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S de Haan

Publications and source records attributed to S de Haan.

4 recordsLinked to original sources

Rectification in mesoscopic systems with broken symmetry: quasiclassical ballistic versus classical transport.

In suitably designed mesoscopic semiconductor structures, the phenomenon of ballistic rectification can be observed. A currently discussed microscopic model relates the observations to the interplay between fully quantized and quasiclassical current paths. We present measurements that contribute substantially to the clarification of the fascinating topic. In particular, we observe the opposite sign of the output voltage as compared to the prediction. Demonstrating the basic principle upon which the rectification is based--the asymmetry of the voltage drop in a quasiclassical wire--and extending the model to the classical transport regime, we can well explain our experiments as being caused by the interplay of quasiclassical ballistic and classical transport. Tunable ballistic rectifiers generating very large output signals and operating at room temperature raise the hope for future applications.

Journal Article↗

Chemoprophylaxis of depressions. An attempt to compare lithium with 5-hydroxytryptophan.

There are indications that the group of vital ('endogenous') depressions encompasses a subgroup with central 5-HT deficiency and that this factor contributes to the development of the (or some) depressive symptoms instead of resulting from them. In a majority of patients the suspected 5-HT deficiency persists even when the depressive symptoms have disappeared and the medication has been discontinued. This led us to the hypothesis that the disturbed central 5-HT metabolism is not a direct causal, but a predisposing factor. If this is true, then abolition of the suspected 5-HT deficiency, for example with the aid of 5-HTP, can be expected to have a prophylactic effect. This hypothesis was investigated in this study and confirmed. 5-HTP reduces the relapse rate in recurrent vital depressions with a unipolar and those with a bipolar course. This effect would seem to be most pronounced in patients whose disorders of central 5-HT metabolism are persistent. Tentatively it was concluded that 5-HTP seems to be inferior to lithium in bipolar patients and at least equivalent to lithium in unipolar patients. This problem, however, is still under investigation. 5-HTP prophylaxis is the first aimed (i.e. pathological substrate-oriented) type of chemoprophylaxis known in psychiatry.

5-Hydroxytryptophan↗

Central serotonin metabolism and frequency of depression.

Central serotonin (5-hydroxytryptamine; 5-HT) metabolism can be disturbed in a subgroup of patients with vital (endogenous, primary) depression. Presumably these disturbances do not result from the depression and have a predisposing rather than a causative relationship to it. This latter statement is based on two observations. First, in a majority of patients, the 5-HT disturbances persist after depression has abated. Secondly, 5-hydroxytryptophan seems to have prophylactic value, in particular in patients with persistent abnormalities in central 5-HT metabolism. In this study we approached the hypothesis that 5-HT disturbances are a predisposing factor to the occurrence of depression from still another perspective. If this hypothesis is correct, then depressive patients with persistent 5-HT disturbances should have higher frequencies of depression than depressive patients without demonstrable 5-HT disturbances. This was indeed demonstrated. The same was true for family members of probands with low levels of 5-hydroxyindoleacetic acid. No cerebrospinal fluid data are available for family members. The reported findings strongly support the predisposition hypothesis.

Adult↗