PubMed Health⌕ Search

Biomedical subjects

S Winblad

Publications and source records attributed to S Winblad.

At least 19 recordsLinked to original sources
PubMed2006

Facial emotion recognition in myotonic dystrophy type 1 correlates with CTG repeat expansion.

OBJECTIVE: To investigate the ability of patients with myotonic dystrophy type 1 to recognise basic facial emotions. We also explored the relationship between facial emotion recognition, neuropsychological data, personality, and CTG repeat expansion data in the DM-1 group. METHODS: In total, 50 patients with DM-1 (28 women and 22 men) participated, with 41 healthy controls. Recognition of facial emotional expressions was assessed using photographs of basic emotions. A set of tests measured cognition and personality dimensions, and CTG repeat size was quantified in blood lymphocytes. RESULTS: Patients with DM-1 showed impaired recognition of facial emotions compared with controls. A significant negative correlation was found between total score of emotion recognition in a forced choice task and CTG repeat size. Furthermore, specific cognitive functions (vocabulary, visuospatial construction ability, and speed) and personality dimensions (reward dependence and cooperativeness) correlated with scores on the forced choice emotion recognition task. CONCLUSION: These findings revealed a CTG repeat dependent facial emotion recognition deficit in the DM-1 group, which was associated with specific neuropsychological functions. Furthermore, a correlation was found between facial emotional recognition ability and personality dimensions associated with sociability. This adds a new clinically relevant dimension in the cognitive deficits associated with DM-1.

Adult↗
PubMed2005

Temperament and character in patients with classical myotonic dystrophy type 1 (DM-1).

This study was designed to investigate personality in classical Myotonic Dystrophy (DM-1). Forty-six patients with DM-1 (25 women and 21 men), 31 healthy controls and 37 subjects in a contrast group, consisting of patients with other muscle disorders (spinal muscular atrophy, facioscapulohumeral dystrophy and limb girdle muscular dystrophy), completed the Temperament and Character Inventory (TCI) (Cloninger, 1994). We aimed to establish whether CTG triplet repeat size correlated with ratings of personality dimensions in the TCI. The DM-1 patients scored significantly higher on the TCI dimension Harm avoidance and lower on Persistence, Self-directedness and Cooperativeness. Signs of a personality disorder were found in 20% of the DM-1 patients. No correlation was found between the number of CTG repeats and scores in the TCI. This study indicates deviant personality in classical DM-1 regarding temperament and character, both in comparison to healthy controls and to patients with other muscle disorders with no known brain disorder.

Adolescent↗
PubMed1986

Yersinia enterocolitica associated with third trimester abortion in buffaloes.

A group of buffaloes aborted at the third trimester of their gestational period. Yersinia enterocolitica was isolated from all cases. All aborted animal sera had high antibody titres against Y. enterocolitica antigen which crossreacted significantly with Brucella abortus antigen. All animals were culturally negative after intrauterine infusion of gentamycin sulphate (160 mg/day) for three consecutive days.

Abortion, Veterinary↗
PubMed1983

Demonstration of a saturable binding site for thyrotropin in Yersinia enterocolitica.

Several lines of evidence suggest that there might be immunologic cross-reactivity between the thyroid plasma membrane in humans and antigenic determinants in the enteric pathogen Yersinia enterocolitica. Studies were therefore performed to determine whether Y. enterocolitica, like the thyroid membrane, contains a thyrotropin binding site. A saturable binding site for bovine thyrotropin was indeed demonstrable, particularly in preparations of the organism that have been treated with ethylenediaminetetraacetate and lysozyme. Hormonal specificity of the binding site, as judged from the inhibition of binding of 125I-labeled bovine thyrotropin, was similar to that of the thyrotropin receptor in human thyroid tissue.

Binding Sites↗
PubMed1981

Yersinia enterocolitica arthritis in southern Sweden: a four-year follow-up study.

Thirty-eight cases of suspected yersinia arthritis occurring in southern Sweden in 1975-6 were reviewed four to five years later. In 31 cases the diagnosis was confirmed. At follow-up three of the patients had definite ankylosing spondylitis, three radiologically confirmed sacroiliitis, three extensor tenosynovitis, five isolated articular joint disease, and 10 localised arthralgias; one patient had developed seropositive rheumatoid arthritis. Only six of the 31 patients were free of joint symptoms. These results suggest that although the acute symptoms of yersinia arthritis disappear within 12 months, the long-term prognosis may be less favourable than previously thought.

Acute Disease↗
PubMed1981

Glomerulonephritis in infections with Yersinia enterocolitica O-serotype 3. I. Evidence for glomerular involvement in acute cases of yersiniosis.

Signs of damage to the glomerular basement membrane appearing as haematuria and proteinuria have been observed in 16 cases of proven acute yersiniosis. The infecting agent was Yersinia enterocolitica serotype O:3 in all. In a few cases a transient deterioration of the renal function was observed. The renal symptoms were not related to the acute febrile state, but seemed to appear about 14 days after the onset of yersiniosis and to be reversible in the observation period. Infection with other microorganisms known as nephritogenic was not found in spite of attempts to do so. Kidney biopsy was performed in one case and immunofluorescence microscopy showed deposits of immunoreactants. Based on these observations we suggest that acute glomerulonephritis can be included in the spectrum of complications of infection with Yersinia enterocolitica serotype O:3. The frequency of complicating glomerulonephritis in yersiniosis could not be estimated from this study.

Adolescent↗
PubMed1979

Studies on Yersinia enterocolitica isolated from swine and dogs.

Yersinia enterocolitica serotype 03 was isolated from the colon contents of 27 (4.5%) of 599 bacon pigs on slaughter. Two (1.7%) out of 115 dogs were positive by culture for this human-athogenic serotype of Y. enterocolitica. A number of other serotypes of Y. enterocolitica were also obtained both from porcine and canine enteric contents (4b, 5a, 6, 7, 11, 12, 15, 17, 19, 26b, and non-typeable strains). All these serotypes are supposedly non-pathogenic for man and may possibly originate from the microflora of the environment. Haemolysis on bovine blood agar was observed for strains belonging to O-serotype 3.

Animals↗
PubMed1979

Studies on the interaction between different O-serotypes of Yersinia enterocolitica and HeLa cells.

Eighty strains of Yersinia enterocolitica were examined for their ability to invade HeLa cells. The following O-serotypes were found to be invasive: 1, 3, 4a, 4c, 5b, 8, 9, 15a, 18, 20, 21 and 22. Biochemically, these types are either indole-, aesculin-, and salicin-negative, or indole-positive but aesculin- and salicin-negative. Other serotypes of Y. enterocolitica did not invade HeLa cells. Biochemically, these non-invasive strains are indole-, aesculin- and salicin-positive. Also the non-sucrose-fermenting strains of O-serotypes 11 and 12 were non-invasive. The interaction with HeLa cells was not restricted to viable bacteria, since also bacterial cells inactivated by formalin or ultraviolet light could gain entrance to the HeLa cells. Heating of the bacteria to 100 degrees C for 30 min. completely inhibited their invasiveness. Monolayer cultures of porcine kidney cells were also invaded by strains which invaded HeLa cells.

Animals↗
PubMed1979

Differentiation of Yersinia enterocolitica strains in subgroups after biochemistry and serology.

A system for the differentiation of Yersinia enterocolotica strains and Yersinia enterocolitica-like strains is introduced using the biochemical and O-serological characters of the strains and their sources. Seven subgroups are proposed. I--III are indole-negative strains. IV include strains which are indole-positive but lack the ability to split aesculin and to ferment salicin. These strains mostly belong to serotype 0:8 and are found in the USA or in Canada. In subgroups V--VII the strains are also indole-positive but they can also ferment salicin and split aesculin. Subgroup V strains cannot ferment rhamnose. Subgroups VI and VII include the strains which ferment rhamnose, and in subgroups VII, to which strains with serotype 0.17 belong, melibiose is also often fermented. Using cross-agglutination studies it has been possible to make a subdividing of the serotypes 0:4, 0:5, 0:6 and 0:7.

Benzyl Alcohols↗
PubMed1978

A simple routine method for detecting hidden rheumatoid factors.

A new and simple routine method is described for detecting hidden rheumatoid factors in human serum. EDTA glycine and NaCl were used to liberate hidden rheumatoid factors and to inactivate complement before rheumatoid-factor activity was determined in a glycine--NaCl solution. Forty-nine out of 97 sera from individuals with seronegative rheumatoid arthritis gave positive reactions by this method. Rheumatoid sera with low titres by standard tests gave higher titres with the new method. The new method detects both IgM and IgG rheumatoid factors and is simple and suitable for use in routine medical laboratories. Used in parallel with the classical tests, it facilitates detection of hidden rheumatoid factors.

Arthritis, Rheumatoid↗
PubMed1978

Clinical aspects on 64 cases of juvenile and adult listeriosis in Sweden.

In 1958-74 altogether 64 cases of bacteriologically verified infections of Listeria monocytogenes were diagnosed in Sweden in children, aged more than 27 days, and in adults. Immunosuppression predisposed to the disease. Thus, many patients had co-existing disorders, such as leukemia and alcoholism. Sixteen patients had been treated with corticosteroids, which were combined with cytostatic drugs in nine. Meningoencephalitis was diagnosed in 52 patients and was fatal in 16. The clinical symptoms did not differ from those in purulent meningitis caused by other bacteria. In the cerebrospinal fluid the cellular response was dominated by polymorphonuclear cells in 29 patients and by mononuclear cells in 20. Ten patients had septicemia, which was fatal in four. Clinical symptoms were dominated by chills, high fever and general prostration. One patient had pleurisy and one an abscess of the neck; both recovered. Serotypes 1 and 4b prevailed and were equally common. Many patients developed raised antibody titers in both the O-agglutination test and the complement fixation test. The titers were often not positive until after a month. Moderate granulocytosis was the rule and monocytosis was rarely seen. Ampicillin alone or combined with an aminoglycoside seemed to be the drug of choice in the treatment of listeriosis. An alternative drug was tetracycline. Most deaths occurred within six days of onset of the illness. Early diagnosis and treatment were imperative. Most patients recovered and serious sequelae were rare.

Abscess↗
PubMed1976

HLA-antigen b27 in cases with joint affections in an outbreak of salmonellosis.

An outbreak of infection with Salmonella typhi murium occurred in southern Sweden in the summer of 1974. About 330 persons were infected; 91 were hospitalized. 13 of the 91 patients (9 men and 4 women) had symptoms of aseptical polyarthritis. The 13 patients with arthritis were HLA typed with a standard microlymphocytotoxicity test. 13 salmonellosis patients from the same epidemic but without arthritis and 446 healthy blood donors served as controls. Nine (69%) of the 13 patients with arthritis had HLA-B27 compared to 1 (8%) of the control patients and 44 (10%) of the blood donors. The observed association between HLA antigen B27 and reactive arthropathy following salmonella infection could be due to a function of a disease predisposing gene closely linked to HLA-B27.

Adolescent↗
PubMed1975

Arthritis associated with Yersinia enterocolitica infections.

74 patients, 42 females, 32 men-all over 10 years of age, with acute arthritis associated with infection with Yersinia enterocolitica are presented. The diagnosis was based on serological evidence in all cases (an agglutinin titre of 320 or more), and in 18 of the cases also a positive culture of Y. ent. from faeces. The erythrocyte sedimentation rate was very high in most cases. Acute enteritis, sometimes with abdominal pain, preceded the acute arthritis with a latent period of about 1-14 days. In 50% of the cases only one or two joints were involved, most often large joints such as knee, ankle and wrist. The symptoms were long-standing (2 months or longer) in two-thirds of the cases. Arthritis in connection with yersiniosis must therefore be considered a serious complication to an otherwise rather benign infection.

Acute Disease↗