Mucocutaneous lesions in the Behçet syndrome.
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Biomedical subjects
Publications and source records attributed to S Yalcin.
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1. An experiment was conducted to determine the effect of husbandry systems on bone characteristics and body weight. Broilers were reared in 5 different husbandry systems: wire mesh (WM) floored cages from 0 to 7 weeks; WM floored cages from 0 to 3 weeks and then transferred to floor pens; plastic mesh (PM) floored cages from 0 to 7 weeks; PM floored cages from 0 to 3 weeks and then transferred to floor pens; floor pens from 0 to 7 weeks. 2. Body weight at 3 weeks of age was affected by the husbandry systems, being greatest for the birds reared in floor pens. At 7 weeks of age, male broilers reared in PM floored cages had the lowest body weight and body weight gain from 4 to 7 weeks. 3. Humerus weight and ash content were affected by cage rearing whereas tibia weight and ash were not. Birds reared in PM cages had shorter tibia and humeri than birds reared in floor pens.
Nineteen, randomly selected male patients with lepromatous leprosy were evaluated electrophysiologically. All of these patients had long-standing disease and were treated with dapsone alone. There were statistically significant differences between the values obtained in this group of leprosy patients compared to 20 age-matched controls in auditory brain stem evoked potentials (ABEP). The findings are consistent with a pathologic process located mainly between the cochlear nucleus and the lateral lemniscus in the auditory brain stem pathways. It should be emphasized that our patients had long-standing disease which was treated with dapsone. ABEP could very well be different in leprosy patients diagnosed early and treated for relatively short periods with multidrug therapy. Brain stem evoked response audiometry may be useful for evaluating the possibility of brain stem involvement in leprosy.
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An experiment was conducted to determine the effect of divergent selection for tibial dyschondroplasia (TD) on live performance of broilers. Broilers used in the experiment were produced from the parental lines selected for high (H) and low (L) incidence of TD and a randombred control (C) line. Diallel crosses were made between H and L lines. The offspring produced were HH, HL, LH, LL, and CC, where the first letter refers to sire line and the second letter refers to dam line. Body weights, average daily body weight gains, and exponential growth rates were determined at weekly intervals. The incidence of TD was recorded at 4 and 7 wk of age. There was no difference among body weights of lines up to 5 wk of age. Sire lines influenced body weights of birds from 5 to 7 wk of age. A significant interaction between sire and dam lines for body weight was the result of decreased body weights of birds in the HH line from 5 to 6 wk of age. There was a similar interaction for body weight gain, which resulted in a slower growth rate of birds in the HH line from 3 to 5 wk of age. Tibial dyschondroplasia incidence was 84.1 and 92.0% in the HH line, 5.6 and 5.4% in the LL line, and 7.0 and 13.2% in the CC line at 4 and 7 wk of age, respectively. It was suggested that genetic predisposition for TD was independent of body weight.
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We explored the prevalence of human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7) infections in 16 renal transplant recipients and 16 healthy controls by virus isolation, serology, polymerase chain reaction (PCR) followed by dot blot hybridization. HHV-6 variant A was isolated from one renal transplant recipient. Seven patients (44%) and six controls (38%) had HHV-6 variant B DNA in their peripheral blood mononuclear cells. The prevalence of HHV-7 DNA was found to be the same in patients and controls (19%).
Peripheral blood mononuclear cells collected from 13 patients with chronic fatigue syndrome and 13 healthy controls were analyzed for the presence of human herpesvirus 6 (HHV-6) DNA by variant-specific polymerase chain reaction and dot blot hybridization. HHV-6 DNA was detected in 7 of 13 (53%) patients, and of those 7 patients, 4 were positive for HHV-6 variant A DNA and 3 were for variant B. No HHV-6 DNA was detected in the controls. Serum antibody titers to the late antigen and antibody prevalence to the early antigen of HHV-6 were significantly higher in the patient group. These results suggest active replication of HHV-6 in patients with chronic fatigue syndrome.
Thorough X-ray examination is a valuable adjunct in the clinical assessment of supernumerary teeth. Three cases of supernumerary teeth comprising paramolars and molars are presented with radiographic documentation. All the patients received surgical treatment after full clinical and radiographic evaluation.
A primary Ewing's tumor in the mandible is reported, and the diagnostic imaging features of this lesion are discussed. Modalities used included panoramic and plain films, computed tomography, and 99mTc-MDP scintigraphy.
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Cynomolgus and African green monkeys were inoculated with human herpesvirus 6 (HHV-6). An antibody response was first observed 10 days and 5 days after inoculation of cynomolgus monkeys and African green monkeys, respectively, and was detectable for the duration of the experiment (33 days). HHV-6 DNA was first detected by the polymerase chain reaction in mononuclear cells of one cynomolgus monkey and one African green monkey 10 days after virus inoculation, and in a total of three of four cynomolgus monkeys (75%) and four of five African green monkeys (80%) later after inoculation. Furthermore, HHV-6 DNA was detected in the lymph nodes and spleen of monkeys killed 33 days after virus inoculation. A rash was observed on the trunk of one African green monkey 13 days after virus inoculation, otherwise the infection was asymptomatic. When mononuclear cells from both groups of monkeys were cultured in medium containing concanavalin A and interleukin 2, and infected with HHV-6 in vitro, virus replication was observed. The data suggest that HHV-6 infects these species of monkey and that this system could be useful as an animal model of HHV-6 infection.
A case of paresthesia of the mental nerve following over-extension of root canal filling material into the inferior alveolar canal is presented. The causes of this complication are discussed and the importance of performing surgical treatment as early as possible is emphasized.
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The susceptibilities of seven T-cell lines to human herpesvirus 6 (HHV-6) infection were examined. MT-4 cells were the most susceptible of these lines to infection with this virus. Therefore, chemically adhered MT-4 cell monolayers were used for infectious HHV-6 assay by indirect immunofluorescent-antibody (IFA) staining. When cell monolayers were fixed 30 to 45 h postinfection, the foci stained with IFA were easy to count and a linear relationship was observed between the number of foci and the virus concentration. MT-4 cell monolayers were also used for a focus reduction neutralizing-antibody test. In this test, sera from patients in the convalescent stage of exanthem subitum all showed significant neutralizing activity (1:80 to 1:320), whereas sera from patients in the acute stage of disease showed no detectable neutralizing activity. The titers of neutralizing antibody correlated well with the levels of anti-HHV-6 antibodies detected by IFA.
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