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Biomedical subjects

S Zamboni

Publications and source records attributed to S Zamboni.

At least 37 records · Page 2Linked to original sources
PubMed1990

[Von Hippel syndrome with recurrent pheochromocytoma].

A patient with Von Hippel disease is described. The Von Hippel syndrome is a genetic disease characterized by a retinal angiomatosis and multiple tumors (renal and pancreatic sites are common). The pheochromocytoma is-on the contrary-very uncommon and the association with 2 pheochromocytomas has probably never been reported. In our case, a double pheochromocytoma (the first in 1973, the second in 1986) was present, in conjunction with a thyroid tumor and with an anomalous renal vein (circumaortic ring). The clinical picture was characterized by a severe hypertension and a fourth stage retinopathy. A correct diagnosis was established only 10 years after the clinical exordium. The thyroidectomy and the ablation of both the pheochromocytomas were necessary.

Adrenal Gland Neoplasms↗
PubMed1989

Dietary behaviour in psoriatic patients.

Two hundred and nineteen psoriatic in-patients and 747 non-psoriatic subjects were asked to report in a semiquantitative, self-administered questionnaire on the frequency of consumption of different foodstuffs and cooking and seasoning fats and the daily intake of alcohol (glasses/day) and coffee (cups/day). According to this a definite score was assigned to each of the 46 food items, which were divided into five groups: carbohydrates (CH), low-fat foods (LFF), high-fat foods (HFF), saturated fats (SF) and polyunsaturated fats (PUF) and the alcohol consumption in grams/day was calculated. The mean scores for each food group and the means of alcohol (grams/day) and coffee (cups/day) intake were compared in the two groups, after age-adjustment through ANOCOVA. Psoriatic patients showed higher scores for HFF and SF in males and for CH, HFF, SF and PUF in females and a higher intake of alcohol in both sexes. These dietary habits could explain the higher prevalence of metabolic abnormalities in psoriatic patients.

Adult↗
PubMed1989

[Erythrocyte Li/Na countertransport and correlated variables in a randomized sample of population].

A genetically determined alteration of the cell membrane sodium metabolism may play a role in the pathogenesis of essential hypertension. The most consistent finding in patients with essential hypertension is an increased red blood cell Li/Na exchange (countertransport). It is genetically determined but it is also associated to potentially confounding variables (body weight, race, age and so on). The present study investigates the relationship between red cell Li/Na countertransport and various potentially confounding variables in a random sample of the population. It shows that this membrane cation transport system is increased in males compared to females and significantly correlated to body mass index in males and to blood pressure, alcohol consumption and, negatively, to urinary calcium excretion in females. Since body weight and alcohol consumption are correlated to blood pressure in several epidemiological studies, it can be hypothesized that they influence blood pressure control through an alteration of the cell membrane sodium transport.

Adult↗
PubMed1988

Captopril in elderly hypertensive patients. Results from a multicenter Italian trial.

In this study, 953 patients (48 percent men) more than 60 years old with mild to moderate hypertension (class I or II) were included. After a two-week wash-out period, a starting dosage of captopril--12.5 mg twice a day--was given. Patients were examined after one and three weeks and, subsequently, at monthly intervals for a total period of four months. The dosage was adjusted to a maximum of 50 mg twice a day plus, when needed, 25 mg of hydrochlorothiazide per day. Thirty-two patients were lost to follow-up, 10 withdrew because of inadequate control of blood pressure, and only 21 (2 percent) dropped out because of side effects. Mean blood pressure decreased from 184/104 to 152/87 mm Hg. The lowest dosage (25 mg a day) was sufficient to control blood pressure in 15 percent of patients, 31 percent needed 50 mg a day, and 24 percent required 100 mg a day. Hydrochlorothiazide was added to the captopril regimen in 30 percent. No substantial changes in biochemical variables or electrocardiographic results were observed. "Quality of life" (judged as physical fitness, positive well being, mood, and sexual desire) remarkably improved.

Aged↗
PubMed1988

Relationship between body weight and blood pressure and some metabolic parameters in psoriatic patients.

The relationship between body weight and blood pressure, total serum cholesterol, triglycerides, uric acid and glucose was investigated in 203 psoriatic patients in comparison with 904 healthy controls. In the psoriatic patients, these parameters were clearly related to their body weight. Those psoriatic patients of normal weight exhibited lower mean values of all the parameters compared with overweight psoriatic patients while they did not differ from control subjects of normal weight. Our results suggest that only overweight psoriatic patients exhibit the metabolic abnormalities frequently reported in the literature, while psoriatic patients of normal weight do not differ from the general population in this respect.

Adult↗
PubMed1988

[Distributions, mean values and correlations of various coronary risk factors in a population of Veneto].

During the National Research Council (CNR) program called Atherosclerosis-Risk Factors 2 (ATS-RF2) a random sample of 1903 subjects (50.1% male) aged 20-59 years was examined in the general population of Mirano-Venice. Mean values of serum total cholesterol and triglycerides, body mass index, as well as systolic and diastolic blood pressure were assessed. On the whole these turned out to be higher in men and increased with age. The continuously distributed variables showed an approximately normal distribution and a close correlation. Comparing our results with those obtained by other Italian units co-operating in the same CNR program, different levels of serum total cholesterol and systolic blood pressure were observed. The overall risk factor pattern in northern Italian regions is closer to that reported in the literature for central European countries than to that of southern Italian regions. These findings might explain why mortality due to ischaemic heart disease is higher in northern Italy and becomes progressively smaller in central and southern Italy.

Adult↗
PubMed1988

[Incidence of aortic recoarctation in 161 patients after a mean follow-up of 8 years. The usefulness of pressure gradient measurement at rest and following exercise and of digital angiography].

The incidence of aortic recoarctation has been evaluated after a mean follow-up period of 8.2 years in 161 patients aged from 2 to 54 years at the time of the operation. To this aim, blood pressure levels in the upper and lower limbs were measured at rest and after bicycle ergometer exercise. Patients whose systolic pressure gradient was significant (either above 20 mmHg at rest or 35 mmHg after exercise) underwent aortic digital angiography. Aortic coarctation was diagnosed when the ratio of the aortic area at the site of the operation was less than 40% of that at diaphragmatic level (Frederiksen's index III). Thus the overall incidence of recoarctation was 10.1%. All patients with a significant gradient at rest also showed a significant gradient after exercise. This suggests that it is worthwhile performing digital angiography directly, without exercise testing, in these patients. However, 39.8% of the patients without significant rest gradients displayed a significant gradient after exercise. On the whole, only 21.4% of the patients with a significant gradient after exercise had signs of recoarctation on digital angiography.

Adolescent↗
PubMed1987

Electrocardiographic findings in hypertensive patients of a population sample. Role of sex, age, and antihypertensive treatment.

During the initial phase of the World Health Organization (WHO) "Community Control Program of Hypertension" in Italy, 1190 subjects with high blood pressure derived from a general population random sample (5856 people of both sexes, aged 20 to 64 years) were enrolled in a hypertension register. At the registration visit (RV), each of them gave case history details and underwent a complete clinical examination, blood and urine tests, and a standard 12-lead electrocardiogram (ECG). All the ECGs were read by a single coder, using the second version of the Minnesota Code (MC). We calculated the prevalence of electrocardiographic codes according to sex, age, and the state of antihypertensive treatment. The overall prevalence of electrocardiographic abnormalities (i.e., all codes except 1:0 and isolated 9:4) was 40.8% with a slightly higher prevalence in males than in females: 42.4% versus 39.4%. Codes related to left ventricular hypertrophy (LVH) (3:1 or 3:3) were also more frequent in males (21.2%) than in females (14.5%) but not those related to ischemia (4:1-4:3 or 5:1-5:3). In fact, group 4 codes were present in 4.0% of males and 16.1% of females; group 5 codes, in 5.7% of males and 18.1% of females. Abnormal codes generally increased with increasing age, but those related to LVH did not follow this general rule in males. In fact, in the age class 20-29 years, codes 3:1 were found in 11.1% and codes 3:3 in 17.5% of the subjects, whereas the corresponding frequencies in the oldest age group (60-64 years) were 15.2% and 12.4%, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1986

[Electrocardiographic changes in a cohort of hypertensive patients in a community intervention program].

A pilot project for the control of hypertension in the Community was carried out in Italy as a part of the WHO Programme "Community Control of Hypertension". 1190 subjects identified as hypertensive (BP greater than or equal to 160 and/or 95 mmHg at two subsequent measurements, or under treatment) during the screening of a random sample of the population between 20 and 64 years in the District of Camposampiero (Padova) were enrolled in a Hypertension Register during a subsequent visit (Registration Visit: VR) carried out two months after the screening. In the following 5 years they were recalled about once a year at a Hypertension Clinic for a complete visit (VA). On both the VR and the VAs a resting electrocardiogram (ECG) was recorded and subsequently assessed according to the Minnesota Code (MC). Out of the 1190 registered hypertensive subjects, 872 (400 males and 472 females) participated in the last VA visit after 5 years, which corresponds to an overall participation rate of 69.4% in males (M) and 76.9% in females (F). Among subjects with normal and abnormal ECG at the VR, the participation rates at the last VA were, respectively, 67.9 and 71.5% in M (not significant difference); 80.0% and 70.8% in F (significant difference: P less than 0.001). Between the VR and the last VA the mean BP values of the 872 subjects investigated decreased from 162. 9/102.2 mmHg to 148. 6/90.4 mmHg in M and from 168. 7/102.2 mmHg to 155. 3/91.7 mmHg in F. The rate of abnormal ECGs increased from 44.0% to 50.3% in M and from 36.4% to 47.9% in F, involving most single items and all the classes of the MC with the exception of classes 8 and 9. The items which diminished generally had a rather low prevalence or were those indicating minor abnormalities. The apparent regression of some pathological patterns could actually be accounted for by a shift towards more severe abnormalities. The most remarkable changes occurred in codes indicating respectively left ventricular hypertrophy (3: 1 or 3: 3) and myocardial ischaemia (4: 1-3 or 5: 1-3 or 7: 1).(ABSTRACT TRUNCATED AT 400 WORDS)

Adult↗
PubMed1985

Intra-erythrocytic sodium content in normotensive offspring of normotensive and hypertensive subjects: an epidemiological study.

An increase in intra-erythrocytic sodium (IENa) content has been proposed as a genetic marker of essential hypertension. Intra-erythrocytic sodium was studied using hypotonic lysis and flame photometry after four washings with isotonic MgCl2 in 240 normotensive subjects (aged 10-45 years) on a free diet with (F+, 121 patients) or without (F-, 119 patients) hypertensive parents, recruited from a random sample of the general population. Systolic blood pressure was significantly higher in males F+ than in males F- (130 +/- 2 versus 125 +/- 2 mmHg, mean +/- s.e.m., P < 0.05), while IENa did not differ. In contrast, intra-erythrocytic potassium content (IEK) was significantly lower and red cell sodium potassium (Na:K) ratio significantly higher in F+ than F-. This might reflect decreased NaK pump activity, or increased membrane permeability to cations which causes increased K leakage. No differences in blood pressure, IENa or IEK showed in female F+ versus F-. It is concluded that IENa is not a genetic marker of hypertension, and that it is probably influenced by exogenous factors. Being associated with differences in blood pressure, the abnormalities of IEK and Na:K ratio might be pathogenetically linked to an early increase in blood pressure.

Adolescent↗
PubMed1985

Electrocardiograms in hypertensive subjects from a population random sample: basic characteristics and correlations with some biological variables.

During the initial phase of the WHO "Community Control Programme of Hypertension" in Italy, 1,190 hypertensives (of both sexes, aged 20-64) were identified through the screnning of 5,856 people randomly selected from the whole population of the community of Camposampiero (Padova), and had a standard ECG tracing recorded. ECGs were all read according to the 2nd version of the Minnesota code (MC), by only one coder. First of all, the prevalence of the various items of MC in the two sexes was calculated. Absolutely normal ECGs (item 1-0) were found in 41.1% of the examined subjects; another 23.3% had only a shift of the transition zone to the right or to the left (items 9-4). Among pathological codes, the most frequent were those of class 3 relating to left ventricular hypertrophy (LVH) (i.e. 3:1 or 3:3) and those of classes 4, 5 and 7 relating to myocardial ischaemia (ISC) (i.e. 4:1-3 or 5:1-3 or 7-1). The overall frequencies of LVH and, respectively, of ISC (calculated by suitably grouping the above described items) were as follows. LVH: 21.3% in males (M), 14.6% in females (F); ISC: 5.7% in M, 18.1% in F. A significant (p less than 0.005) positive correlation with age was found both for LVH and ISC codes in F, only for ISC codes in M. A significant negative correlation between LVH codes and body mass index (BMI) was instead evident only in males.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1985

[Psychological effects in the drug treatment of arterial hypertension. A study during a community preventive program].

The possibility that antihypertensive drug treatment may induce neurotic symptoms was investigated in a random sample of 114 hypertensives enrolled in an "Hypertension Register" by means of the Kellner and Sheffield Symptom Rating Test (S.R.T.). Of them 73 were on antihypertensive treatment; 41 untreated subjects constituted the control group. Covariance analysis adjusting for age and diastolic blood pressure was used as a statistical test. The comparison between treated and not treated hypertensive subjects did not show any significant difference either for total S.R.T. score (12.6 vs 10.6 in M, 11.6 vs 14.6 in F), or for the partial scores of anxiety (3.5 vs 3.0 in M, 3.1 vs 3.4 in F), depression (2.4 vs 2.2 in M, 2.7 vs 3.5 in F), somatization (4.2 vs 3.2 in M, 3.9 vs 5.6 in F), inadequacy (2.4 vs 2.1 in M, 1.9 vs 2.1 in F). Taking into account the total group (M + F) of treated hypertensives, no significant differences were observed between different treatments (reserpine, alphamethyldopa, clonidine; beta-blockers, diuretics). However beta-blockers and clonidine showed the highest scores for total S.R.T. score (17.3 and 13.2 respectively). The study suggests that the antihypertensive drugs taken into consideration, at least at the given regime, do not induce such psychological side effects as to prevent them being used in a programme of secondary prevention of hypertension.

Antihypertensive Agents↗
PubMed1984

Hypertension and neuroticism.

324 normo- and hypertensive subjects were investigated for neurotic symptoms during outpatient screening for arterial hypertension. The patients were randomly selected and subdivided into three groups: 'new' hypertensives, 'old' hypertensives and normotensives. Neurotic symptoms were evaluated using the Kellner and Sheffield Symptom Rating Test. The mean values thus obtained were adjusted using covariance analysis, with age and sex as the covariants. The 'new' hypertensives scored significantly lower for total neuroticism, depression and inadequacy than the normotensives. They also differed from the 'old' hypertensives, scoring significantly lower for total neuroticism, anxiety, somatization and inadequacy. However, no differences were revealed between the 'old' hypertensives and the normotensives. The significance and implications of these psychological differences are discussed.

Adult↗