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Biomedical subjects

S Weill

Publications and source records attributed to S Weill.

18 recordsLinked to original sources
PubMed1989

Ciliary ultrastructure of respiratory and fallopian tube epithelium in a sterile woman with Kartagener's syndrome. A quantitative estimation.

Ciliary ultrastructure was studied and quantitatively estimated in a 27-year-old sterile woman suffering from complete KS. Ciliated epithelium was obtained from both nasal mucosa and a fallopian tube. Cilia from both locations were devoid of DA. Various MT abnormalities were found in 16 percent of respiratory epithelial and 21 percent of fallopian tube ciliary cross-sections. The abnormality related to radial spoke defect was frequently seen. The findings in the fallopian tubes were compared to three normal control cases. In these, DA were visible, and MT defects were mainly of excess or missing microtubules. The relevance of these findings to fertility is not clear.

Adult↗
PubMed1988

The pattern of epithelial mucin secretion in normal, hyperplastic, and adenocarcinomatous endometrium.

Stains for mucosubstances were performed on endometrial curetting material of normal and pathological endometrium. The study included normal proliferative and secretory endometrium, cystic and adenomatous hyperplasia, and endometrial adenocarcinoma. It was attempted to characterize the epithelial mucin in each of these conditions and to differentiate between them. The stains used were Alcian blue at pH 0.5 and 2.5; PAS with and without diastase digestion; and Toluidine blue. It was concluded that the Alcian blue stain at pH 2.5 was preferable for differentiating two groups: group one included benign conditions--normal endometrium, cystic hyperplasia, and adenomatous hyperplasia without atypia--in which the cytoplasm did not show any staining reaction. Group two included premalignant and malignant conditions, namely adenomatous hyperplasia with severe atypia and endometrial adenocarcinoma. In these conditions, definite staining of the cytoplasm was visible with Alcian blue at pH 2.5. The difference was statistically significant. In addition, strongly positive staining of the apical border was noted in both groups. Alcian blue at pH 0.5, PAS stain, and Toluidine blue were of no aid in differentiating the two groups. PAS stain resulted in positive apical and cytoplasmic staining in a large percentage of cases of all the different conditions. Toluidine blue did not show consistent staining of the cells. It was deduced that the cytoplasm of the premalignant and malignant group contained sulphated and nonsulphated acid mucopolysaccharides, as opposed to the benign conditions, in which the cytoplasm contained neutral mucopolysaccharides and glycogen. In each of the conditions acid and neutral mucopolysaccharides were present at the apical border. The finding of stainable cytoplasmic mucosubstances in endometrial adenocarcinoma is in contrast to what has been generally reported that such mucosubstances were characteristic of adenocarcinoma of endocervical origin only. Our study enabled us to differentiate endometrial adenomatous hyperplasia with severe atypia and adenocarcinoma from the more benign conditions by staining of cytoplasmic mucin with Alcian blue at pH 2.5.

Adenocarcinoma↗
PubMed1988

Stage III-IV epithelial carcinoma of the ovary: is the second-look operation of any value for the patient?

A second-look operation (SLO) was performed in 18 of 24 patients operated for Stage III-IV epithelial carcinoma of the ovary in order to assess the effect of chemotherapy and to decide if further treatment, such as radiation therapy, was indicated. All patients had postoperative combination chemotherapy: either with PA [Platinol (Bristol, UK) and adriamycin] or with CHAD (cyclophosphamide, hexamethylmelamine, adriamycin and cis-diamminedichloroplatinum). In 7 of 18 (39%) patients who had SLO following chemotherapy, macroscopic tumor was present; in 7 (39%) patients, microscopic residual or recurrent disease was found, as proven by histological examination of the biopsies taken during the operation. Only in four patients (29.7%) was the SLO negative. Of these patients, three had recurrent disease after 3,6 and 7 months postoperatively. These findings indicate that the SLO was noncontributory to the management of the patients. The role of the SLO commonly used in most current treatment protocols of patients with Stage III-IV epithelial carcinoma of the ovary is questionable and requires further evaluation.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1987

Outpatient diagnostic endometrial aspiration curettage with a new aspiration curette.

During a period of 2 years (1981-1982), 226 outpatient endometrial aspiration curettages (EACs) were performed with a new aspiration curette that had been developed by the authors. All patients had risk for general anesthesia. From 17 of them, endometrial polyps were removed by the EAC. Endometrial carcinoma was diagnosed in eight others, adenomatous hyperplasia in four, and cystic hyperplasia in two women. The main advantage of the new curette is the ability to aspirate endometrial polyps through its modified opening.

Adolescent↗
PubMed1985

Leydig-cell tumor of the ovary: visualization using 131I-19-iodocholesterol scintigraphy.

A Leydig (Hilus)-cell tumor of the ovary was diagnosed in a 54-year-old woman with severe hirsutism and virilization. This case is unique in that it was diagnosed in a postmenopausal female 24 years after ovarian irradiation for sterilization, and the tumor was successfully localized preoperatively using 131I-19-iodocholesterol scintigraphy. This nuclear scanning technique may be of use in documenting the biologic activity of ovarian masses and in localizing functioning ovarian tumors which are too small to palpate or to localize by other means.

19-Iodocholesterol↗
PubMed1985

Giant chorioangioma of the placenta.

We report a case of giant chorioangioma of the placenta which was complicated by breech presentation, placenta praevia, hydramnios, toxemia and premature separation of the placenta. These complications are described separately in the literature as being associated with chorioangioma of the placenta, but rarely appear together in a single case.

Adult↗
PubMed1977

[Indications for hysterectomy in placental tumors].

Indications for hysterectomy in placental tumours are now most often to carry out hysterectomy as a second attack designed to deal with residual lesions of choriocarcinoma that prove resistant to chemotherapy. Of 80 patients treated, 24 were first seen for chemotherapy after hysterectomy and this is too great a number. On the remaining 56 patients we carried out hysterectomy in 8 cases of whom 7 were secondary to chemotherapy. Seven times we found a residual lesion. These patients are now apparently cured.

Adult↗
PubMedDate not supplied

The reproductive system of male rats exposed to very low doses of ionizing radiation, 1: Hormonal profile of animals exposed after sexual maturity.

Adult male rats were treated with a single, whole body exposure to a dose of 0.001, 0.01 or 0.1 Gy (1 Gy = 100 rad). The animals were sacrificed 1, 7, 30, 100 or 180 days following exposure. Serum testosterone, serum and hypophyseal LH, FSH and prolactin as well as hypothalamic LHRH were measured. In the 0.1 Gy irradiated rats, serum LH and FSH were 100% higher and serum prolactin was 30% lower as compared to controls, 30 days after irradiation. The concentrations of these hormones remained significantly different from control values even after 180 days after exposure. On the other hand, the hypophyseal content of LH, FSH and prolactin decreased in the 0.1 Gy treated rats, 100 days after irradiation. In the group of the 0.01 Gy irradiated rats, serum FSH increased by 70% and hypophyseal FSH decreased. No changes were observed in serum testosterone and hypothalamic LHRH in any of the irradiated groups and no changes were observed in the group exposed to 0.001 Gy. It may be concluded that a long term damage to the reproductive system of the male rat was induced by a single, whole body exposure to 0.1 Gy of gamma radiation.

Animals↗