs to accommodate safety net providers and existing funding mechanisms. By making these adaptations states, in the long run, may compromise the central goals of managed care: controlling costs and improving Medicaid beneficiaries' access to and quality of care.

Economics, Hospital↗

On the Singlet Spectrum of ZrS.

Three electronic transitions in the singlet manifold of the zirconium sulphide (ZrS) molecule have been rotationally analyzed. They are the B1Pi-X1Sigma+, C1Sigma+-X1Sigma+, and E1Sigma+-X1Sigma+ systems with (0,0) band heads at 924.60, 731.51, and 494.47 nm, respectively. The ground state X1Sigma+ has an equilibrium bond distance of 2.15661(4) Å. Perturbations in the B1Pi and C1Sigma+ states are discussed. Copyright 1998 Academic Press.

Journal Article↗

High-Resolution Spectroscopy of TaS in the Visible and Near-Infrared Regions.

The spectrum of TaS between 4000 and 20 000 cm-1 has been recorded in emission from a microwave discharge with a resolution between 0.011 and 0.025 cm-1. Seventeen electronic transitions have been rotationally analyzed. Fifteen of these have the ground state, 2Delta, as the lower state and two of them are transitions between excited states. The ground state has been fitted to a Hund's case (a) Hamiltonian. Effective molecular constants have been determined for the excited states, which are mainly described as Hund's case (c). Perturbations that have been found in the excited states are discussed. Transitions between states that are connected neither to the ground state nor to any of the other 14 electronic states of this work have been found. No analysis is presented for these transitions, but some of their characteristic features are described. Copyright 1998 Academic Press.

Journal Article↗

Lipid peroxidation and activities of tyrosine aminotransferase and glutamine synthetase in hepatoma and glioma cells grown in bovine colostrum-supplemented medium.

The growth stimulating properties of bovine serum and colostrum were compared in rat hepatoma (HTC) and glioma (C6) cell cultures. A colostrum concentration of 2% was optimal for HTC cells, which then reached a terminal density 40% of that in serum-supplemented medium. The corresponding figures for C6 cells were 10 and 81%, respectively. After 4 d in culture, levels of lipid hydroperoxides were measured and compared. Highest levels of lipid hydroperoxides were found in HTC and C6 cells grown in unsupplemented medium. HTC and C6 cells grown in serum supplemented medium contained levels of 52 and 64%, respectively, of that in unsupplemented medium. The corresponding levels for cells grown in presence of colostrum were 40% for HTC and 44% for C6 cells. To obtain information on any functional alterations in the cells due to the presence of colostrum the induction of tyrosine aminotransferase (EC 2.6.1.5) and glutamine synthetase (EC 6.3.1.2) by dexamethasone was studied. Although colostrum seemed to increase the basal activities of the enzymes, no significant effects on the degree of induction could be detected.

Animals↗