Biomedical subjects
Publications and source records attributed to S Woźniak.
Serum laminin (sL--by means of ELISA method) was evaluated in 17 patients with tubal pregnancy (TP) and 25 healthy control subjects. In patients with ruptured TP sL was significantly elevated as compared to both the controls and the patients with unruptured TP (p < 0.001). The obtained results suggest the usefulness of sL measurements in clinical management of patients with symptoms of ectopic pregnancy.
In 45 gravidae (below 24 weeks) fetal fibronectin (fF) was measured in cervico-vaginal discharge and plasma fibronectin (pF) was evaluated in venous blood. Twenty women had cervical incompetence (CI) diagnosed and 25 healthy gravidae served as a control. The fF level in patients with CI (0.073 +/- 0.014 mg/ml) was significantly (p < 0.01) higher than that found in the control group (0.058 +/- 0.011 mg/ml). The same was true for pF (p < 0.001). A diagnostic value of fibronectin levels in patients suspected of cervical incompetence is suggested.
What we need in order to obtain good results in oesophageal reconstructive surgery is long enough segment of intestine with sufficient blood supply. Evaluation of the blood flow is very difficult and often only after completion of the mobilization and transposition of the intestine into the neck final evaluation can be made. In the cases with poor blood flow one must resign from the already mobilized intestine. In such situation the second operation with the use of different alimentary tract segment must be performed. In our practice we encountered 7 cases where it was necessary to mobilize the second intestinal segment in order to achieve success in the reconstruction of the oesophagus. In 3 cases during the first operation jejunum was used. In 3 cases the necrosis of mobilized jejunal segment forced us to perform the second operation. In two patients during the second operation right colon segment along with terminal ileum was used. The third was operated with the use of right colon. In 2 others right colon was used in the first operation. One of them was operated for the second time with the use of left colon. The other were operated with the use of ileum. 2 patients with the substitute from right colon along with the terminal ileum when operated for the second time had the jejunum and left colon segment used to bridge the gap. Mortality in our reconstructive operations was 28.57% (2/7).
Recent studies emphasise an important role of immunological mechanisms in pregnancy maintenance. Antiphospholipid antibody syndrome is responsible for 5-15% of recurrent pregnancy loss. Authors describe a successful pregnancy outcome after aspirin and heparin therapy in 26 years old woman with three previous pregnancy losses, with positive anticardiolipin antibodies and increased number of NK cells.
UNLABELLED: The aim of the study was to compare the serum laminin levels in patients with threatened abortion and healthy gravidae with uncomplicated pregnancy. MATERIAL AND METHODS: Twenty five pregnant women with menstrual arrest period ranging from 7 to 22 weeks, presenting with symptoms of threatened abortion (TA), were included into the study. Control group consisted of 25 healthy gravidae with uneventful course of pregnancy matched for the gestational age. Blood serum laminin was quantified by means of ELISA method using commercially available kits. RESULTS: Average serum laminin levels (S-L) measured in gravidae with threatened abortion was significantly higher than that of the control group. In patient with sonographically diagnosed trophoblast ablation the serum laminin was significantly elevated in comparison with the remaining patients of TA group, who had no sonographic abnormalities found. The patients with favorable outcome had mean serum laminin significantly lower than that of the patients with subsequent pregnancy loss. CONCLUSIONS: The observed difference in serum laminin level between patients with TA and patients with uncomplicated pregnancy seems to result from the release of laminin from trophoblast in cases when the integrity of the decidual/conceptual interface is disintegrated. This hypothesis is further supported by the finding of the high S-L in patients with the ablation of trophoblast. The obtained results suggest the prognostic value of S-L measurements in patients with imminent abortion.
Early complications after partial pancreatic resections and benign pancreatic tumours were analysed. 276 patients with pancreatic tumours were treated in the years 1979-1997. In 77 cases radical operation was performed. 65 patients underwent Whipple and 12--Traverso-Longmire pancreatoduodenectomy. Malignant tumour was found in 55 cases and 22 were benign. In 4 patients tumour's resection along with invaded portal vessels and portal confluence reconstruction was performed. These were the first cases with vessels resection operated in Poland. There were 2 post-operative deaths observed in that group. Complications in our material were as follows: pancreatico-jejunal anastomosis fistulae, haemorrhage from ulcers in gastro-jejunal anastomosis, diffuse peritonitis, haemorrhage from pancreatic stump vessels, ileus, acute renal insufficiency, pneumonia and myocardial infarct. Mortality in whole group was 11%. In the last 5 years due to our growing experience and some technical modifications mortality fell to 4.4%.
Studied were 25 healthy gravidae in the first or second trimester of pregnancy. Plasma fibronectin (pFN) was assayed in maternal blood serum and the fetal fibronectin (fFN) was quantified in cervico-vaginal secretion. The highest level of fFN was found in the cervico-vaginal secretion of the 1st trimester gravidae while the pFN levels gradually raised to reach its peak between 21 and 24 gestational weeks.
Studied were 25 healthy gravidae in the first or second trimester of pregnancy and 28 women with threatened abortion (TA). Plasma fibronectin (pFN) was assayed in maternal blood serum and the fetal fibronectin (fFN) was quantified in cervico-vaginal secretion. Patients with imminent abortion had significantly elevated levels of both pFN and fFN as compared with women with uncomplicated pregnancy. Within the TA group of patients, vaginal bleeding and/or trophoblast was associated with significant increase in fibronectin levels.
There were 30 infertile women with insufficient luteal phase of the cycle under the study. The hyperprolactinemia was diagnosed in 14 from 30 infertile women. In women with normal cycles the ovulation occurred in 18 day of the cycle. During the treatment with Bromocorn it was observed earlier, independently from the prolactin level in blood serum. The luteal phase of the cycle in controls lasted for 9.9 +/- 0.2 days and 11.8 +/- 0.5 days in women after one cycle with Bromocorn and 12.3 +/- 0.2 days after two cycles with Bromocorn. Duration of the cycles in these three studied groups differed statistically significantly (p < 0.001). In women treated with Bromocorn the second cycle phase lasted longer than 11 day and the differences in progesterone and LH levels in the middle of the cycle and at the end of the luteal phase were insignificant. The obtained results show, that Bromocorn could be a suitable method of treatment in the luteal phase insufficiency.
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Since 1993 during pancreatic resection routine intraoperative portography has been employed. Thus we are able to establish infiltration engaging portal vein and its branches. Facilitating decision making about resectability of the tumor. 29 portographies were performed. In eight cases malignant infiltration on portal vein was established. Because of that in seven cases no radical resection was undertaken.
Results of the operative treatment of Vater's papilla carcinoma in fifteen cases were analysed. Eleven patients had pancreatoduodenectomy according to Whipple, four had only local excision of Vater's papilla along with the tumour. All four had early recurrence and were re-operated by Whipple method. In our experience only radical pancreatoduodenectomy with regional lymphadenectomy, preferably Whipple type, gives chance of achieving the radical cure.
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