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Biomedical subjects

S Witte

Publications and source records attributed to S Witte.

At least 73 records · Page 4Linked to original sources
PubMed1978

The diagnostic significance of nuclear DNA measurement in cytologic smears of benign and malignant gastric lesions.

Gastric mucosa was obtained from 126 patients by endoscopic biopsy and subsequent cell brushing for histological, cytological and DNA cytophotometric studies. 23 cases were carcinomatous. DNA histogram evaluation for each case was carried out with special consideration of the position of the DNA stem line and the scatter of the measured DNA values. Additionally, DNA distribution characteristics were established for clinical or cytological diagnostic groups. By ascertaining relative mean ploidy values (U values) and relative frequency of euploid and polyploid values (Z values) in the sample populations, cell nuclear DNA determination was used as a criteria for differentiating between benign and malignant alterations of the stomach. The results allow optimistic prognosis concerning the use of cell nuclear DNA content as a significant, though not as the only measuring factor in automated diagnostic procedures.

Biopsy↗
PubMed1977

[Significance of cytology in diagnostics of non-malignant lesions of gastric mucosa (author's transl)].

The cytology of the stomach aims at detecting the carcinoma. For the obtaining of cell material today mainly endoscopically well-aimed techniques are applied. In other words: The diagnostic results decisively depend on the abilities of the endoscopist who has to discover a suspect region in the stomach and to take off the material in a well-aimed way. Under these aspects and prerequisites, in fact, any type of stomach cancer can be cytologically diagnosed. For the differentiation between tumourous cells and non-tumorous cells the changes of the gastric mucosa with non-malignant diseases are important (chronic gastritis, ulcer, erosion) for the cytologist. Often, with stomach cancer the stomach cell findings resemble those arrived at with non-malignant stomach diseases. Characteristic cytological findings with gastritis, ulcer and erosions are demonstrated. The clinical diagnostics of these diseases is the task of endoscopy and biopsy. The problem of the so-called false positive cell findings is discussed. Ways towards a quantitative diagnostics are being opened by cytophotometric methods. The author states first experience of his own gathered by applying the DNA-determination in individual cells and in the flow-through method.

Diagnostic Errors↗
PubMed1976

[Endoscopic tumor-cell diagnosis within the region of duodenum].

The technique spontaneously or siphoned after cholecystokinin stimulation. Our technique of cell collection within the region of the duodenum, the pancreas and the bile-ducts have been optimal performed by duodenoscopical methods. From the papilla of Vater, the cell brush abrasion is used. Pancreatic secretions are obtained by praepapillary drainage with a catheter after secretin stimulation or siphoned after canulation of the ductus Wirsungianus. Bile is obtained wth the same technique of material collection and processing is described. Characteristical tumor cell findings of the papilla of Vater, of the pancreas and the bile ducts are demonstrated and the cytodiagnostic's position within the tumor recognition in this area is discussed. We think the tumor cell search with the described duodenoscopical techniques as indicated in following cases: 1. suspicion of carcinoma of papilla of Vater, 2.obstructve jaundice, 3. in search of carcinoma of the pancreas.

Cytodiagnosis↗