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Biomedical subjects

S Weitzner

Publications and source records attributed to S Weitzner.

At least 37 records · Page 2Linked to original sources
PubMed1979

Intramammary granular cell myoblastoma.

Two female patients, age 15 and 21 years, with intramammary granular cell myoblastoma who were without recurrence of the development of additional lesions after one year and eight years, nine months respectively, are reported. Electron microscopic examination of one of our cases disclosed the typical osomphilic granules but no features to support a particular cell of origin. Review of the 52 previously reported cases indicates that this unusual intramammary neoplasm has been encountered with relatively few exceptions in the 20 to 59 year age group and in the upper quadrants. It clinically mimics fibroadenoma or carcinoma and on frozen section examination may be misinterpreted as malignant. None have recurred following adequate excision.

Adenofibroma↗
PubMed1978

Acute megakaryocytic leukemia. Description of a case initially seen as preleukemia syndrome.

A 52-year-old man had aregenerative anemia unresponsive to pyridoxine hydrochloride. Acute leukemia developed, and he died four months after diagnosis. At autopsy he had acute megakaryocytic leukemia with involvement of bone marrow, liver, spleen, adrenals, kidneys, and thyroid. Chromosomal analysis revealed absence of both diploid and Ph1 chromosomes. A mode of 45 chromosomes and aneuploidy were present. This is similar to the only other case with chromosomal studies. Of the 15 acceptable documented cases, eight were men and seven were women. Their age varied from 28 to 76 (mean, 55) years. Only two were less than 40 years of age. Most had pancytopenia, and all were dead within six months of diagnosis.

Autopsy↗
PubMed1978

Kaposi's sarcoma in renal allograft recipients.

The development of Kaposi's sarcoma in immunosuppressed patients is a rare occurrence, but poses a real threat to the patient due to the rapid progression of the unchecked disease. The suspicion of this disease will prompt early diagnosis by scrutiny of histologic preparations and prompt interruption of antirejection therapy. Four of five patients in whom a diagnosis was made preterminally responded favorably to withdrawal of immunosuppressive agents. In renal allograft recipients with mucocutaneous vascular lesions, Kaposi's sarcoma should be considered as a cause of gastrointestinal bleeding.

Adult↗
PubMed1978

Leiomyosarcoma of urinary bladder in children.

A case of leiomyosarcoma of the bladder is reported in a fourteen-year-old girl who is alive and without evidence of disease two years after partial cystectomy. Electron microscopy confirmed its smooth muscle nature. The data for 7 other children, including follow-up for 5, are tabulated. Partial cystectomy with adequate margin appears to be the treatment of choice when feasible. The tumor may be controlled with chemotherapy and radiation therapy in unresectable cases.

Adolescent↗
PubMed1978

Adenoacanthoma of the pancreas: report of four cases and literature review.

Cases of 20 patients with adenoacenthoma of the pancreas with clinicopathologic data, including the four added, are reviewed. The clinical manifestations, sites of metastases, survival and gross pathology appear to be similar to the usual adenocarcinoma of the pancreas. Adenoacanthoma of the pancreas most probably represents squamous metaplasia of an adenocarcinoma or arises from an undifferentiated cell in the pancreatic duct system. The metastases are typically an admixture of both elements but in four cases, pure squamous or adenocarcinoma metastases were encountered. It is suggested that the pancreas should be included as a possible source in those patients with an unknown primary who have a metastasis consisting of either an admixture of squamous and glandular elements or a pure squamous type and in those instances in which a pure squamous and a pure adenocarcinoma are encountered in different metastases.

Adenocarcinoma↗
PubMed1976

Primary reticulum cell sarcoma of testis in a 12-year-old.

A 12-year-old boy with primary reticulum cell sarcoma of the testis who is alive and free of tumor 32 months after orchiectomy, radiation therapy to inguinal, iliac and retroperitoneal lymph nodes and chemotherapy is reported. Seven previously documented cases of childhood primary testicular lymphoma are reviewed. The patient with reticulum cell and one with lymphosarcoma were alive and tumor-free 4 and 18 months respectively. The other 5 with primary testicular lymphosarcoma died. Four survived for periods up to 1 year, 3 developing generalized lymphosarcoma and 1 leukemia. The fifth was tumor-free for 4 years and developed leukemia 2 weeks before death. The small number of cases precludes evaluation of survival in relation to various modes of therapy. Primary lymphoma of testis, no evidence of lymphoma elsewhere at time of orchiectomy, does exist. Its relatively benign biologic behavior in some remains an enigma.

Child↗
PubMed1976

Spermatocytic seminoma.

A case is reported of a forty-four-year-old man with spermatocytic seminoma with no evidence of metastasis for twelve years. This patient is the second to have undergone retroperitoneal lymph node dissection and the third to have histopathologic examination of these lymph nodes. Review of 52 cases of spermatocytic seminoma disclosed 70 per cent of patients were over fifty years of age; none developed in a cryptorchid testis, none occurred in associated with teratoma, and there was no histopathologic evidence of metastasis. Whether or not radiation therapy is necessary is questionalbe. Prognosis appears to be good if not better than in classic seminoma. Available data indicate that spermatocytic and classic seminoma are two distinct neoplasms with different histogenesis and pathologic, clinical, and biologic features.

Adult↗
PubMed1976

Primary carcinoid of testis.

A patient with primary solid carcinoid of the testis is described and 8 previous cases are reviewed. Ultrastructural study of our case disclosed pleomorphic granules, typical of the insular type carcinoid of the intestine of midgut derivation. Primary solid testicular carcinoid appears to behave as a benign neoplasms. None of these patients had evidence of metastases or the carcinoid syndrome for periods ranging from 20 months to 25 years.

Carcinoid Tumor↗
PubMed1976

Leiomyosarcoma of the inferior vena cava: report of a case and review of the literature.

Leiomyosarcoma of the inferior vena cava is a rare and usually fatal disease. Only 45 cases have been reported in the world literature. The authors add one case and review all previous reports. The disease is one primarily of elderly women, arising from the middle third of the inferior vena cava with a wide range of symptomatology, varying form the Budd-Chiari syndrome to a few asymptomatic cases. The tumor may grow very slowly or occasionally very rapidly, shows extensive local invasion, and metastasizes more frequently than previously believed. While radiotherapy and chemotherapy have not been adequately studied, aggresive surgical intervention using the recent advances in vascular surgery appears to offer long term palliation and hopefully cures of this disease in the future.

Aged↗
PubMed1976

Blue nevus of the hard palate.

The occurrence of a blue nevus of the hard palate in a 72-year-old man is reported. Of the 25 previously documented cases of blue nevus of the oral cavity, 19 were on the hard palate, three on the upper lip, and one each on the lower lip, buccal mucosa, and soft palate. Fourteen were in women and 11 were in men. All but five patients were younger than 50 years of age. The size of the asymptomatic, flat to somewhat elevated, blue-black lesion varied up to 5 mm except for one that was 10 mm in the greatest dimension. Most nevi were of unknown duration and were found incidentally during dental examination. The histogenesis of extracutaneous blue nevus is undetermined but derivation from melanogenic potential of Schwann or endoneurial cells or from stimulation of retained melanoblasts in the stroma developing into melanocytes and formation of blue nevus is possible.

Aged↗
PubMed1976

Adjacent malignant schwannoma and neurofibroma of intrathoracic vagus.

A 24-year-old man with neurofibromatosis and adjacent malignant schwannoma and neurofibroma of an intrathoracic vagus is reported. He survived for eight months, developing massive recurrence three months after surgical extirpation. Review of the 13 previously documented patients with neurofibroma of the intrathoracic vagus indicates that most patients have neurofibromatosis. The thickest portion of the intrathoracic vagi, the proximal portions and most often the left nerve, is the site of predilection. In about half, multiple neurofibromata of the nerve may be present. Malignant schwannoma of the mediastinum is discussed and it would appear that neurofibromatosis is not a predisposing factor.

Adult↗
PubMed1975

Hemangiosarcoma of spleen with spontaneous rupture.

A 76-year-old man with spontaneous rupture of a hemangiosarcoma of the spleen, together with a review of 49 previously reported patients with splenic hemangiosarcoma are presented. Twenty-three were women and 27 were men. All but 3 were adults. Fiften were 50-59 years of age. The symptomatology was nonspecific. Three patients developed microangiopathic hemolytic anemia. Spontaneous rupture occurred in 17 cases (34%). Metastases occurred in 42 cases; they were primarily hematogenous and most often in the liver. Lymph node involvement, however, was present in 13 cases. The prognosis of untreated splenic hemangiosarcoma is poor. Three of 25 patients survived a year or more after the initial onset of symptoms. Splenectomy before rupture is advisable, since 5 of 19 patients survived at least 1-5 years. It is suggested that hemangiosarcoma be considered in patients with: 1) splenomegaly without evidence of malignant lymphoma or leukemia, 2) splenomegaly with microangiopathic hemolytic anemia, and 3) unexplained intraperitoneal hemorrhage.

Adolescent↗
PubMed1975

Adenoid cystic carcinoma of submaxillary gland metastatic to great toe.

A case of adenoid cystic carcinoma of the submaxillary gland metastatic to the left great toe in a 52-year-old man is reported. The patient survived 10 months after diagnosis of the metastasis to the hallux. The well-documented cases of four other patients, two each with pulmonary and renal-cell carcinoma metastatic to the toe, are reviewed. Metastatic carcinoma to the toe as well as the finger typically mimics an inflammatory process. An osteolytic lesion of the phalanx of a toe or finger resembling an inflammatory process without a history of injury or infection should suggest the possibility of malignancy.

Bone Neoplasms↗