S Zisman | PubMed Health

PubMed2006

Crohn's-like colitis, enterocolitis and perianal disease in Hermansky-Pudlak syndrome.

Hermansky-Pudlak syndrome (HPS) is a rare autosomal recessively inherited disorder consisting of the triad of oculocutaneous tyrosinase-positive albinism, prolonged bleeding time secondary to platelet storage pool defect and ceroid depositions within the reticuloendothelial system. Some patients also reportedly have gastrointestinal (GI) complications related to chronic granulomatous colitis, enterocolitis and extensive granulomatous perianal disease, the later previously unreported in the literature. These observations suggest that the GI complications of HPS are due to the development of classical Crohn's disease. The implications for disease pathogenesis and surgical management are discussed.

Adult↗

PubMed1996

Invincible Athletics program: aerobic exercise and performance without strain.

This study compared physiologic pattern during conventional aerobic exercise to those during Invincible Athletics--a program emphasizing balance and comfort during exercise to increase strength, endurance, and mind-body coordination gradually without the negative effects of the stress/recovery cycle. While heart rats were similar during both workouts, during Invincible Athletics: (1) perceived comfort tended to be higher and perceived exertion tended to be lower; (2) breath rates were significantly lower; (3) respiratory sinus arrhythmia and central-parietal alpha relative power were significantly higher; and (4) endurance was significantly longer. Respiratory sinus arrhythmia decreases with physiologic and mental stress. Heightened respiratory sinus arrhythmia and EEG alpha relative power along with subjective reports of greater comfort, less exertion, and observed increased endurance suggest that during Invincible Athletics athletes may be more easily adapting to the demands made upon them.

Adolescent↗