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Biomedical subjects

S Zizolfi

Publications and source records attributed to S Zizolfi.

12 recordsLinked to original sources

Hand Test scores of panic disordered outpatients sexually abused as children.

A history of childhood sexual abuse has been implicated in a variety of adult psychiatric disorders as more frequent in females than in males and in subjects with more prominent dissociative symptoms such as panic disorder. Previous research has varied greatly in terms of methods, measurement instruments, and reported findings. Recent studies, however, suggest that projective techniques may be useful in resolving some of these inconsistencies. The present study utilized the Hand Test to investigate the late effects of childhood sexual trauma in a group of authenticated cases of panic disordered adult outpatients sexually abused as children compared to a matched sample of presumably nonabused patients. No statistically significant differences on quantitative variables were obtained between the two groups, but the group of outpatients (n = 16) sexually abused as children showed a larger latency to the ninth card of the Hand Test (shock reaction). This may be a potentially useful index in investigating cases of suspected abuse and confirms Wagner's (1983) contention that Card IX has a psychosexual "pull" as documented also by Italian studies.

Adult↗

Therapeutic effects of fengabine, a new GABAergic agent, in depressed outpatients: a double-blind study versus clomipramine.

The results of a double-blind clinical trial of fengabine vs clomipramine in depressed outpatients are reported. Fengabine, a new GABAergic agent, seems to be as effective as the reference drug, with a faster onset of action and a more marked effect on cognitive disturbances and retardation. The new drug is free of any significant anticholinergic or cardiovascular effect, and it is not sedative.

Adult↗

[Relation between HLA and schizophrenia in German couples].

The authors, in studying some patients for schizophrenia, typed for HLA system themselves and their sibs. In 11/13 cases the sibs who differ for illness differ also for HLA; that fits with the hypothesis that HLA and schizophrenia genes lie on the same chromosome. But the case is more complex because one of 13 couples, two identical twins, differ for illness but not for HLA antigens.

Female↗

Blood levels of S-adenosylmethionine in unmedicated schizophrenic and depressive patients.

S-Adenosylmethionine blood levels have been estimated by a specific radioenzymatic method in 52 schizophrenics and 12 depressives, diagnosed and subtyped according to ICD-9 and compared with 38 normal controls. Previous reports of significantly lower levels of blood SAMe in acute schizophrenics in comparison with normal subjects could not be confirmed in this study. Indeed, acute schizophrenics showed higher mean SAMe blood levels as compared both with chronic and with normal controls. No significant difference has been found comparing both schizophrenics as a whole and depressives with normal controls. This investigation aims to bring a contribution to the recently started critical revision of transmethylation hypothesis of schizophrenia.

Adolescent↗

[Neurotic and depressive status related to organic pathology in patients in thermal therapy].

Females and males with no psychiatric history, 25-75 years old, attending thermal facilities in Boario Terme (N = 449) and in Sangemini Terme (N = 40) were administered, on the 2nd-3rd day of their admission, a questionnaire expressly conceive in order to declare conscious motivations for thermal treatments and, in addiction, the Middlesex Hospital Questionnaire (MHQ), the Zung Self Rating Scale for Depression (ZUNG-D) and the State and Trait Anxiety Inventory (STAI), in order to detect neurotic symptoms and/or anxious or depressive complaints in this kind of population. A re-test was performed after 10 days by 73 subjects, in order to verify the impact of thermal treatments on psychoneurotic profiles. Baseline data were compared with those from normal controls and psychiatric outpatients. All statistical comparisons (probands versus matched controls; test versus re-test) were analysed by means of two-tailed Student "t" test (lever of significance: p less than 0.05). In the light of the data so obtained, subjects attending thermal facilities show a typical MHQ psychoneurotic profile, more marked in females and in subjects with gastrointestinal referred somatic disease and partially responding to thermal treatments, which supports the hypothesis that a particular form of neurosis may play a significant role in motivating request of thermal therapies. The results are largely discussed.

Adult↗