Enhanced myocardial viability with hypothermic storage in Euro-Collins solution.
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Animals↗
Biomedical subjects
S Woolley
Publications and source records attributed to S Woolley.
A possible role for prolactin in the control of human chorionic gonadotropin and estrogen secretion by the fetoplacental unit.
The effects of prolactin (PRL) on fetoplacental function were studied by measuring the beta subunit of human chorionic gonadotropin (hCG-beta), estradiol (E2), progesterone (P), and PRL concentrations throughout seven pregnancies in a control group (N = 6 women) and in three pregnant women with prolactinomas, who were receiving bromocriptine. In one of the latter, estriol (E3) was also assayed. Long-term suppression of PRL was associated with augmentation of hCG-beta at the first-treimester peak and in late pregnancy. Concomitant augmentation of E3 (in late gestation) and possibly E2, but not P, levels was also observed. This effect on hCG appeared dependent on PRL rather than the dopaminergic effect of bromocriptine. Short-term drug induced alterations in PRL (over 3 hours) during early pregnancy did not result in significant changes in hCG-beta or steroid concentrations. In each control pregnancy, a significant negative correlation (p less than 0.05) was observed between hCG-beta and PRL, while a significant positive correlation between the latter and E2 concentrations in these women was also demonstrated. Apart from its effect on lactation, osmoregulation, and gonadal and adrenal function, a further role for PRL during reproduction appears to be in the control of hCG and estrogen secretion in the fetoplacental unit.
Adult↗
Maternal plasma and amniotic fluid prolactin levels in normal and hypertensive pregnancy.
Prolactin levels in the plasma and amniotic fluid of 121 normal pregnant women, 78 women with pre-eclampsia and 30 women with essential hypertension complicating pregnancy were determined by radioimmunoassay. Mean prolactin levels in plasma, but not in amniotic fluid, were significantly lower than controls in the group with pre-eclampsia (P less than 0.01) and in the group with essential hypertension (P less than 0.05). These findings suggest altered production and/or clearance of prolactin from the maternal compartment in these patients and may explain their increased response to pressor agents.
Adolescent↗
Predictors of four functional tasks in patients with osteoarthritis of the knee.
PURPOSE: The purpose of this study was to identify predictors of performance on four functional tasks in adults with osteoarthritis (OA) of the knee. DESIGN: Descriptive correlation. METHODS: A voluntary sample of 78 community dwelling adults who reported knee pain and were previously diagnosed with osteoarthritis of the knee were timed while they performed the functional tasks of going down and getting up off of the floor and ascending and descending a flight of stairs as quickly as possible. Subjects were also evaluated for their joint pain while performing these activities, their leg strength, perceptions of joint pain, stiffness, functional ability, and other health status information. FINDINGS: This study indicates that knee extension strength (quadriceps), joint pain during the activity, perceptions of functional ability and body weight combined can predict between 39% and 56% of the variance in the time to perform four functional tasks in adults with OA of the knee. CONCLUSION: Interventions that improve quadriceps strength and reduce joint pain and body weight along with facilitating perceptions of functional ability may have a positive impact upon the ability to get down to and rise up off of the floor and ascend/descend stairs in adults with OA of the knee.
Activities of Daily Living↗
Correlates of self-efficacy in diabetes self-care among Hispanic adults with diabetes.
PURPOSE: The purpose of this study was to examine factors associated with increased diabetes self-efficacy among insulin-requiring Hispanic adults with diabetes. METHODS: A cross-sectional survey design was used to obtain self-reported data on a nonrandom sample of 97 insulin-requiring Hispanic adults with diabetes. The Insulin Management Diabetes Self-Efficacy Scale (IMDSES) was translated into Spanish and administered with a demographic questionnaire by trained bilingual/bicultural interviewers in each respondent's own home. Factor analysis of the IMDSES revealed 4 subscales that corresponded with major diabetes self-care management behaviors. RESULTS: Respondents gave low to average self-efficacy ratings on their ability to manage all aspects of their disease. Behaviors that required problem solving in changing circumstances received the lowest scores. Attending diabetes classes and having home nursing visits were associated with an increased sense of self-efficacy, particularly as it related to diet and insulin. English-speaking ability was associated with a general sense of self-efficacy in managing diabetes care. CONCLUSIONS: The model tested was able to explain modest levels of self-efficacy, particularly in 2 of the most important diabetes management areas, insulin and diet management.
Adult↗