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Biomedical subjects

S Zaretsky

Publications and source records attributed to S Zaretsky.

4 recordsLinked to original sources
PubMed1996

Comparison of conditional quality of life terminology and visual analogue scale measurements.

Two common formats for grading quality of life parameters are descriptive choices (mild, moderate, severe) and visual analogue scales. However the quantitative relationship between descriptive terminology and visual analogue scale scores has not been determined. A content neutral questionnaire was administered to 213 evaluable subjects who were asked to place the descriptors 'mildly', 'moderately', and 'severely' (presented in random order) on 100mm visual analogue scales. Visual analogue scales were presented without and then with hashmarks at 25mm, 50mm, and 75mm. Median visual analogue scale values for the descriptive terms differed significantly without hashmarks ('mildly' = 24mm', moderately' = 43mm, 'severely' = 84mm; p < 0.001) and also with hashmarks ('mildly' = 31mm, 'moderately' = 49mm, 'severely' = 85mm; p < 0.001). Comparison of interquartile range values (25th-75th percentile) revealed a distinct meaning for 'severely' (68-93mm) but marked overlap between 'mildly' (10-45mm) and 'moderately' (22-53mm). Errors of order (order other than 'mildly' < 'moderately' < 'severely') were made by 91 subjects. The discrepancy 'moderately' < 'mildly' accounted for most of these errors (72 subjects). Median values for 'mildly', 'moderately', and 'severely' are distinct and approximately linear on a visual analogue scale for large populations. However there is significant confusion between the terms 'mildly' and 'moderately' for individual subjects. Visual analogue scales can reveal finer quantitative differences than descriptive terms but require a significant time commitment for instruction and administration. Descriptive terms on a word-graphic scale or descriptive terms with numerical values to reenforce order of severity (0 = absent, 1 = 'mildly', 2 = 'moderately', 3 = 'severely') may be reasonable alternatives.

Adolescent↗
PubMed1995

Paclitaxel 3-hour infusion given alone and combined with carboplatin: preliminary results of dose-escalation trials.

Paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) by 3-hour infusion was combined with carboplatin in a phase I/II study directed to patients with non-small cell lung cancer. Carboplatin was given at a fixed target area under the concentration-time curve of 6.0 by the Calvert formula, whereas paclitaxel was escalated in patient cohorts from 150 mg/m2 (dose level I) to 175, 200, 225, and 250 mg/m2. The 225 mg/m2 level was expanded for the phase II study since the highest level achieved (250 mg/m2) required modification because of nonhematologic toxicities (arthralgia and sensory neuropathy). Therapeutic effects were noted at all dose levels, with objective responses in 17 (two complete and 15 partial regressions) of 41 previously untreated patients. Toxicities were compared with a cohort of patients in a phase I trial of paclitaxel alone at identical dose levels. Carboplatin did not appear to add to the hematologic toxicities observed, and the paclitaxel/carboplatin combination could be dosed every 3 weeks.

Adult↗
PubMed1994

Analysis of physician attitudes concerning requests for autopsy.

To quantify the role of failure to request consent as a determinant of the autopsy rate, questionnaires asking whether an autopsy had been requested and the reasons for that decision were distributed to primary physicians after each death in a consecutive series of 75 patient deaths. Autopsies were requested in only 56% of cases. Common reasons to request an autopsy included unanswered medical questions (37%), medical education (22%), research protocol participation (16%), or routine policy (14%). When autopsies were not requested, the most common reason was the belief that there were no outstanding medical questions (64%). Follow-up interviews with 14 oncologists and hematologists revealed that 8 generally request autopsies (usually to contribute to medical education or to discover unexpected findings) and 6 generally do not (usually because no unexpected findings are anticipated). Attempts to increase the current low autopsy rate should address the question of when and why physicians are willing to request this procedure.

Attitude of Health Personnel↗