PubMed Health⌕ Search

Biomedical subjects

S X Fu

Publications and source records attributed to S X Fu.

At least 37 records · Page 2Linked to original sources
PubMed1989

Prophylactic effects of m-nisoldipine and nisoldipine on reperfusion arrhythmias exacerbated by free radical generating system in Langendorff heart of rat.

Xanthine-xanthine oxidase (X-XOD, 500 mumol/L + 100 nmol/L) free radical generating system was perfused 10 min prior to coronary artery ligation until the end of the experiment. It exacerbated the reperfusion ventricular fibrillation, reduced the activities of superoxide dismutase and catalase and increased the contents of malondialdehyde in Langendorff heart of rats. m-Nisoldipine or nisoldipine (0.05 mumol/L) was perfused 10 min prior to coronary artery ligation until the end of the experiment. They prevented reperfusion arrhythmias exacerbated by X-XOD and decreased the free radicals generated by X-XOD.

Animals↗
PubMed1989

[Effects of m-nisoldipine on ischemic arrhythmia in conscious rats].

m-Nisoldipine iv 3, 5 and 10 micrograms/kg before coronary artery ligation markedly reduced the early ischemic arrhythmia in conscious rats. Nifedipine iv 5 and 10 micrograms/kg had the same effect on preventing ischemic arrhythmia. Nisoldipine was less effective than m-nisoldipine at equal doses. Myocardial infarct size was reduced and electrical stability of the myocardium was markedly improved as a result of the increment in VDT, VFT and VERP. These effects may be related to the mechanisms of their respective antiarrhythmic actions. It is unlikely that these calcium antagonists prevent ischemic arrhythmia by improving the blood supply to the ischemic myocardium.

Animals↗