Biomedical subjects
Publications and source records attributed to S Wiemers.
Porocarcinoma is a very rare malignant tumor arising from the duct of eccrine sweat glands. Its prognosis is variable. We report on a patient who developed lymph node and multiple distant metastases, and who died of this malignancy only 6 months after the initial diagnosis.
Subungual keratoacanthomas (SKA) differ in clinical presentation, biological behaviour and the therapy needed from keratoacanthomas in other localizations. Against the backdrop of two personal observations and a review of the literature, the authors describe clinical and histological features and also the differential diagnosis and therapy and this rare benign neoplasm. Patients present with a rapidly growing, painful subungual mass, which causes destruction of the underlying bone and usually does not regress spontaneously. Histological differentiation from squamous cell carcinoma is essential as the prognosis and treatment are different. SKA is treated by local excision and curettage. Erosions of the underlying distal phalanx usually heal spontaneously. However, persistent recurrences after subtotal excision often necessitate amputation of the distal phalanx.
Herpes simplex virus (HSV) infection is a well-known trigger mechanism for both erythema multiforme (EM) and psoriasis. While HSV-related EM and psoriasis are not uncommon, simultaneous development of both disorders following HSV infection is relatively rare. We report on a patient who simultaneously developed both EM and a guttate psoriasis within 16 days of an HSV infection. The major differences in the pathophysiological mechanisms by which these dermatoses are triggered are discussed.