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Biomedical subjects

S Zaluski

Publications and source records attributed to S Zaluski.

At least 19 recordsLinked to original sources

Pseudomonas aeruginosa endophthalmitis caused by contamination of the internal fluid pathways of a phacoemulsifier.

PURPOSE: To report 4 cases of Pseudomonas aeruginosa endophthalmitis caused by internal contamination of the internal pathways of a phacoemulsifier. SETTING: Ophthalmology Center, Perpignan, France. METHODS: Four clinical cases of postoperative endophthalmitis occurred after phacoemulsification. An investigation was necessary to prove the cause of the bacteriological contamination. RESULTS: Serotyping and ribotyping of the Pseudomonas aeruginosa strains obtained from the vitreous samples and from the phacoemulsifier showed that all these strains were identical and that the initial site of the contamination was the phacoemulsifier. CONCLUSIONS: The profession should be cognizant of this cause of endophthalmitis, although its occurrence is rare. Cataract surgeons should test samples from the collection bags of their phacoemulsifiers to ensure there is no bacteriological contamination.

Aged↗

[Surveillance using vitreo-fluoro-photometry of diabetics treated with an insulin pump, without or with minimal retinopathy. Results after 3 years].

In order to appreciate quantitatively the effect of strict metabolic control obtained with continuous insulin infusion, we have carried out a clinical, angiographical and vitreofluorophotometrical follow-up during a mean period of 36 months, on 21 eyes of 11 patients treated with intraperitoneal insulin pump for brittle diabetes. Patients had no (5 patients) or minimal retinopathy (less than 10 microanevrysms, no exsudate or ischemic areas) (6 patients). At the same time, vitreous fluorophotometry was performed on one eye of 15 volunteer patients without any ocular or general pathology. Vitreous fluorophotometry measurements were made with the Fluorotron Master; after substraction of background autofluorescence, and spread function, results are expressed by the level of posterior vitreous penetration by fluorescein. Good metabolic control was achieved during the study (mean +/- S.D. glycemia = 1.47 g/l +/- 0.21, mean +/- S.D. HbA1 = 7.99% +/- 0.84). Final visual acuities were identical to initial ones, there was no angiographical evolution of the retinopathy, and final vitreous fluorophotometry data (OD = 4.19 10(-6)/mn +/- 0.44 S.E.M., OS = 3.28 10(-6)/mn +/- 0.51 S.E.M.) did not statistically differ from the initial data (OD = 3.88 10(-6)/mn +/- 0.49 S.E.M., OS = 4.08 10(-6)/mn +/- 0.64 S.E.M.). On the contrary, volunteers' measurements (2.15 10(-6)/mn +/- 0.26 S.E.M.) were significantly lower than initial (p less than 0.01) and final (p less than 0.05) diabetics' measurements. These results confirm the early breakdown of the blood-retinal barrier during diabetic disease, and would support the notion of a favorable effect of strict metabolic control on early stages of diabetic retinopathy.

Adult↗

[Course of retinopathy in premature infants treated by cryopexy].

Beneficial effect of cryopexy on 180 degrees to 360 degrees of avascular retina was demonstrated in 7 prematurely born infants (14 eyes) affected with advanced retinopathy of prematurity. Intravitreous new vessels were present in all eyes before treatment. The treatment of one eye was supplemented with scleral indentation. Only one of the treated eyes went on unfavourably with retrolental fibroplasia and consecutive loss of visual acuity. We believe that cryopexy, when administered promptly, when limited to the avascular zone, and when supplemented with scleral indentation in cases with important vitreous traction, is a valuable treatment with fewer risks than unchecked evolution for advanced cases of retinopathy of prematurity.

Cryosurgery↗

Beneficial effect of glycaemic improvement in non-ischaemic forms of diabetic retinopathy: a 3-year follow-up.

Recent studies have suggested that optimal glucose control fails to arrest or even worsens background retinopathy possibly by aggravating retinal ischaemia. Fourteen insulin-dependent diabetic patients, aged 34 +/- 11 years (mean +/- SD) treated by long-term intraperitoneal insulin infusion using portable pumps, were followed for 3 years. Preproliferative or proliferative lesions on ophthalmoscopy and large non-perfused areas on fluorescein angiography were exclusion criteria. Six patients were found to have minimal and 8 mild background retinopathy. The patients were retrospectively assigned to two comparable groups except for their glycaemic equilibrium under insulin infusion: average control (n = 6) and excellent control (n = 8), although glycaemic control was significantly improved in all cases when compared to previous conventional therapy. Fluorescein changes were scored blindly and independently by 3 ophthalmologists according to modifications of fluorescein diffusion and capillary abnormalities. The two types of retinal lesions improved gradually in 10 patients and deteriorated in only 1 patient, although not progressing to proliferative retinopathy. Structural improvements were significantly more frequent in the excellently controlled group. We conclude that non-ischaemic lesions may still be arrested and even improved by tight metabolic control.

Adult↗

[Study of the visual field using automated static perimetry following panretinal photocoagulation in the diabetic].

Twelve diabetic patients presenting a preproliferative or proliferative retinopathy were the subjects of our study. We studied the modifications of the visual fields, analyzed by computerized perimetry, after panretinal photocoagulation (PRP). For every patient, two techniques of PRP were applied, one on each eye: C: conventional scattered treatment, G: cluster technique. Computerized perimetry was done within 10 days prior to PRP, and 4 to 8 weeks following it. We used the Octopus 500, programs 36 (0 to 30 degrees) and 44 (30 to 60 degrees). It appears that, before any treatment, there is a loss of retinal sensitivity excepted the more central zone. Concerning the loss of sensitivity, although the number of laser burns, is greater in group G, there is no statistical significative difference between the 2 groups. Nevertheless, it seems to be more heterogeneous in group G. However, we have not studied the visual field modifications after confluent PRP using up to 5,000 500 micron laser burns. Although there is a loss of retinal sensitivity after PRP, none of our patients complained of it. PRP seems to us to be the only treatment able to prevent the natural evolution of preproliferative or proliferative diabetic retinopathies.

Adult↗

[Improvement of retinopathy in the diabetic treated with an intraperitoneal insulin pump].

The recent development of continuous insulin infusion by pump as a treatment method of diabetics and the fact that several publications have shown some doubt as to the efficiency of this method of treatment on the development of diabetic retinopathy, have led us to study this problem. In our study we have followed 24 patients for an average of 22 months (13-41). These patients were diabetics type I, non-obese, normotensive and were divided into three groups based on the extent of their diabetic retinopathy. Group I: no retinopathy, 5 patients. Group 2: background retinopathy without ischaemia, 14 patients. Group 3: ischaemic retinopathy, 5 patients. Only patients from group 3 where subjected to photocoagulation. The above classification was based on angiographic findings and we compared angiograms before and after treatment. In group I, none of the patients developed diabetic retinopathy. In group 2, there was only one aggravation of the preexisting retinopathy, however without the development of proliferative changes. In group 3, the favourable outcome was mainly due to treatment by photocoagulation. The different classification of diabetic retinopathy that we have adopted into ischaemic and non-ischaemic forms based on angiographic findings might explain our favourable results. The classification into background and proliferative retinopathy does not indicate in the background type the relative importance of the oedema and the ischaemia. We suggest that the improved glycemic control obtained by continuous insulin infusion has a favourable outcome on non-ischaemic type of diabetic retinopathy, whereas photocoagulation remains the treatment of choice in ischaemic retinopathy.

Adult↗

[Acute necrotizing retinitis. Apropos of 2 cases].

Two cases of acute retinal necrosis are reported, the etiology of this affection being priorly defined. The lesions were bilateral in the first case, and retinal detachment developed: the first eye was inoperable, and surgery was unsuccessful for the second eye in spite of a salvage vitrectomy after a classical operation. We therefore treated the second case with immediate and massive corticotherapy, and, mainly, preventive total vitrectomy as soon as the first signs of vitreous retraction appeared and before the occurrence of retinal detachment. This preventive vitrectomy, not previously described to our knowledge, seems to provide favorable results.

Acute Disease↗