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Biomedical subjects

S Yeager

Publications and source records attributed to S Yeager.

5 recordsLinked to original sources
PubMed1998

Epidemic Legionnaires' disease two decades later: old sources, new diagnostic methods.

In July 1995 we investigated a pneumonia outbreak in a Pennsylvania town. We conducted epidemiological and molecular microbiological studies to determine the outbreak source and interrupt transmission of disease. Legionnaires' disease (LD) was quickly identified by urine antigen testing, and a newly developed immunohistochemical stain confirmed nosocomial transmission to a hospital inpatient. LD was confirmed in 22 patients. Case-patients were more likely than controls to have been within 1,000 feet of the hospital (matched odds ratio, 21.0; 95% confidence interval, 2.9-368) during the 2 weeks prior to illness. Legionella pneumophila serogroup 1 (Lp-1) was isolated from hospital cooling towers (CTs) and rooftop air samples but not from hospital potable water or community CTs. Hospital CT and air Lp-1 isolates matched all five patient isolates by monoclonal antibody, arbitrarily primed polymerase chain reaction, and pulsed-field gel electrophoresis subtyping. Strategies to prevent LD must include minimizing transmission from CTs.

Adult↗
PubMed1993

Perinatal and postnatal chest sonography.

Sonography is the primary method used to image the fetal chest. Many significant congenital anomalies such as pleural effusion, congenital diaphragmatic hernia, cystic adenomatoid malformation, pulmonary sequestration, and congenital heart disease can be detected during early prenatal sonography. Fetal sonography also permits accurate assessment of the severity of these processes, allowing for parental counseling and optimal planning of postnatal care. After birth, sonography is the primary method for evaluating cardiac anatomy and diagnosing congenital heart disease. Sonography also serves as a useful adjunct to plain film radiology and other modalities in evaluation of the mediastinum, diaphragm, pleura, and chest wall.

Bronchopulmonary Sequestration↗
PubMed1983

Measurement of systemic and pulmonary blood flow and QP/QS ratio using Doppler and two-dimensional echocardiography.

A noninvasive method for measuring systemic and pulmonary blood flow using Doppler velocimetry combined with 2-dimensional (2-D) echocardiography has been developed. High correlations were found between Fick- and Doppler-derived indexed measurements of systemic and pulmonary flow as well as the pulmonary to systemic flow ratio in 33 patients undergoing cardiac catheterization (systemic flow [n = 28], r = 0.78; pulmonary flow [n = 21], r = 0.88; Qp/Qs ratio [n = 24], r = 0.85). The random errors of the 2 methods were not significantly different. Outflow tract obstruction, semilunar valve regurgitation, and patent ductus arteriosus were the only lesions in which limitations to the use of this method were encountered. We anticipate that this method will be of use in initial and serial evaluations of adult and pediatric patients with low cardiac output or intracardiac shunts.

Adolescent↗
PubMed1980

Effect of application force on noninvasive measurements of intracranial pressure.

Application of the Ladd fiberoptic sensor to the anterior fontanel of the human newborn has been used as a method for monitoring intracranial pressure noninvasively. This study measures the effect of varying the force with which the sensor is applied to the fontanel. The Ladd sensor readings of five preterm human infants were continuously monitored while sensor application force was increased in a stepwise manner. The Ladd sensor readings for each infant varied with the force applied. In one infant sensor application was gradually increased while direct measurements of lumbar CSF pressure were made. Ladd sensor readings in this infant increased with increasing application force, while lumbar CSF pressure remained unchanged. It is concluded that readings obtained with the Ladd sensor applied to the anterior fontanel of the human infant depend on the force with which the sensor is applied. The effect of application force must be taken into account if noninvasive measurements of intracranial pressure are to be made with the Ladd device.

Humans↗