PubMed Health⌕ Search

Biomedical subjects

S Zeni

Publications and source records attributed to S Zeni.

5 recordsLinked to original sources
PubMed1991

Compensatory parathyroid hypertrophy after hemiparathyroidectomy in rats feeding a low calcium diet.

The functional and anatomic compensatory response of the parathyroid gland was examined in hemiparathyroidectomized (HPTx) rats whose parathyroid hormone (PTH) secretion was stimulated by a low calcium diet. These responses were compared with those observed in the thyroid gland of hemithyroidectomized (HTx) rats. Rats kept on a low calcium diet for 10 days were subjected to HPTx, HTx, or sham operations. Throughout the experiment (up to 28 days after surgery), serum calcium levels of HPTx rats were lower than the basal, with delta values (mg/dl, mean +/- SEM) of -0.66 +/- 0.17 and -0.84 +/- 0.17, (P less than 0.05) 3 and 28 days after surgery, respectively. Serum PTH decreased significantly from 7 to 21 days after HPTx, reaching normality at day 28 after surgery. In HTx rats, serum thyroxine (T4) levels diminished significantly 7 days after surgery, and attained normality thereafter. The mitotic index (number of metaphases/1,000 cells) in parathyroid glands of colchicine-treated HPTx rats increased significantly in comparison to sham-operated controls, when examined 2 or 40 days after surgery. The mitotic index of thyroid follicular cells was significantly higher than that of their respective controls, 2 but not 40 days after HTx. These results indicate that after HPTx, a delayed compensatory response is found when the animals are kept under a low calcium diet. Parathyroid response is both delayed and of a minor degree compared to that found in the thyroid gland after HTx.

Adaptation, Physiological↗
PubMed1989

[Interrelationship between vitamin D intake and absorption and retention of calcium during nutritional recovery].

We have previously reported that, in the first stages of nutritional recovery, the needs of undernourished infants, in terms of protein-calories percentage (P%) are higher than normal, producing an accelerated catch-up. Consequently, calcium (Ca) and phosphorus (P) balances increase proportionally to weight gain rate (WGR) in order to attain a normal body composition. As for the control of Ca metabolism by vitamin D, the question is whether vitamin D intake must also be increased during this accelerated catch-up growth period. In this report we have analysed retrospectively previous results in order to clarify the interrelationship between Ca absorption, Ca retention and vitamin D intake. A total of 29 undernourished infants, from 2 to 18 months of age, were fed Ad libitum with one of two proprietary milk formulas containing, per 100 g.: Ca, 0.50 and 1.17 g.; P, 0.37 and 0.50 g.; vitamin D, 350 and 400 UI (8.7 and 10 micrograms); proteins, 11.34 and 17.00 kcal/100 kcal of total diet, respectively. Recommended Dietary Allowances (RDA) of Ca and vitamin D, according to FAO/OMS and NRC, were calculated with reference to normal infants body weight and to 1000 kcal of recommended dietary energy intake. Ca intake was higher than the RDA and ranged between 60 and 413 mg/kg/day; intake of vitamin D increased proportionally to food intake; calcium absorption ranged between 40.0 and 92.0% (mean = 69.8 +/- 14.6) and CaB correlated with Ca intake (r = 0.97), being higher than normal.(ABSTRACT TRUNCATED AT 250 WORDS)

Calcium↗
PubMed1988

The effect of tiaprofenic acid on uric acid excretion in man.

The uricosuric effect of tiaprofenic acid was evaluated in a group of normouricaemic inpatients with various rheumatic disorders. Six patients aged 26 to 60 years were maintained on a standardised low-purine diet and, after a washout period of 72 hours, tiaprofenic acid was administered in 3 oral doses of 300 mg 12-hourly. A normal renal function, as assessed by serum creatinine and creatinine clearance determinations, was considered mandatory for entry into the study. The following parameters were evaluated before and after treatment: haematological values, blood urea nitrogen (BUN), serum and urinary creatine concentrations, serum uric acid concentration and the fractional excretion rate of uric acid. Our preliminary results showed a substantial increase of urinary uric acid excretion in the samples collected after treatment, especially in the first 4 hours.

Adult↗