Isolation of highly purified hepatocytes from adult pig liver in multivisceral organ procurement.
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Biomedical subjects
S de Andrés
Publications and source records attributed to S de Andrés.
Equality of the in vivo and in vitro oxygen-binding capacity of haemoglobin in patients with severe respiratory disease.
The in vivo and in vitro oxygen-binding capacity of haemoglobin was determined on 10 occasions in nine patients who required mechanical ventilation. The in vitro sample was tonometered with 97% oxygen for 10 min and then with air, while the in vivo sample was obtained after 20 min of lung ventilation with pure oxygen. Subsequent laboratory procedures were identical for both samples. The mean oxygen-binding capacity of haemoglobin in vitro and in vivo samples were almost equal (1.365 +2- 0.010 and 1,366 +/- 0.007 ml per g Hb). When the measured inactive fractions of haemoglobin (carboxy- and methaemoglobin) were taken into account, these values increased to 1.392 +/- 0.005 and 1.392 +/- 0.007 ml per g Hb respectively.
Aged↗
[Interactions between foodstuffs and statins].
The existence of interactions between different drugs or between drugs and the diet is becoming better and better known. Statins are medicines currently in widespread use for the treatment of hyperlipidaemias. Diet has a great influence on the prevention and/or treatment of these pathologies as the therapeutic strategy used comprises appropriate diet and, if this does not succeed, pharmacological therapy is begun in combination with dietary advice. For this reason it is necessary to be aware of the potential interactions between this kind of medication and foodstuffs in order to avoid alterations in the therapeutic benefits and even the onset of adverse side effects. All of the statins are absorbed orally, so the impact of food intake on administration is extremely important to achieve an appropriate therapeutic effect. Many of the interactions of statins lie in their metabolism through cytochrome P-450 (except for pravastatin), thus making them candidates for interaction with certain foodstuffs or compounds contained in them, such as in the case of grapefruit juice. This paper reviews the drug-nutrient interactions with special attention to the interactions specific to statins and the mechanism of these interactions is described so as to contribute to their avoidance and thus improve this form of treatment in individuals with hyperlipidaemia.
Absorption↗