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Biomedical subjects

S Witemeyer

Publications and source records attributed to S Witemeyer.

6 recordsLinked to original sources
PubMed1981

Gait analysis: a pilot study- a possible mode of assessment of lower limb function in juvenile chronic arthritis.

There is a need for some form of objective assessment of gait which can be used clinically. A method which measures the temporal and distance factors has been employed to assess the gait of patients. Variables have been selected which reflect the gait symmetry and others have been chosen which show the speed of walking and hos this is achieved. The method of presentation of results is discussed with particular attention to the use of these results in monitoring the progress of the patients.

Adolescent↗
PubMed1980

Foot function in juvenile chronic arthritis.

Measurement of the force distribution under the foot has been used to assess the effect of juvenile chronic arthritis on foot function. The results obtained from the feet of eight patients were compared with the feet of 11 normal children. The peak forces and contact times were measured for functional areas of the foot. When considered as a group, the patients had significantly reduced loading under all the toes and the two medial metatarsal heads, and increased contact time for the heel.

Adolescent↗
PubMed1978

A population of human cord blood mononuclear cells with surface alpha fetoprotein.

Suspensions of mononuclear cells from adult peripheral blood (PBL) and mononuclear cells from cord blood (CBL) were examined for the presence of surface alpha-fetoprotein (AFP) using a fluoresceinated F(ab')2 fragment of rabbit IgG anti-human AFP. The mean proportion of CBL with AFP was increased (10%) when compared with PBL (1%) although some CBL specimens did not demonstrate such an increase (range 0--15%). The presence of AFP on CBL could be either due to cytophilic AFP attached to a unique surface receptor or intrinsic AFP synthesis. The following observations could not distinguish between these two possibilities: (1) After treatment with trypsin, only minor reappearance of surface AFP could be observed in AFP-free medium in contrast to the larger numbers observed in medium containing AFP. Such selective reappearance depending on the media could be related to either cytophilic attachment of heterologous or homologous AFP or preferential stimulation of intrinsic AFP synthesis. (2) The reappearance of AFP positive CBL following trypsin treatment and incubation in media with or without AFP containing sera was inhibited by cyclohexamide. Such inhibition could be due to inhibition of synthesis of an AFP surface receptor or intrinsic AFP. (3) The shedding of surface AFP observed at 2--4 degrees C could be due to release of exogenous cytophilic AFP or the continued "turnover" of intrinsic AFP without concomitant AFP synthesis due to the cold temperature. Finally, the removal of AFP positive cells via selective depletion of B cells using bead columns coated with IgG-anti-IgG and the absence of depletion of AFP positive cells after successive gradient centrifugation of E-rosettes and cells with IgG-Fc receptors are consistent with the identity of AFP positive CBL as cells without IgG-Fc receptors or lymphocytes without conventional T-cell markers as defined by E-rosettes.

Cell Membrane↗
PubMed1976

A familial defect in cellular chemotaxis associated with redheadedness and recurrent infection.

This study describes a familial defect in polymorphonuclear leukocyte chemotaxis associated with redheadedness and recurrent infection in two of six siblings. Laboratory data indicate that this defect in chemotaxis is not associated with a concurrent defect in leukocyte bactericidal activity. Additional studies demonstrate that although these children experience recurrent infections, immunoglobulin levels (IgG, IgA, IgM, and IgE) and complement components (total hemolytic complement, Clq, C3 and C3PA) are all within normal limits. Measurements of PMN random mobility and phytohemagglutinin-stimulated lymphocyte transformation were also within normal limits. These studies demonstrate a familial PMN defect limited to leukocyte chemotaxis and associated with recurrent infection and possibly redheadedness.

Bacterial Infections↗