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Biomedical subjects

S Wetzel

Publications and source records attributed to S Wetzel.

26 records · Page 2Linked to original sources
PubMed1994

Paroxetine in the treatment of inpatients with non-delusional endogenous or neurotic depression.

The clinical course of 35 depressed inpatients (19 women, 16 men; 19 endogenous, 16 neurotic depression (ICD-9 diagnoses); mean age 46.7 years) who were treated with paroxetine 20 mg/d was observed over 21 days using the Hamilton Depression Scale (HAMD). For both types of depression there was a significant decrease from day 1 to day 21 in the mean HAMD total score and in a subscore of cognitive and somatic items. The mean value of the HAMD suicide item increased in 3 cases and decreased in 25.

Adult↗
PubMed1993

Teat tissue reactions to milking: effects of vacuum level.

Machine-induced changes in diameter, thickness, and compressibility of the teat apex and teat barrel were measured on all teats of four cows milked at vacuums of 25, 30, 40, and 50 kPa. Measurements were made with an electronic caliper instrument immediately before milking and then at .5, 15, and 30 min after milking. Teat length was also measured at these times. Immediately after milking, for the two higher levels, teats were significantly thicker (7 to 10% thicker at 40 kPa, 17 to 25% at 50 kPa), shorter (by 3 to 6 mm), smaller in diameter (by 2 to 4 mm for the apex, 3 to 6 mm for the barrel), and less compressible for all milking treatments compared with the premilking status for individual teats. Although teat thickness recovered to the premilking mean values 30 min after milking at 40 or 50 kPa, the barrel still was significantly thicker after 30 min compared with those at the lower vacuum treatments. We suggest that changes in teat length, diameter, thickness, and compressibility after milking at low vacuum levels mainly reflect tissue responses to udder evacuation. In contrast, increased teat wall thickness and reduced compressibility of teat tissue at higher vacuum levels likely result mainly from machine-induced edema.

Animals↗
PubMed1991

The 32-Kilodalton Vegetative Storage Protein of Salix microstachya Turz : Characterization and Immunolocalization.

A 32-kilodalton vegetative storage protein, found in Salix microstachya Turz. bark during the overwintering period, was purified and characterized using several polyacrylamide gel electrophoretic procedures. Solubility characteristics and amino acid analyses were also performed. The protein is water soluble, is glycosylated, has no disulfide-bonded subunits, but is composed of a family of isoelectric isomers. The majority of these isomers are basic. Characteristic of storage proteins, the protein is rich in glutamine/glutamate and asparagine/aspartate (28%), the basic nature of the isomers indicating that most of these amino acid residues are in the amide form. The protein was purified using preparative sodium dodecyl sulfate-polyacrylamide gel electrophoresis and antibodies raised in chickens. Immunoblot analysis suggested an annual cyclic nature of the accumulation and mobilization of this vegetative storage protein. Immunologically, it is related to a similar molecular weight protein found in the bark of Populus deltoides Marsh. but not to any overwintering storage proteins of the other hardwoods tested. Indirect immunolocalization revealed that the protein was sequestered in protein-storage vacuoles in parenchymatous cells of the inner bark tissues of Salix during the winter months.

Journal Article↗
PubMed1989

Hyperthyroid adult rat cardiomyocytes. I. Nucleotide content, beta- and alpha-adrenoreceptors, and cAMP production.

Ventricular myocytes isolated from the hypertrophied hearts of thyrotoxic adult rats have an increase in mean protein content per myocyte (6.3 +/- 0.2 vs. 4.4 +/- 0.2 ng) compared with euthyroid cells. Viability and adenine nucleotide profiles are similar in both populations, but NAD content of the hyperthyroid myocytes is depressed (4.9 +/- 0.2 vs. 5.5 +/- 0.2 nmol/mg for controls) and UTP is higher (1.2 +/- 0.09 vs. 0.9 +/- 0.04 nmol/mg). Binding of (-)-[125I]iodocyanopindolol to intact hyperthyroid myocytes is increased by 42% compared with controls, with no change in the dissociation constant (Kd). This elevation in beta-receptor number is correlated to enhanced beta-agonist-induced adenosine 3',5'-cyclic monophosphate (cAMP) production. The half-maximal effective concentration (EC50) for the euthyroid isoproterenol dose-response curve is 2.14 x 10(-7) M but is decreased to 2.51 x 10(-8) M in hyperthyroid cardiac cells. Basal adenylate cyclase activity is apparently not affected by thyroid hormones, since basal cAMP levels for both groups are identical (5 pmol/mg) and both rise roughly twofold in the presence of a phosphodiesterase inhibitor. Forskolin-induced cAMP production and cAMP-specific phosphodiesterase activity are similar as well. In contrast to beta-adrenergic response, there are no significant differences in alpha 1-antagonist [3H]prazosin binding parameters between hyperthyroid and euthyroid cardiomyocytes.

1-Methyl-3-isobutylxanthine↗
PubMed1988

The effect of low dietary calcium and calcium supplementation on calcium metabolism and bone in the immature, growing rat.

The data presented here were obtained from a series of experiments designed to determine 1) whether normal growth and bone development could be maintained in young, growing rats (3-9 weeks of age) on a diet containing 0.1% Ca, and 2) whether Ca presented in a bolus would be utilized as effectively as the same amount of Ca distributed throughout the diet. Weanling female rats were raised to 9 weeks of age on diets containing 0.4% P and either 0.5% or 0.1% Ca. One group of animals on the 0.1% Ca diet was given oral supplements of CaCO3 twice each day to supply the same amount of Ca consumed by age-matched animals on the 0.5% Ca diet. We found that animals consuming diet containing 0.1% Ca grew at the same rate as animals receiving 0.5% Ca, or 0.1% Ca + supplement for up to 9 weeks of age when the experiment was terminated. Measurement of femur length indicated that long bone length was the same for all animals. However, the 0.1% Ca group exhibited mild hypocalcemia (9.1 mg/dl vs 10.4 for controls), a 2.6-fold elevation in immunoreactive parathyroid hormone, and an increase of similar magnitude in circulating levels of 1,25-dihydroxyvitamin D. Bones from the 0.1% Ca group contained less than half as much Ca as bones from the 0.5% Ca group, and exhibited significant decreases in mid-shaft diaphyseal thickness, % trabecular volume of the distal metaphysis and breaking strength (torsion testing). These results suggest that while a diet containing 0.1% Ca is able to maintain normal growth, bone mineralization is compromised.(ABSTRACT TRUNCATED AT 250 WORDS)

Aging↗
PubMed1978

[Diagnostic and therapeutic aspects of early (superficial) gastric carcinoma: a retrospective analysis of 60 cases (author's transl)].

Among 947 patients operated on for gastric carcinoma between 1961 and 1976 there were 60 with early (superficial) gastric carcinoma. All but two patients consulted their doctor for diverse complaints. In one third of them treatment was delayed for a year or longer. In 26 of the 64 cancer foci it was limited to the mucosa. The correct diagnosis was made radiologically in 60%, gastroscopically in 70%. Selective endoscopic biopsy increased accuracy to 90%. The remaining false-negative findings occurred in the ulcerative form, which was the most frequent one. Improved radiological techniques (double-contrast) and obligatory gastroscopy with biopsy increased the relative proportion of early (superficial) carcinoma from under 4% in 1961 to 15%. The diagnosis of this type of carcinoma can be made only by careful histological study of the surgical specimens. Here as elsewhere in the surgery of carcinoma, multicentricity (in 5%) and possible lymph node metastases (10-20%) must be taken consideration in the surgical management.

Adult↗